Robert Katz’s research while affiliated with Royal Free London NHS Foundation Trust and other places

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Publications (7)


Fig. 1 Coronal T1-weighted MR image of the femora. There is diffuse, heterogenous hypointensity throughout both femora and visualised tibiae in keeping with Gaucher infiltration 
Fig. 2 Coronal GRE (T2*) MRI of the hips demonstrating diffuse hypointensity throughout the diaphysis and metaphysis of both femora with relative sparing of the proximal epiphysis and apophyis 
Fig. 3 Sagittal STIR MR image of the right humerus demonstrating relatively homogeneous hyperintensity within the diaphysis and metaphysis with sparing of the epiphysis 
Fig. 4 
Fig. 5 Sagittal T1-weighted MR image of the lumbar spine. There is diffuse bone marrow infiltration and chronic infarction and vertebral body collapse of L3 and to a lesser extent L5 vertebral bodies

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Radiological aspects of Gaucher disease
  • Literature Review
  • Full-text available

December 2011

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2,876 Reads

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26 Citations

Skeletal Radiology

Robert Katz

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Advances in imaging and the development of commercially available enzyme therapy have significantly altered the traditional radiology of Gaucher disease. The cost of treatment and need for monitoring response to therapy have magnified the importance of imaging. There are no recent comprehensive reviews of the radiology of this relatively common lysosomal storage disease. This article describes the modern imaging, techniques and radiological manifestations of Gaucher disease.

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Imaging of Shoulder Prostheses: What the Orthopedic Surgeon Needs to Know

November 2009

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24 Reads

PURPOSE/AIM This educational exhibit aims to familiarise the reader with both the normal and abnormal appearance of the various surgical options that exist for prosthetic replacement of the shoulder joint. This includes total joint replacement, hemiarthroplasty, reverse geometry arthroplasty, resurfacing prostheses and fracture prostheses. CONTENT ORGANIZATION Review of the different shoulder prostheses and the clinical indications for each. Normal post-operative appearances. Post-operative complications including malpositioning, migration, loosening, infection, periprosthetic fracture, scapula notching and impingement. Examples are demonstrated with Plain Film, CT, MRI and Nuclear Medicine. The indications for the different imaging modalities are discussed. SUMMARY In recent years prosthetic replacement of the shoulder joint has become increasingly common and a number of new surgical techniques have been developed. It is important that the radiologist is familiar with these advances. This educational exhibit provides a comprehensive review of the various shoulder prostheses with demonstration of their normal appearances and the complications that should be looked for in post-operative imaging evaluation.


A National Center's Pictorial Review of Scleroderma

November 2009

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17 Reads

PURPOSE/AIM 1) Describe the imaging experiences of a National Scleroderma Treatment Center 2) Review the basic clinical and pathological findings 3) Outline the new and novel imaging techniques in the diagnosis and prognosis 4) Illustrate a comprehensive pictorial review CONTENT ORGANIZATION Scleroderma can affect a wide range of organs. Manifestations include joint disease, gastrointestinal dysmotility, pulmonary fibrosis, and soft tissue calcification. Various radiological techniques such as HRCT, Barium studies, plain films, and ultrasound are essential for diagnosis and assessment of disease extent. Recently, MRI has assumed a role in disease assessment. As a national center of scleroderma, we will present a pictorial review of our imaging algorithm and findings. SUMMARY -The organic manifestations of Scleroderma are described. -Basic clinical and pathologic findings will be reviewed. -Different imaging modalities used in the assessment and prognosis of scleroderma will be discussed. -The characteristic findings will be demonstrated via a pictorial review.


