Roberta Dalle Molle’s research while affiliated with McGill University and other places

... 46 A recent study found that decreased handgrip strength did not predict malnutrition and clinical outcomes. 47 However, the study used reference handgrip strength values from another country with a similar ethnic population, and the lack of a recommended cut-off for reduced handgrip strength limits the comparability of the study results. In contrast, Mckirdy et al. 34 handgrip strength was predictive of body composition and the need for dietetic intervention in sick children. ...

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Paediatric handgrip reference curves and the relationship between lower handgrip strength and clinical outcomes of hospitalised children

... Interestingly, these associations are moderated by a polygenic score informed by the striatal dopamine transporter gene co-expression network. Parallel independent component analyses comparing adults born low birth weight and controls revealed a neuroanatomo-functional association between gray matter content in the OFC, cingulate and temporal cortex and genes related to regulation of dendrite growth and neuron modelling (Barth et al., 2024), suggesting that prenatal adversity may act through these processes (Batra et al., 2023) to influence OFC structure with consequences in emotional and physical health (Barth et al., 2024). ...

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Early environmental influences on the orbito-frontal cortex function and its effects on behavior

... However, there is currently no globally standardized pediatric nutritional risk assessment tool. Most pediatric nutrition tools developed internationally, such as STRONGkids, Pediatric Yorkhill Malnutrition Score, and Pediatric Malnutrition Assessment Screening Tools, primarily serve as malnutrition risk screening tools [13,14]. They are based on the principles of nutritional screening tools outlined by the European Society for Parenteral and Enteral Nutrition (ESPEN) and can be temporarily employed as proxies for "nutritional risk" tools in clinical settings. ...

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Comparison of two nutritional risk screening tools in hospitalized children with Japanese encephalitis: a causal inference of clinical outcomes and implications for optimized management

... The frontal, prefrontal and orbitofrontal cortices were related to the significant subset of SNPs identified by the pICA analysis (see Supplementary information Supplementary Discussion for complement discussion of the associated processes related to the subset of SNPs identified by the pICA analysis). This is aligned with evidence demonstrating that resting state functional connectivity between the orbitofrontal cortex and dorsolateral prefrontal cortex is altered in human individuals born small for gestational age, at different ages during development 90 . ...

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Striatal dopamine gene network moderates the effect of early adversity on the risk for adult psychiatric and cardiometabolic comorbidity

... Previous studies demonstrated this approach to be effective for producing robust long-term impairments in cognitive-motor functions, brain development, neuronal and glial protein/gene expression, and insulin/IGF-1 signaling [37,87,145], similar to the abnormalities observed with chronic prenatal exposures via the pregnant dam's diet [42,45,146]. Although intragastric administration enables binge alcohol exposures [147][148][149][150], the alternative intraperitoneal injection approach is recognized by the alcohol research field [151] and has been successfully utilized by investigators over at least the past two decades [152][153][154][155]. Moreover, even maternal i.p. alcohol administration has been used to produce binge alcohol-mediated FASD [89,90]. ...

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Differential Early Mechanistic Frontal Lobe Responses to Choline Chloride and Soy Isoflavones in an Experimental Model of Fetal Alcohol Spectrum Disorder

... In a prospective cohort study composed of Brazilian adolescents, participants who were born small-for-gestational age had a higher snack caloric density and this eating behavior was associated with insulin sensitivity and changes in the hippocampus. Insulin modulates the central dopaminergic response, which is related to reward sensitivity [32]. Therefore, the change in insulin sensitivity in these neural pathways due to restriction can modify behavioral responses [11,17]. ...

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Intrauterine growth restriction and sugar consumption at two years of age in the BRISA cohort

... Dysfunctional CFTR leads to inflammation and infection of the airways, as well as a progressive decrease in lung function, which leads to respiratory failure and premature death (5)(6)(7). There are many determinants of pulmonary function in CF, including underlying genetic defects, existing bacterial pathogens, medication adherence, psychosocial factors, and nutritional status (8,9). The disease also affects various systems of the body, including the gastrointestinal tract, pancreas, sweat ducts, skeletal muscle, car-diovascular, and reproductive organs (6,10). ...

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The Association of Serum Elements’ Levels with the Severity of Pulmonary Involvement in Cystic Fibrosis Patients

... The lack of motivation to engage in health-promoting behaviors was described in studies but was not necessarily associated with depressive symptoms [33]. A study shows that individuals who live without identified psychological problems, such as depression or anxiety, may present a lack of motivation only linked to engaging in health-promoting behaviors and being motivated in other areas of life [28,34,35]. On the other hand, studies show that people with greater impulsivity have greater difficulty adhering to the diet and poor adherence to drug therapy [36,37]. ...

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Ineffective health maintenance behaviors in people with chronic conditions: Systematic review of etiology and risk

... This supports the hypothesis that stress stimuli can alter the eating pattern of rats, with stressed animals preferring comfort foods more than non-stressed animals. Some previous studies support these findings and suggest that stress conditions can lead to two profiles: the anxiogenic and the anorexigenic [9,26]. Although behavioral tests were not used in the present study, it was possible to observe that group S + CF had lower food consumption than group C + CF (both in grams and in kcal/kg of body mass). ...

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Effects of comfort food diet on the penile morphology of stressed rats

... Studies carried out on animal models and children have highlighted the mechanisms that may explain the relationship between IUGR and increased consumption of sweet foods [7][8][9][10][11][12]. Children and adults with IUGR have shown more impulsive behavior, poor inhibitory control and a modified hedonic response (taste reactivity) to palatable foods, i.e. those high in sugars and/or fats [9,[13][14][15]. ...

Reference:

Intrauterine growth restriction and sugar consumption at two years of age in the BRISA cohort