Richard B. Weininger's research while affiliated with Yale-New Haven Hospital and other places

Publications (2)

Article
Previous work has shown that (BALB/c x A)F, (CAF1) mice with an immunological disorder, the graft-versus-host reaction (GVHR), express an oncogenic murine leukemia virus (MuLV) which appears to be responsible for the subsequent development of lymphoreticular tumors. A mink cell focus-inducing (MCF) virus has been isolated from a reticulum cell neop...
Chapter
When a mammalian organism is immunized with an antigenic determinant, a highly complex humoral immune response is induced. This consists of a large number of antibodies complementary to the antigenic determinant. Such antibodies may vary in class and subclass. Furthermore, within a single subclass, there are differences in the energy of interaction...

Citations

... Whereas antigen binding does not seem to depend functionally on the Fc fragment, the latter reveals activity which in physiological conditions is triggered by attachment of the Fab fragment to the antigen. Some transfer of information must be postulated to explain such interdependence (1)(2)(3)(4). The structural character of this signaling has been accepted in studies since the very JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 2004, 55, 3, 487501 www.jpp.krakow.pl ...
... Of the NFS.V ϩ clonal B cell lymphomas tested, 90% contained novel somatic ecotropic integrations, a frequency consistent with MuLV insertional mutagenesis as an important lymphomagenetic mechanism. In marked contrast to T cell lymphomas, targeting of cellular oncogenes (Mucenski et al, 1987b) or involvement of MCF MuLVs has been reported only infrequently for B lineage tumors (Armstrong et al, 1980;Gilbert et al, 1993;Mucenski et al, 1987bMucenski et al, , 1988Pals et al, 1986;Thomas et al, 1990;Zijlstra et al, 1983Zijlstra et al, , 1986), but association of somatic ecotropic virus integrations in spontaneous pre-B or B cell lymphoma has been reported in certain AKXD RI strains (Gilbert et al, 1993;Justice et al, 1994;Mucenski et al, 1987a); CWD (Mucenski et al, 1988); SEA (Mucenski et al, 1988), C57BL , SL/Kh (Yamada et al, 1994), and in graft-versus-host reaction in CAF 1 mice (Pals et al, 1986). ...