Robert Eder's research while affiliated with Harvard Medical School and other places
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Publications (19)
Background:
Myocardial infarction (MI) is a major risk factor for the development of heart failure with reduce ejection fraction (HFrEF). While previous studies have focused on HFrEF, the cardiovascular effects of ketone bodies in acute MI are unclear. We examined the effects of oral ketone supplementation as a potential treatment strategy in a sw...
Background:
Obesity is associated with derangement of cardiac metabolism and the development of subclinical cardiovascular disease. This prospective study examined the impact of bariatric surgery on cardiac function and metabolism.
Methods:
Subjects with obesity underwent cardiac magnetic resonance imaging (CMR) at Massachusetts General Hospital...
Background
Late gadolinium enhancement cardiac magnetic resonance imaging is an effective and reproducible method for characterizing myocardial infarction. However, gadolinium‐based contrast agents are contraindicated in patients with acute and chronic renal insufficiency. In addition, several recent studies have noted tissue deposition of free gad...
Molecular phenotyping by imaging of intact tissues has been used to reveal 3D molecular and structural coherence in tissue samples using tissue clearing techniques. However, clearing and imaging of cardiac tissue remains challenging for large-scale (>100 mm ³ ) specimens due to sample distortion. Thus, directly assessing tissue microstructural geom...
Introduction: Myocardial infarction (MI) is a major risk factor for the development of heart failure with reduce ejection fraction (HFrEF). While previous studies have focused on HFrEF, the role of ketone bodies in MI is unclear.
Hypothesis: K etone may exert some cardioprotective effects following MI.
Methods: Male Yorkshire pigs underwent percuta...
Background: Exercise promotes cardioprotective benefits for the adult heart; however, the exercise-induced molecular and microstructural remodeling processes have yet to be fully characterized. This study sought to define the spatial interactions between molecular and microstructural remodeling that are induced by exercise and might result in cardi...
Preclinical models of aortic stenosis can induce left ventricular pressure
overload and coarsely control the severity of aortic constriction. However,
they do not recapitulate the haemodynamics and flow patterns associated
with the disease. Here we report the development of a customizable soft
robotic aortic sleeve that can mimic the haemodynamics...
As one of the highest energy consumer organs in the body, the heart requires tremendous amount of adenosine triphosphate (ATP) to maintain its continuous mechanical work. Fatty acids, glucose, and ketone bodies are the primary fuel source of the heart to generate ATP with perturbations in ATP generation possibly leading to contractile dysfunction....
Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. However, the regional microstructural tissue effects of these molecular mechanisms in the heart have yet to be spatially linked and further elucidated. We show in exercised mice that the expression of CITED4, a transc...
Cardiomyocyte growth can occur in both physiological (exercised-induced) and pathological (e.g., volume overload and pressure overload) conditions leading to left ventricular (LV) hypertrophy. Studies using animal models and histology have demonstrated the growth and remodeling process at the organ level and tissue–cellular level, respectively. How...
Purpose
For in vivo cardiac DTI, breathing motion and B0 field inhomogeneities produce misalignment and geometric distortion in diffusion-weighted (DW) images acquired with conventional single-shot EPI. We propose using a dimensionality reduction method to retrospectively estimate the respiratory phase of DW images and facilitate both distortion co...
Existing models of aortic stenosis (AS) are limited to inducing left ventricular pressure overload. As they have reduced control over the severity of aortic constriction, the clinical relevance of these models is largely hindered by their inability to mimic AS hemodynamics and recapitulate flow patterns associated with congenital valve defects, res...
Purpose:
To develop and assess a residual deep learning algorithm to accelerate in vivo cardiac diffusion-tensor MRI (DT-MRI) by reducing the number of averages while preserving image quality and DT-MRI parameters.
Materials and methods:
In this prospective study, a denoising convolutional neural network (DnCNN) for DT-MRI was developed; a total...
Citations
... Reports showed that the ingestion of ketone esters, such as (R)-3-hydroxybutyl (R)-3hydroxybutyrate, can rapidly raise blood ketone concentrations, mimicking the metabolic effects of a ketogenic diet [27,28] and show promise in surpassing the limitations of a ketogenic diet [29]. Ethyl 3-hydroxybutyrate (EHB) is a ketone ester, which was originally discovered as a flavoring compound in wine, that is commonly used as a food additive due to its pleasant aroma and fruity flavor, [29,30]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1157078085320704-1652880321064_Q64/Salva-Yurista.jpg)
... The model is enabled by two implantable soft robotic sleeves; an LV sleeve that re-creates the loss of LV compliance characteristic of HFpEF, and an aortic sleeve that can recapitulate changes in the afterload associated with most hemodynamic phenotypes of HFpEF (Fig. 1A). In previous studies, we demonstrated the ability of the LV sleeve to limit cardiac filling in an in vitro model of aortic stenosis and that of the aortic sleeve to recreate the hemodynamics of pressure overload in vitro and in vivo (50,51). Here, we redesign the LV sleeve for the development of the first porcine model of HFpEF capable of tuning pressure overload and ventricular compliance independently, in a facile, immediate, tunable manner, which allows us to re-create a broad spectrum of HFpEF hemodynamics. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1007952932659201-1617326114509_Q64/Luca-Rosalia-2.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/487811691356161-1493314778269_Q64/Jaume-Coll-Font.jpg)
... For example, Göktepe et al. (2010) simulated concentric and eccentric growth, Lee et al. (2015) extended the model to capture also reversal of growth. This model has also been used to reconstruct growth features from in vivo MRI (Fan et al. 2021) and has been coupled with 0D models of stimuli from hormonal signals (Estrada et al. 2020). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/403657473445891-1473250849982_Q64/Maaike-Van-Den-Boomen.jpg)
... Phipps et al. [18] used a residual-learning approach to de-noise the diffusion weighted images prior to the tensor calculation to reduce the number of acquisitions required to produce high-quality DT-CMR maps. In our previous work [21], our group also showed how a U-NET-based model can be successfully used to predict de-noised tensors directly from noisy images. ...
