Rui Hai Liu's research while affiliated with Cornell University and other places

Publications (205)

Article
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The phenolic profiles, antioxidant activity, antiproliferative property and the underlying molecular mechanisms of cell apoptosis of Rhodiola rosea free phenolic (RFE) were analyzed in this work. Overall, Rhodiola rosea rhizome phenolic extract (RE) contained Rhodiola rosea rhizome free phenolic extract (RFE) and Rhodiola rosea rhizome bound phenol...
Article
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The consumption of pistachios has been linked to many potential health benefits. Phytochemicals in pistachios, including phenolics, vitamin E and carotenoids, have been considered to make contributions to the health benefits. The objectives of this study were (1) to explore the phytochemical profiles (total phenolics and total flavonoids, including...
Article
Mitochondrial function is closely related to the body's oxidative stress level and lifespan. Our previous research demonstrated that the combination of blueberry extracts (BE) and apple peel extracts (APE) could synergistically promote the oxidative stress and lifespan of Caenorhabditis elegans (C. elegans). The purpose of this study was to determi...
Article
Background: Ferulic acid (FA) is a dietary polyphenol widely found in plant tissues. It has long been considered to have health-promoting qualities. However, the biological properties of dietary polyphenols depend largely on their absorption during digestion, and the effects of their intestinal metabolites on human health have attracted the intere...
Article
The changes in polyphenol fractions after in vitro fermentation of apple peel polyphenol (APP) by gut microbiota as well as the effects of APP on the growth, pH value, short‐chain fatty acids (SCFAs) production and intestinal flora composition of gut microbiota fermentation were firstly explored in the present study. The relative abundance of Lacto...
Article
There is fast increasing interest in the development of alimentary protein stabilized emulsions due to their potential applications in functional food fields. This work studied the effect of glycation degree with chitosan oligosaccharide (COS) on the emulsifying properties of lactoferrin (LF) through Maillard reaction. In the present study, SDS-PAG...
Article
Whole grains refer to grains or foods that contain all the bran, germ, and endosperm of the entire grain seeds with the original proportions. According to the Dietary Guidelines for Americans 2020–2025, whole grains are recommended to constitute at least half of the total grain intake. Highland barley (HB), as a principal crop widely cultivated in...
Article
Chickpea (Cicer arietinum L.), an annual plant of the Fabaceae family, is mainly grown in temperate and semiarid regions. Its biological activity and beneficial contribution to human health have been scientifically confirmed as an essential source of nutritional components. The objective of this review was to summarize and update latest available s...
Article
Here, we examined the phytochemical profiles, antioxidant activity (AA), and antiproliferative activity (APA) of four Chinese bayberry (Myrica rubra Sieb. et Zucc.) pulp extracts. They were found to be rich in total phenolics content (TPC; 186.45 ± 5.42 to 498.94 ± 8.25 mg of gallic acid equiv./100 g FW) and total flavonoids content (TFC; 126.28 ±...
Article
Background Free fractions of different blackberry varieties extracts are high in phenolic compounds with antioxidant activities. However, the phenolic profiles and antioxidant activities against peroxyl radicals of bound fractions of different blackberry varieties extracts have not been previously reported. In addition, what are the key antioxidant...
Article
In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process. We prepared a GO-COS complex to adsorb An and protect them from the destructive effects of their ambient environment....
Article
Thermal processing (TP) and high hydrostatic pressure (HHP) are two important puree processing methods. In this study, the polyphenol oxidase (PPO) and β-glucosidase activities, chromatic values, peroxide radical scav-enging capacities (PSCs), cellular antioxidant activities (CAAs), and anthocyanin profiles were evaluated in blueberry puree followi...
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Methionine restriction (MR) extends lifespan and delays the onset of aging-associated pathologies. However, the effect of MR on age-related cognitive decline remains unclear. Here, we find that a 3-month MR ameliorates working memory, short-term memory, and spatial memory in 15-month-old and 18-month-old mice by preserving synaptic ultrastructure,...
Article
Phenolic profiles and gene expression pattern in their synthetic pathway, total antioxidant activities and antiproliferative activities in two genotypes of sweet corn (YT16 and YT28) during kernel maturation were analysed. Results showed that increasing trends of phenolics and flavonoids in the two genotypes of kernels from 10 to 30 days after poll...
Article
The effects of whole grain highland barley (WGH) with rich phenolics on glucose metabolism, the insulin pathway, and microRNA (miRNA) expression in db/db mice were explored in the present study. Supplementation with WGH decreased the levels of blood glucose, glycosylated serum protein (GSP), insulin, and inflammatory cytokines in db/db mice. Furthe...
