September 2021
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53 Reads
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6 Citations
Clinical Oral Implants Research
Objectives The primary objective of this study was to assess whether giving postoperative antibiotics to healthy patients after straightforward platform-switched implant placement would influence peri-implant crestal bone levels and postoperative morbidity after one year. Methods Thirty-eight healthy individuals were recruited in this pilot, randomized, double-blinded, placebo-controlled clinical trial. The intervention group (n=18) received two grams of amoxicillin one hour before implant placement followed by a seven-day postoperative regimen (500 mg tid). The control group (n=20) took the same preoperative dose of amoxicillin and an identical placebo postoperatively. Mesial and distal peri-implant crestal bone levels were measured at baseline, four months and one year later with standardised periapical radiographs. Postoperative pain severity was assessed through self-administered questionnaires for seven days. Surgery-associated morbidities were evaluated after one, three, 16 weeks and one year. Descriptive and bivariate analyses were used. Results Thirty-seven participants completed the trial. At the one-year follow-up, the mean combined peri-implant crestal bone changes for the intervention (n=18) and control (n=19) groups were - 0.44 ± 0.41 mm and - 0.27 ± 0.56 mm, respectively. The difference between the groups (intervention-control) for mean combined crestal bone level changes was not statistically significant. There were no significant differences in surgery-associated morbidities between the intervention and control groups. The one-year implant survival rate was 100% in both groups. Conclusions Study results suggest that a routine postoperative antibiotic regimen for healthy patients undergoing straightforward platform-switched implant placement might not be necessary to prevent postoperative peri-implant bone loss and complications.