Reto Erni's research while affiliated with ETH Zurich and other places

... the opposite phenotype of high-level overexpression; we recently have shown that limited overexpression of Grainyhead 1 (ghr-1) following transgene bombardment in C. elegans promotes longevity, whereas high-level overexpression of the same transgene shortens lifespan (49). ...

... This justifies why THC (and other molecules with partial or full agonistic activity on CB1, including the weak psychoactive D9-cis-THC enantiomer, recently demonstrated to occur naturally in Hemp-derived nutraceuticals, both phytocannabinoids and non-cannabinoids, with potential effects on the gastrointestinal tract and the brain-gut axis. (Schafroth et al., 2021), should be absent (or at low, non-psychotropic levels) in hemp-derived food products, as a minimum health safety requirement. With antagonistic or negative allosteric activity on CB1 receptors as an outstanding feature, the pharmacology of CBD is very complex (summarized in Table 5) and underlies its broad biological activities, including neuroprotection, analgesia, antiinflammatory and immune-modulating effects, anxiolytic, spasmolytic, anticonvulsant and antipsychotic effects, mood stabilization, and normalization of sleep disorders, just to name a few (Kicman and Toczek, 2020;Mlost et al., 2020;Britch et al., 2021;Franco et al., 2021;Vitale et al., 2021). ...

... Representative analogs from each of these three legends, compounds 5, 11, 13, 14 and 17, were selected, based on IC 50 values of 3.0 µg/mL or <3.0 µg/mL as a cut-off value against MRSA for MIC determination. Among the analogous of stemofuran A (1-5 and 17), pinosylvin (6)(7)(8)(9)(10)(11)(12)(13)(14), and resveratrol (15,16), compound 5, 11, and 17 exhibited the most potent activity against MRSA ATCC 1708, with IC 50 /MIC values of 1.18/2.50 µg/mL, 0.91/1.25 µg/mL, and 0.95/1.25 µg/mL, respectively. ...