Article
Portulaca oleracea L. (PO), with abundant natural bioactive phytochemicals, exhibits potential bioactivities and pharmacological activities. However, the mechanisms of action of PO on anti‐aging effect remain unclear. In this study, the ethyl acetate fractional extract from PO (PO‐EA) was obtained by fractionation of solvent extractions, and its ef...
Article
The mechanisms of highland barley whole grain (BWG) with rich phenolics on obese db/db mice were investigated in this study. Oral consumption of BWG reduced food intake, body weight, organ/body weight indexes of liver and fat, levels of serum and hepatic lipids, liver injury, and oxidative stress. Furthermore, BWG recovered the disorder of cecal mi...
Preprint
Maternal obesity has been reported to be related to the neurodevelopmental disorders in offspring. The current study aims to examine the roles of diet on the gut microbiota and validating the microbiota-metabolites-brain axis as a major mechanism associated with cognitive and social behavioral changes in the offspring of maternal obesity. Here, a c...
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Raspberries are rich in phytochemicals with health benefits. Our previous research has shown raspberry extracts (RE) can promote longevity in Caenorhabditis elegans. The objective of this study was to determine whether the extension of lifespan was regulated by oxidative stress, and to explore the underlying mechanisms of action. The results showed...
Article
In this study, the content changes of anthocyanins levels, antioxidant activities as well as related genes in their biosynthesis pathways of two seasons black sweet corn kernels were determined. Generally, three anthocyanins contents showed similar trend with peak at 10 days after pollination (DAP) in both seasons existing as free forms, and they g...
Article
The potential mechanisms of action of ursolic acid (UA) in regulating cell proliferation in MDA-MB-231 human breast cancer cells through Nrf2 pathway were investigated. UA significantly inhibited the proliferation of MDA-MB-231 cells at a dose ≥10 μM in a dose-dependent manner, and no cytotoxicity was observed at concentrations below 29.87 ± 2.60 μ...
Article
BACKGROUND Black sweet corn as an eatable fruit has various nutrition. This study discussed the changes of four vitamins (vitamin C&E, folate and carotenoids) during black sweet corn maturation and further investigated the effect of preharvest weather conditions and related genes in multi‐vitamins biosynthesis pathways. RESULTS Most vitamins level...
Article
Phenolics, antioxidant activities, and antiproliferative properties of brown Hypsizygus marmoreus (brown HM) and white Hypsizygus marmoreus (white HM) were compared. The results showed that the contents of (+)‐catechin, gallic acid, and protocatechuic acid of brown HM were higher than those of white HM. Moreover, brown HM had greater cellular antio...
Article
Phenolic profiles, antioxidant, antiproliferative, and hypoglycemic activities of the whole Ehretia macrophylla Wall. (EMW) fruit were investigated in the present study. Catechin (CE), o ‐methoxy benzoic acid (o ‐MBA), and rosmarinic acid (RA) were the predominant phenolics in free extract, while CE, vanillic acid (VA), and o ‐MBA were for bound ex...
Article
Flaxseed is a rich source of lignans and hydroxycinnamic acids. In this study, the variation of lignans, hydroxycinnamic acids, and the transcription levels of genes involving lignan biosynthetic pathway of flaxseed capsules at different mature stages was investigated. Secoisolarisiresinol diglucoside showed a sharp increase during the early rapid...
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During mung bean post-germination seedling growth, various metabolic and physiological changes occurred, leading to the improvement of its nutritional values. Here, transcriptomic and metabolomic analyses of mung bean samples from 6-hour, 3-day and 6-day after imbibition (6-HAI, 3-DAI, and 6-DAI) were performed to characterize the regulatory mechan...
Article
The functional properties and physiological functions of whey protein isolate (WPI) decreased near its isoelectric point (PI). The Maillard reaction covalently binding polysaccharides to proteins is an effective method to improve the functional activities of proteins. WPI-inulin conjugates were prepared by wet-heating method at 70 °C for 2 h, 4 h a...
Article
The phytochemical contents, peroxyl radical scavenging capacities (PSCs) and cellular antioxidant activities (CAAs) of free and bound fractions of rice were reported. Black rice had the highest total phenolic content and total flavonoid content in free and bound fractions, followed by red rice, brown rice, and polished rice. Black rice contained mu...
