Réjean Dion's research while affiliated with Institut National de Santé Publique du Québec (INSPQ) and other places

Publications (23)

Article
Full-text available
Background The coronavirus disease (COVID-19) pandemic has affected residents in long-term care facilities (LTCF) significantly. Understanding transmission dynamics in this setting is crucial to control the spread of COVID-19 in this population. Using whole genome sequencing (WGS) of SARS-CoV-2, we aimed to delineate the points of introduction and...
Article
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Background Québec was the Canadian province most impacted by COVID-19, with 401,462 cases as of September 24th, 2021, and 11,347 deaths due mostly to a very severe first pandemic wave. In April 2020, we assembled the Coronavirus Sequencing in Québec (CoVSeQ) consortium to sequence SARS-CoV-2 genomes in Québec to track viral introduction events and...
Preprint
Full-text available
Using genomic epidemiology, we investigated the arrival of SARS-CoV-2 to Québec, the Canadian province most impacted by COVID-19, with >280,000 positive cases and >10,000 deaths in a population of 8.5 million as of March 1st, 2021. We report 2,921 high-quality SARS-CoV-2 genomes in the context of >12,000 publicly available genomes sampled globally...
Article
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The aim of this study was to describe the epidemiology of human cryptosporidiosis in Québec from 2016 to 2017 and to identify possible exposures associated with the disease, and the dominant Cryptosporidium species in circulation. A descriptive analysis was performed on data collected from the provincial notifiable infectious diseases registry and...
Article
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We conducted a recent investigation in Quebec, Canada, concerning Canadian deer hunters who went to the United States to hunt deer and returned with symptoms of fever, severe headache, myalgia, and articular pain of undetermined etiology. Further investigation identified that a group of 10 hunters from Quebec attended a hunting retreat in Illinois...
Article
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Background: Molecular phylogenetics are generally used to confirm hepatitis C virus (HCV) transmission events. In addition, the Laboratoire de santé publique du Québec (LSPQ) has been using molecular phylogenetics for surveillance of HCV genotyping since November 2001. Objectives: To describe the emergence of a specific lineage of HCV genotype 4...
Article
Background: Molecular phylogenetics are generally used to confirm hepatitis C virus (HCV) transmission events. In addition, the Laboratoire de santé publique du Québec (LSPQ) has been using molecular phylogenetics for surveillance of HCV genotyping since November 2001. Objectives: To describe the emergence of a specific lineage of HCV genotype 4d (...
Article
Background: A small village in Nunavik, Quebec experienced a tuberculosis (TB) outbreak in 2012-2013 and then a resurgence in 2015-2016. Cases were still occurring, despite the fact that contact tracing had already been conducted on one quarter of the population. A decision was taken to conduct large-scale screening of the population for TB. Obje...
Article
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A matched case-control study in Quebec, Canada, evaluated consumption of veal liver as a risk factor for campylobacteriosis. Campylobacter was identified in 28 of 97 veal livers collected concurrently from slaughterhouses and retailers. Veal liver was associated with human Campylobacter infection, particularly when consumed undercooked.
Article
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Background Owing to a persistent increase of serogroup B Neisseria meningitidis (Nm) invasive infections in the Saguenay-Lac-Saint-Jean (SLSJ) region of the province of Quebec (Canada) since 2006, a wide-scale vaccination campaign of individuals aged 6 months to 20 years was conducted between May and December 2014 using the 4-component protein-base...
Article
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Legionella is found in natural and man-made aquatic environments, such as cooling towers and hot water plumbing infrastructures. Legionella pneumophila serogroup 1 (Lp1) is the most common etiological agent causing waterborne disease in the United States and Canada. This study reports the molecular characterization of Lp strains during a 10 year pe...
Article
Full-text available
Cryptosporidium is a leading cause of childhood diarrhea in low-resource settings, and has been repeatedly associated with impaired physical and cognitive development. In May 2013, an outbreak of diarrhea caused by Cryptosporidium hominis was identified in the Arctic region of Nunavik, Quebec. Human cryptosporidiosis transmission was previously unk...
Conference Paper
Background: In 2012, a major L. pneumophila serogroup 1 (LP1) outbreak occurred in Quebec city, Canada, causing 181 reported cases including 13 fatalities. LP is a ubiquitous Gram-negative bacteria within freshwater and manmade aquatic environments such as cooling tower systems and spas. Infection in human occurs though inhalation of droplets carry...
Article
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The analytical studies used to investigate foodborne outbreak are mostly case-control or retrospective cohort studies. However, these studies can be complex to perform and susceptible to biases. This article addresses basic principles of epidemiology, probability, and the use of case-case design to identify the source of an Escherichia coli O157:H7...
Article
Sporadic community-acquired legionellosis (SCAL) can be acquired through contaminated aerosols from residential potable water. Electricity-dependent hot-water tanks are widely used in the province of Quebec (Canada) and have been shown to be frequently contaminated with Legionella spp. We prospectively investigated the homes of culture-proven SCAL...
Article
Full-text available
During periods of endemic meningococcal disease, serogroup B Neisseria meningitidis is responsible for a significant percentage of invasive diseases, and no particular clone or strain predominates (F. E. Ashton and D. A. Caugant, Can. J. Microbiol. 47: 293-289, 2001), However, in the winter of 2004 to 2005, a cluster of serogroup B meningococcal di...
Article
Ten years after a school-based hepatitis B immunization program was implemented, we conducted a study to assess the impact of the program, vaccine failures, risk factors and the number of cases potentially preventable by the addition of an infant vaccination program. The preteen vaccination program is highly effective. An infant immunization progra...
Article
Background Among the factors influencing travelers to seek preventive health advice before departure, the travel agent's recommendation plays an important role. The objective of our study was to document the practices and needs of travel agents in Québec (Canada) in relation to the prevention of health problems among travelers. Methods In June 200...
Article
Among the factors influencing travelers to seek preventive health advice before departure, the travel agent's recommendation plays an important role. The objective of our study was to document the practices and needs of travel agents in Québec (Canada) in relation to the prevention of health problems among travelers. In June 2000, a cross-sectional...