Imaging and Histopathologic Features of HIV-related Renal Disease1

September 2008

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1,247 Reads

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47 Citations

Radiographics

Despite extraordinary recent advances in the management of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome, patients infected with HIV are still susceptible to a variety of complications that stem either from immunodeficiency or from side effects of antiretroviral regimens. Diagnosis is often challenging, since every organ in the body can be affected by HIV, and the kidneys have been increasingly shown to be involved by a variety of disease processes. Opportunistic infections including those caused by atypical organisms, malignancies such as lymphoma and Kaposi sarcoma, and disease processes specific to HIV infection such as HIV-associated nephropathy have all been shown to affect the kidneys. In this era of highly active antiretroviral therapy (HAART), renal disease arising secondary to antiretroviral medication has been added to the list. Furthermore, the introduction of HAART has increased survival of HIV-infected patients; consequently, the frequency of HIV-associated and incidental renal disease is expected to rise in this population. Because mortality and morbidity rates are affected by the early recognition of renal disease in HIV-infected patients, it is paramount that the radiologist be familiar with the imaging features that can be encountered in such cases.



Musculoskeletal Manifestations of Chronic Renal Failure and Dialysis

68 Reads

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2 Citations

PURPOSE/AIM 1. To present a comprehensive multi-modality pictorial review of renal osteodystrophy and dialysis related musculoskeletal disorders. 2. To discuss the underlying biochemical disturbances and pathophysiology leading to these various manifestations. CONTENT ORGANIZATION *Background and disease frequency *Review of normal bone physiology *Radiology of renal osteodystrophy including osteomalacia/rickets, hyperparathyroidism, osteosclerosis, soft tissue and vascular calcification. *Radiology of dialysis related MSK disorders including crystal arthropathies, septic arthritis/osteomyelitis, amyloidosis, osteonecrosis, destructive spondyloarthropathy, dialysis cysts and tendonitis/tendon rupture.* For each disorder the clinical presentation and pathophysiology is also discussed. SUMMARY MSK abnormailities are frequent sequelae of chronic renal failure and dialysis with significant associated morbidity. It is important to be aware of the various clinical and imaging appearances to optimise patient management.


Imaging and Histopathological Features of HIV Related Nephropathy

PURPOSE/AIM 1. To illustrate the radiological features of HIV related renal disease including antiretroviral related nephropathies. 2. To describe and illustrate the histopathological features of HIV related renal disease. CONTENT ORGANIZATION 1. Pathophysiology of HIV related renal disease. 2. Imaging and associated histopathological features of HIV related renal disease (a) HIV associated immune mediated renal disease (b) HIV associated nephropathy (c) opportunistic infections affecting the renal tract seen in patients with HIV e.g renal PCP, MAI and renal cortical infections e.g candida (d) HIV associated renal lymphoma (e) antiretroviral associated nephropathy. 3. Sample cases. 4. Discussion SUMMARY The major teaching points of this exhibit are 1. Renal disease is a relatively common complication in patients with HIV. Here we give an overview of the various renal pathologies encountered in patients with HIV. 2. There are various radiological features that are encountered in each pathology as illustrated. 3. Renal disease is important to recognise in HIV patients as it is a major cause of morbidity and mortality in this group of patients.

Citations (3)


... Avascular necrosis, osteomyelitis ( Fig. 8a, b), septic arthritis, tendinosis/tendon rupture and bursitis/synovitis are caused by a combination of chronic renal failure, steroid/ immunosuppressants and dialysis [25]. Abnormalities involving the musculoskeletal system are numerous and frequent in patients with chronic renal insufficiency. ...

Reference:

Imaging of haemodialysis: renal and extrarenal findings
Musculoskeletal Manifestations of Chronic Renal Failure and Dialysis
  • Citing Conference Paper

... It is a familial lipodystrophic condition caused by a deficiency in the enzyme glucocerebrosidase (G Case), leading to intracellular accumulation of glycosphingolipids in monocytemacrophage systemic cells (Gaucher cells) inside the liver, spleen, and bone marrow. Hepatosplenomegaly and bone marrow infiltration with skeletal system affection are the most common presentations [1][2][3]. ...

Radiological aspects of Gaucher disease

Skeletal Radiology

... Human Immunodefi ciency Virus (HIV) infection and Acquired Immunodefi ciency Syndrome (AIDS) are a spectrum of conditions resulting from infection by the human immunodefi ciency virus [1][2][3][4][5]. HIV is a retrovirus that causes an immune disorder characterized by a decline of immune function and of Helper T-cells (notably CD4 T cells) [1,[5][6][7][8]. ...

Imaging and Histopathologic Features of HIV-related Renal Disease1

Radiographics