Article
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Orange, with various bioactive phytochemicals, exerts various beneficial health effects, including anti-cancer, antioxidant, and anti-inflammatory properties. However, its anti-aging effects remain unclear. In this study, the Caenorhabditis elegans (C. elegans) model was used to evaluate the effects of orange extracts on lifespan and stress resista...
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Nobiletin (NOB), one of polymethoxyflavone existing in citrus fruits, has been reported to exhibit a multitude of biological properties, including anti-inflammation, anti-oxidation, anti-atherosclerosis, neuroprotection, and anti-tumor activity. However, little is known about the anti-aging effect of NOB. The objective of this study was to determin...
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The present study was designed to analyze and compare phytochemical activities of four different cultivars of kiwifruit. Among all investigated varieties, Hua You (HY) and Cui Xiang (CUX) displayed the maximum concentration of phytochemical content, and the highest total phenolic results were observed in HY and CUX cultivars with 220.20 ± 1.12 mg G...
Article
The therapeutic benefits of whole grain on diabetes mellitus have been continuously confirmed by in-depth research. To date, limited studies have investigated the effect of extruded products of whole grain on the insulin signaling pathway in vivo. This study investigated the effects of oral consumption of whole grain extrudate, including 97% brown r...
Presentation
Previous in vitro digestion treatments were conducted directly to whole grains without extraction of free phenolics, thus the bioaccessible phenolics contained both free phenolics that survived the digestion and digested phenolics released by digestion. The present study aimed to investigate the phytochemical contents, peroxyl radical scavenging ca...
Article
Most of the previous in vitro digestion treatments were conducted directly to whole grains without extraction of free phenolics, thus the bioaccessible phenolics contained both free phenolics that survived the digestion and digested phenolics released by digestion. However, the profiles of digested phenolics released by digestion remain unknown. Th...
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Ramie (Boehmeria nivea L.) is usually cultivated as a fiber crop, but it is also well known for its potential use in animal feeding with viable commercial applications. In this study, the phenolics profile as well as cellular antioxidant and antiproliferative activities were investigated in free and bound fractions of six different vegetative parts...
Article
A novel polysaccharide (MFP4P) was isolated from mulberry fruits (Morus alba L.) pulp using a combination of DEAE-Sepharose fast-flow and Sephadex G-100 chromatographic columns. Structural characterization revealed that MFP4P was composed of arabinose, rhamnose, galactose, glucose and galacturonic acid with a molecular weight of 198.2 kDa. The link...
Article
Ultraviolet radiation induces skin damage, inflammation, and aging. To explore the protective effects of blueberry extract (BE) against ultraviolet-C (UV-C) radiation, we analysed human skin keratinocyte (HaCaT) and human foreskin fibroblast (HFF) cells alone or in a co-culture, treated or not with BE, after exposure to UV-C. Surprisingly, MMP-1 wa...
Article
This study aims to evaluate phenolics, flavonoids, total and cellular antioxidant activity (CAA), antioxidant capacity in ear sections of sweet corn. Corn cob and mature corn silk showed the highest contents of total phenolics and flavonoids (p < 0.05), respectively. Gallic acid and ferulic acid were the main free and bound phenolics in each ear pa...
Article
In the present study, the digestion properties of a polysaccharide from Rosa roxburghii fruit (RTFP-3) under saliva, simulated gastric and small intestinal conditions were studied for the first time. The results indicated that human saliva had no effect on RTFP-3. RTFP-3 was slightly degraded in simulated gastric and small intestinal juices. The mo...
Article
Blueberry is rich in bioactive phytochemicals with a wide of range of biological activities and health benefits. However, little is known about their effects on aging. The objectives of this study were to evaluate the effects of supplementation with a blueberry extract (BE) on lifespan and stress resistance using Caenorhabditis elegans (C. elegans)...
Article
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Whole grain has a wide range of phytochemicals exhibiting health benefits of lowering risk of chronic diseases. As commonly consumed grain product, corn has unique profiles of nutrients and phytochemicals when compared with other whole grains. Corn nutrients and phytochemicals include vitamins (A, B, E, and K), minerals (Mg, P, and K), phenolic aci...
Presentation
The phytochemical contents, peroxyl radical scavenging capacities (PSCs) and cellular antioxidant activities (CAAs) of free and bound fractions of rice with different colors were reported. Black rice had the highest total phenolic content and total flavonoid content in free and bound fractions, followed by red rice, brown rice, and polished rice, e...
Article
The peel of the red-jambo concentrates the majority of the bioactive compounds and antioxidant capacity of the fruit. Minor phenolic compounds in this part of the fruit are still unknown, as well as the effect of its extracts in in vitro and in vivo studies. In an ethanolic extract of red-jambo, a wider range of phenolic compounds was investigated...
