Ruchika Bajaj's research while affiliated with UCSF University of California, San Francisco and other places
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Publications (7)
MRP4 is unique among the C family of ATP-binding cassette transporters for its role in translocating prostanoids, an important group of signaling molecules derived from unsaturated fatty acids. Using a reconstituted system, we report that a pair of prostaglandins (PGs) and the sulfonated-sterol DHEA-S preferentially enhance the ATPase activity of M...
ABC transporters are molecular machines which power the solute transport using ATP hydrolysis. The structural biology of ABC transporters has been exploding for the last few years, and this study explores timelines and trends for various attributes such as structural tools, resolution, fold, sources, and group leaders. This study also evidences the...
P-glycoprotein (P-gp) plays a critical role in drug oral bioavailability, and modulation of this transporter can alter the safety and/or efficacy profile of substrate drugs. Individual oral molecular excipients that inhibit P-gp function have been considered a mechanism for improving drug absorption, but a systematic evaluation of the interaction o...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has emerged as a major global health threat. The COVID-19 pandemic has resulted in over 168 million cases and 3.4 million deaths to date, while the number of cases continues to rise. With limited therapeutic options, the identif...
Biological membranes define the boundaries of cells and compartmentalize the chemical and physical processes required for life. Many biological processes are carried out by proteins embedded in or associated with such membranes. Determination of membrane protein (MP) structures at atomic or near-atomic resolution plays a vital role in elucidating t...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has emerged as a major global health threat. The COVID-19 pandemic has resulted in over 80 million cases and 1.7 million deaths to date while the number of cases continues to rise. With limited therapeutic options, the identific...
Citations
... We note that during the preparation of our manuscript, several hMRP4 structures were reported in the substrate-bound and inhibitor-bound states [38][39][40] . Interestingly, in these studies, the ATP-bound structures were in the outward-occluded conformations 39,40 , different from the outward-open conformation in our ATP-bound hMRP4 and the reported ATP-bound bMRP1 structures solved in detergent 22 . ...
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... × 10 −6 cm/s for stimulated cells ( Figure 4D). In a separate model, we investigated whether direct stimulation of VK2/E6E7 cells with pro-inflammatory cytokines (TNF-α, IL-1β or IL-6) altered the permeability of digoxin, an extensively characterised substrate of the P-gp efflux transporter [31]. ...
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... Site-specific P-gp inhibition along the intestine, as observed by verapamil in the literature, may impact overall drug absorption (56). Many surfactants and one polymer have also been shown in vitro to inhibit P-gp in MDCK-MDR1 cells while five dyes and one suspending agent showed minimal inhibition in HEK293 cells (41,57). ...
... In this analysis, we selected and compared 15 drug repurposing screening efforts for COVID-19 using susceptible mammalian cells and full-length SARS-CoV-2. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] We limited this analysis to screens that used full-length SARS-CoV-2 to include repurposed drugs that have either a direct or indirect effect on viral replication. Each of these studies confirmed the relevance of their hits. ...
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... The optimised conformations of CBG and its analogues with the lowest free-energies (CBG, CBD and olivetol) were the fully extended straight-chain geometries. These were each docked onto human cytochrome P450-3A4 (PDB: 1W0E) 53 in the GOLD 2022 1.0 molecular docking suite. 54 Furthermore, differing conformations of the CBG system were docked and scored relative to the fully-extended geometry to resolve the influence of conformation on bioactivity. ...
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