Richard W Weber’s research while affiliated with National Jewish Health and other places

... In 1930, August Thommen set out five necessary principles, in order for a plant to be considered an important cause of pollinosis. First, the pollen must contain an excitant of hay fever, it must be anemophilous or wind-borne, it must be produced in sufficiently large quantities, it must be sufficiently buoyant to be carried for considerable distances and the plant producing the Urban allergy review: Allergic rhinitis and asthma with plane tree sensitization (Review) pollen must be widely and abundantly distributed (5). Pollens can be produced by grasses, weeds and trees. ...

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Urban allergy review: Allergic rhinitis and asthma with plane tree sensitization (Review)

... After antigen recognition, DCs migrate to lymph nodes and promote tolerance presenting the antigen to T cells. They are activated mainly by their innate immunity receptors, the Toll-like receptors (TLRs) [68], who are sensitive to intestinal bacterial proteins (mainly LPS), and in turn are conceivable targets for biologic therapies. TLRs may be stimulated by specific agonists as the TLR7 agonist R848, the TLR9 agonist CpG oligodeoxynucleotides, the TLR4 agonist monophosphoryl lipid A [69], or bacterial wall preparates used in other contexts [70]. ...

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Use of biologics in severe food allergies

... In this study, Mucor racemosus e voluminae cellulae (MR) was used, which is an active ingredient obtained from the mold Mucor racemosus. The spore-forming zygomycota from the order mucorales can live in versatile conditions, either in the form of yeast or mold, with the ability to survive at temperatures higher than 37 • C. It can cause severe human infections such as rhino-orbital-cerebral mucormycosis and allergic reactions like rhino-conjunctivitis [5][6][7][8]. Rhino-orbital-cerebral mucormycosis is an infection caused by spores of mold, often starting in the form of sinusitis and migrating to the eye socket and brain [5,9,10]. Infection can end in blindness or even death and is related to risk factors such as immunosuppression and diabetes [9,11]. ...

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Complement Component C5a and Fungal Pathogen Induce Diverse Responses through Crosstalk between Transient Receptor Potential Channel (TRPs) Subtypes in Human Conjunctival Epithelial Cells

... Most triatomine bugs are 12-to 36-mm long; are dark brown or black; and have what are called tigerstripe orange markings on the peripheral two-thirds of the body (Figure 1). 11 In contrast, wheel bugs commonly are bigger-measuring longer than 1.25 inches-and gray, with a cogwheel-like structure on the thorax (Figure 2). 10 ...

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What’s Eating You? Triatoma and Arilus cristatus Bugs

... While Monterey pine (Pinus radiata) has previously been linked as an allergenic species (Gastaminza et al., 2009;Harris & German, 1985), the allergenic status of Scots pine requires further research. As with pine, willow is not commonly regarded as a prevalent pollen aeroallergen (Weber, 2015), our results show that it can occur in relevant concentrations in certain regions, primarily Lillehammer and Oslo. A recent review has suggested that the pollen can contribute to moderate sensitization (Costache et al., 2021), showing its potential as an important aeroallergen in Norwegian regions in need of caution and further investigation. ...

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Allergenic pollen seasons and regional pollen calendars for Norway

... The genus Arthrinium has a worldwide distribution and has been described as plant pathogen, endophyte and saprobe (Bao et al. 2018) including marine habitats and also related to invertebrates, sponges and algae as a beneficial symbiont (Gunde-Cimerman et al. 2005;Bao et al. 2018). The same goes for the genus Periconia, that has been as well associated with marine habitats (Yamada et al. 2007), but also founded at the Atacama Desert (Sterflinger et al. 2012) or even Stemphylium, a saprophytic dematiaceous genus of hyphomycetes with a worldwide distribution, that can parasites plants (Weber 2015). This study could be considered the first report of isolates of these three genera in high altitude glaciers in Mexico. ...

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Richness and metallo-tolerance of cultivable fungi recovered from three high altitude glaciers from Citlaltépetl and Iztaccíhuatl volcanoes (Mexico)

... 127,129 Due to Acacia's close phylogenetic relationship to other allergenic members of the Fabaceae family (Fig. 2), such as Mimosa sp., mesquite (Prosopis sp.), and alfalfa (Medica sativa), there is a high likelihood of crossreactivity between these allergens. 127,130,131 Notedly, cross-reactivity with unrelated species, eg, ryegrass (Lolium perenne) and gladioli (Gladiolus gandavesis), have also been documented. 132 ...

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Monitoring, distribution and clinical relevance of airborne pollen and fern spores in Southeast Asia – A systematic review

... Festuca genus includes about 450 species. Annuals (Vulpia) and perennials (Eufestuca) are two important subgroups of Fescue grasses (Weber 2014). This pollen consists of different molecules such as Fes p1, 4, 5, and 13 (www.allergome.org). ...

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A meta-analysis of sensitization to the most common aeroallergens in a Middle Eastern region: an overview of the main molecular allergens

... 246,247 As with other fungi, F. graminearum and Fusarium verticilliodes produce allergens. 267 Exposure to grain dust from crops contaminated by these fungi potentially increases exposure to their allergens in workplaces. Similarly, A. flavus produces allergens. ...

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Miller 2024-24

... The safety of SCIT has been investigated in numerous surveillance studies and the risk factors for the occurrence of severe adverse reactions have been partially identified (6)(7)(8). When proper safety measures and precautions are implemented, SCIT results generally safe; however, for each preparation the benefits must be weighed also against the real risks of rare life-threatening allergic reactions and fatal anaphylaxis (9). Different research lines have been directed to promote the tolerability and patients' acceptance of this medical intervention. ...

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Efficacy and tolerability of house dust mites subcutaneous immunotherapy with monomeric allergoid: an Italian multicenter study