Rik Vos's research while affiliated with Erasmus MC and other places

... The derived expression for the critical acoustic pressure, Eq. 5, reveals that the observed dependence of the threshold pressure on the resting bubble radius is a geometrical factor that results from the spherical shape of the phospholipid coating. In conclusion, we should mention that experiments reveal that the threshold behavior of phospholipid-coated microbubbles is dependent on the ultrasound parameters of the excitation pulse, such as the driving frequency f, the acoustic pressure amplitude P a , the number of pulses in the imposed ultrasound signal N, etc. Emmer et al., 2007b Emmer et al., , 2007c. In this connection it should be noted that Eq. 5 alone cannot explain such effects since they result from the rheological properties of a phospholipid layer as a material. ...

... Microbubbles loaded with AP-Cav size resulted in a polydisperse population with a range size of 1 to 2 µm. According to Kooiman et al. (2014), it is critical to consider the size of MBs to develop a stable cavitation process leading to microbubbles disruption. Size of MBs is also important because the close relationship between resonance frequency and MBs size. ...

... energy to a specific region. For a large impedance ratio resulting in a low energy transfer such as that met in liquid-gas interface problems, past studies have shown that the amplification of the amplitude of the transmitted wavefront can suffice to initiate phase change [19][20][21]. The latter mechanism results in characteristic cloud morphologies that agree remarkably well with the time-dependent wave structure shaped by the bubble lens effect. ...

... only few experimental studies address the echo of single microbubbles (for example, [11], [16]–[20]. In [16] and [17] , coated microbubbles were insonified with low-pressure pulses taking care to incorporate only bubbles that maintained their initial size. Bubble images were simultaneously recorded together with their echo signals. ...