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Rice husks (RHs) as an agro-waste generated from rice production, while its application is limited. This study was designed to introduce a full utilization of rice husks, which extracted the phytochemical at first and then produced cellulose nanocrystals (CNCs) as the use of the residue. Furthermore, the phytochemicals extracted from rice husk was...
Article
Consumption of brown rice is associated with reduced risk of chronic diseases, which might be attributed to the presence of unique phytochemicals. This study aimed to evaluate phytochemicals profile, cellular antioxidant and anti-proliferative activities in glutinous and non-glutinous brown rice varieties of indica and japonica subspecies. In gener...
Article
Cancer is a severe health problem that significantly undermines life span and quality. Dietary approach helps provide preventive, non-toxic and economical strategies against cancer. Increased intake of fruits, vegetables and whole grains are linked to reduced risk of cancer and other chronic diseases. The anti-cancer activities of plant-based foods...
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Sweet corn kernels were used in this research to study the dynamics of vitamin E, by evaluatingthe expression levels of genes involved in vitamin E synthesis, the accumulation of vitamin E, and the antioxidant activity during the different stage of kernel development. Results showed that expression levels of ZmHPT and ZmTC genes increased, whereas...
Article
In this work, recovery of phenolics from sugarcane bagasse was performed and total phenolic content, total flavonoid content and antioxidant activities were measured. Four fractions were yielded after extraction with various solvents and ethyl acetate fraction was performed into further purification, producing 30 sub-fractions (G1–G30). Six compoun...
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To have a better understanding of regulatory mechanism of carotenoid accumulation in sweetcorn (Zea mays L.), we analysed carotenoid profiles, expression patterns of carotenogenic genes and antioxidant activities in two genotypes of sweetcorn during kernel development. The results suggested that the expression of carotenogenic genes played an essen...
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Practical application: The lipid-based nanotechnology, namely self-microemulsion drug delivery system (SMEDDS) was used to improve the bioavailability and oral delivery of total flavones of Hippophaë rhamnoides L. (TFH). The relevant bioavailability of TFH could be remarkably 3-fold improved by the optimized SMEDDS. The SMEDDS produced via a simpl...
Article
The objective of the present study is to investigate the hepatic steatosis relieving effect of Averrhoa carambola free phenolic extract(ACF)on leptin receptor-deficient (db/db) mice, and elucidate the modulation hepatic lipogenesis mechanisms. Serum Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) assay, accompanied hematoxylin a...
Article
Phenolics, antioxidant and antiproliferative properties of Sea buckthorn berries were evaluated using a simulated in vitro digestion and compared with chemical extraction method. Digested samples were subjected to antiproliferation evaluation against human liver, breast and colon cancer cells. Furthermore, the bioaccessibility of digested berries w...
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Colorectal cancer (CRC) is one of the leading causes of cancer deaths around the globe. Bioactive food ingredients such as prebiotics have protective potential in colon cancer. Data on galacto-oligosaccharides (GalOS) against CRC are very limited and GalOS used in this study have β-1,6 and β-1,3 as major glycosidic linkages and, to our best knowled...
Article
Microwave-assisted extraction of Moringa oleifera Lam. leaf polysaccharides was investigated using a response surface methodology. The following conditions were found to generate an experimental yield of 2.96 ± 0.11%, which closely agreed with the predicted value of 2.89%: time 70 min, microwave power 700 W, temperature 70 °C and a liquid/solid rat...
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The aim of this study was to evaluate the anti-inflammation effects of blueberry extracts through NLRP3 inflammasome. The anti-inflammation activities of blueberry extracts were detected using lipopolysaccharide (LPS) activated the mononuclear macrophage (RAW264.7), and then detected the gene expression levels of NLRP3, Caspase-1, apoptosis-associa...
Article
The phytochemical profiles and antioxidant activity of free, soluble-conjugated, and bound fractions of brown rice and its processed products (textured rice, cooked rice and rice noodle) were studied. Nineteen phenolic acids were identified. Trans-ferulic acid was the most abundant monomeric phenolic acid with trans-trans-8-O-4′ diferulic acid bein...
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Little work has been conducted on the evaluation of antioxidant and antiproliferative activities of different sesame seed varieties. This article compared the total phenolics, antioxidant contents, and the antiproliferative activities of six varieties of white sesame seeds. Total contents of phenolics and flavonoids ranged between 370.5–786.8 mg GA...