Ruolin Wang’s research while affiliated with Xi'an Jiaotong University and other places

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Publications (3)


Action potential-independent spontaneous microdomain Ca2+ transients-mediated continuous neurotransmission regulates hyperalgesia
  • Article
  • Full-text available

January 2025

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9 Reads

Proceedings of the National Academy of Sciences

Zhuoyu Zhang

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Jingyu Yao

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Jingxiao Huo

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[...]

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Rong Huang

Neurotransmitters and neuromodulators can be released via either action potential (AP)–evoked transient or AP-independent continuous neurotransmission. The elevated AP-evoked neurotransmission in the primary sensory neurons plays crucial roles in hyperalgesia. However, whether and how the AP-independent continuous neurotransmission contributes to hyperalgesia remains largely unknown. Here, we show that primary sensory dorsal root ganglion (DRG) neurons exhibit frequent spontaneous microdomain Ca ²⁺ (smCa) activities independent of APs across the cell bodies and axons, which are mediated by the spontaneous opening of TRPA1 channels and trigger continuous neurotransmission via the cyclic adenosine monophosphate-protein kinase A signaling pathway. More importantly, the frequency of smCa activity and its triggered continuous neurotransmission in DRG neurons increased dramatically in mice experiencing inflammatory pain, inhibition of which alleviates hyperalgesia. Collectively, this work revealed the AP-independent continuous neurotransmission triggered by smCa activities in DRG neurons, which may serve as a unique mechanism underlying the nociceptive sensitization in hyperalgesia and offer a potential target for the treatment of chronic pain.

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Sexually dimorphic dopaminergic circuits determine sex preference

January 2025

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130 Reads

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2 Citations

Science

Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex preference remain unclear. In this study, we show that both male and female mice exhibit female preference but shift to male preference when facing survival threats; their preference is mediated by the dimorphic changes in the excitability of ventral tegmental area dopaminergic (VTA DA ) neurons. In males, VTA DA projections to the nucleus accumbens (NAc) mediate female preference, and those to the medial preoptic area mediate male preference. In females, firing-pattern (phasic-like versus tonic-like) alteration of the VTA DA -NAc projection determines sociosexual preferences. These findings define VTA DA neurons as a key node for social decision-making and reveal the sexually dimorphic DA circuit mechanisms underlying sociosexual preference.


Citations (1)


... Amperometric CFE recordings in dorsal striatal slices were conducted as previously described [28,35,40]. Parkin KO, parkin KD and Syt11 OE mice were anesthetized with avertin (i.p.) and perfused with approximately 50 mL of ice-cold artificial cerebrospinal fluid (sectioning aCSF) containing (in mM): 110 C 5 H 14 NClO, 2.5 KCl, 0.5 CaCl 2 , 7.0 MgCl 2 , 1.3 NaH 2 PO 4 , 25 NaCO 3 , 10 glucose, saturated with 95% O 2 and 5% CO 2 . ...

Reference:

Compensatory synaptotagmin-11 expression conceals parkinson’s disease-like phenotypes in parkin knockout mice
Sexually dimorphic dopaminergic circuits determine sex preference

Science