Ryan M. Glanz's research while affiliated with University of Iowa and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (7)
Primary motor cortex (M1) exhibits a protracted period of development that includes the establishment of a somatosensory map long before motor outflow emerges. In rats, the sensory representation is established by postnatal day (P) 8 when cortical activity is still "discontinuous." Here, we ask how the representation survives the sudden transition...
Primary motor cortex (M1) undergoes protracted development in mammals, functioning initially as a sensory structure. Throughout the first postnatal week in rats, M1 is strongly activated by self-generated forelimb movements-especially by the twitches that occur during active sleep. Here, we quantify the kinematic features of forelimb movements to r...
In humans and other mammals, the stillness of sleep is punctuated by bursts of rapid eye movements (REMs) and myoclonic twitches of the limbs.¹ Like the spontaneous activity that arises from the sensory periphery in other modalities (e.g., retinal waves),² sensory feedback arising from twitches is well suited to drive activity-dependent development...
Sleep, the predominant state of early infancy, is divided into two sub-states: active sleep (AS; or REM sleep) and quiet sleep (QS; or non-REM sleep). Behaviorally, AS is distinguished from QS by the presence of rapid eye movements (REMs) and abundant twitches across the body. Here, in the early postnatal period in human infants, we report the unex...
A bstract
Primary motor cortex (M1) undergoes protracted development in rodents, functioning initially as a sensory structure. As we reported previously in neonatal rats (Dooley and Blumberg, 2018), self-generated forelimb movements—especially the twitch movements that occur during active sleep—trigger sensory feedback (reafference) that strongly a...
Cortical development is an activity-dependent process [1, 2, 3]. Regarding the role of activity in the developing somatosensory cortex, one persistent debate concerns the importance of sensory feedback from self-generated movements. Specifically, recent studies claim that cortical activity is generated intrinsically, independent of movement [3, 4]....
S ummary
Cortical development is an activity-dependent process [1–3]. Regarding the role of activity in developing somatosensory cortex, one persistent debate concerns the importance of sensory feedback from self-generated movements. Specifically, recent studies claim that cortical activity is generated intrinsically, independent of movement [3, 4]...
Citations
... Another surprising aspect of M1 in early development is that its activity is modulated by behavioral state, in particular active sleep (AS, or REM sleep). In infant rats, this modulation reflects AS-dependent increases in neural activity that are enhanced by limb movements during AS, called twitches, that discretely and preferentially trigger sensory feedback to M1 (Dooley and Blumberg, 2018;Glanz et al., 2021). Importantly, AS-dependent modulation of activity is not unique to M1 but is seen in many developing sensorimotor structures (Blumberg, 2015;Blumberg et al., 2020). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281091625183-1666571072331_Q64/James-Dooley-9.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/619709015801859-1524761551894_Q64/Greta-Sokoloff.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/277024099848195-1443059100206_Q64/Mark-Blumberg.jpg)
... Interestingly, this process might involve brief muscle contractions -socalled myoclonic twitching. A recent study demonstrated that myoclonic twitches, which are thought to promote thalamocortical development through sensorimotor feedback loops, are concomitant with spindles in infants ( Sokoloff et al., 2021 ). This hypothesis is further supported by the findings outlined in our analysis of the same dataset demonstrating that an infant's spindle density correlates with nighttime movement ( Schoch et al., 2021 ). ...
... Although urethane precludes natural sleep-wake cycles, it does not prevent expression of spindle bursts in mPFC (Brockmann et al., 2011). Spindle bursts are brief thalamocortical oscillations that, in primary sensory areas, are closely associated with the processing of sensory stimuli (Khazipov et al., 2004;Hanganu et al., 2007;Dooley et al., 2020). In the mPFC of urethanized pups, however, spindle bursts appear to occur spontaneously. ...
