Roxana N. Beladi's research while affiliated with Arizona State University and other places
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Publications (8)
Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate serine proteases in the central coagulation and immune pathways, representing 2–10% of circulating proteins in the blood. Serine proteases form cascades of sequentially activated enzymes that direct thrombosis (clot formation) and thrombolysis (clot dissolu...
Background
Viral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown.
Objective
An unbiased, blinded screening for RNA viruses was performed after chemotherapy with correlation to cardiac function.
Methods
Hi...
Introduction: Chemotherapy for hematologic malignancies can cause severe cardiomyopathy. Chemotherapeutic agents also induce immune suppression increasing the risk of opportunistic infections.
Hypothesis: We have hypothesized that immunosuppression after chemotherapy increases opportunistic viral infections, myocarditis and cardiomyopathy.
Methods:...
In this article, we report a case of a 61-year-old male who was diagnosed with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), presenting with acute respiratory distress syndrome requiring intubation and hemodynamic support, marked D-Dimer and troponin I elevation, worsening ST-elevation myocardial infarction on repeat electrocardiogr...
Right atrial (RA) masses are rare, challenging to diagnose, and potentially life-threatening with high mortality if untreated. We present a patient presenting with diffuse large B-cell lymphoma in the brain that was incidentally found to have a large RA mass. For a better definition of the RA mass, extensive workup using multimodality imaging inclu...
Progressive neurological damage after brain or spinal cord trauma causes loss of motor function and treatment is very limited. Clotting and hemorrhage occur early after spinal cord (SCI) and traumatic brain injury (TBI), inducing aggressive immune cell activation and progressive neuronal damage. Thrombotic and thrombolytic proteases have direct eff...
Objective: We review prior studies on the incidence of hypertension (HTN) after earthquakes and present a retrospective analysis of HTN after the 2010 earthquake in Haiti.
Methods: Prior reports on HTN incidence were reviewed and a retrospective chart review for diagnosis of HTN in 4,308 patient charts was performed over a 7 year period (five clini...
Most preoperatively discovered complete heart block cases without cardiac clearance in a non-emergent situation are managed with deferral of elective surgery until a cardiology workup can be completed. The medical consequences of surgical delays can manifest in increased costs to the healthcare system via the treatment of more advanced disease, oft...
Citations
... It has a high mortality rate and is a considerable socioeconomic concern (2). AMI is mainly caused by coronary artery occlusion and the interruption of blood flow, leading to ischemic necrosis and irreversible cardiomyocyte loss through oxidative stress, inflammatory responses and morphological changes in myocardial fibroblasts (3)(4)(5). Cardiomyocyte loss comprises the necrosis or apoptosis of cardiomyocytes. The loss of cardiomyocyte excitation and contractility leads to functional disorders of cardiomyocyte function. ...
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... Based on the amino acid sequence inserted between the first two CC amino acids in the sequence, there are four categories of chemokines: C, CC, CXC, and CX3C. CC chemokines are associated with the activation and migration of monocytes and lymphocytes, whereas CXC chemokines are often linked to the activation and migration of neutrophils and macrophages [73]. After SCI, the CC chemokine subtype CCL2 is protective by recruiting macrophages to the site of the injury and promoting the conversion of macrophages into an anti-inflammatory, neuroprotective M2 phenotype. ...
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... However, the World Health Organization (WHO) announced that more than 23 million people may be affected [2,3]. This horrifying figure could be attributed to the earthquake's effects, which caused survivors physical and psychological stress [4]. Beta-blocker medications can be given to the survivors after a disaster to reduce such stress [5]. ...
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