Citations

... OPEN determine whether rising COVID-19 infections are driven by one or more super spreader events (e.g., large social gatherings or conferences), congregate living accommodations (e.g., dormitories or care homes), new introductions from outside sources (e.g., due to holiday travel), introduction of a new variant with increased infectivity (e.g., the Omicron variant), or other factors [17][18][19][20][21][22] . For IHEs, this information can be used to identify risk factors for increased transmission throughout the academic year, and to help develop effective mitigation measures for future outbreaks of COVID-19 or other pathogens with similar transmission mechanisms. ...
... Thirty-four outbreaks of clinical toxoplasmosis in humans have been documented throughout the past 50 years [4]. In immunocompetent people, symptoms are minimal and mimic the flu [4][5][6]. On the other hand, toxoplasmosis is considered as a serious condition among those with compromised immune systems [2]. In both HIV-positive and non-HIV immunocompromised individuals, the most frequent clinical symptom caused by T. gondii infection is toxoplasmic encephalitis (TE) [2]. ...
... The viremic prevalence in Canada was estimated to be 0.6% (0.4-0.7) in 2015 (22), as shown in Figure 1 and Table 1. From 2012 to 2018, there was a decline from 1% to 0.6% in viral prevalence due to the introduction of public health insurance and treatment initiation with DAAs in Canada (22,23,24). ...
... Phylogenetic trees were built using the maximum likelihood analysis and employing a general time-reversible (GRT) substitution model implemented using the Molecular Evolution Genetic Analysis (MEGA) software v. 10 [20]. Sequences were associated with a particular cluster if the nucleotides differed by less than 3% and the bootstrap support value was greater than 70% [21]. Monophyletic clusters and phylogenetic trees were derived from sequences that clustered using the maximum likelihood method. ...
... People with a TST result of at least 5 mm or who had a history of LTBI or active TB underwent chest radiography. 15 The NRBHSS worked with local staff as well as staff flown in to the villages to organize these screening campaigns. Additional details are provided in the Screening campaigns section of Appendix 1, available at www.cmaj.ca/lookup/ ...
... Generally, Campylobacter resides in the intestine of warm-blooded animals, transmitting it to humans through contaminated food items [6]. Campylobacter species, including C. coli, C. jejuni, and C. fetus are commonly residing in the intestinal contents of bovine, their bile, gallbladder, bile ducts and liver [7]. Campylobacter jejuni is thermophile in nature, maximum growth at 42°C in 3-15% of oxygen and a CO2 concentration of 2-10%. ...
... Recently, outer membrane vesicle (OMV) vaccines against capsular group B Neisseria meningitidis (MenB) was shown to crossprotect against N. gonorrhoeae. This finding suggests that it is possible to induce protection against gonococcus, reigniting efforts to develop a specific vaccine for gonorrhea (10)(11)(12). Further investigation is needed as both the antigens involved and the immune mechanisms of protection are unclear. ...
... Moreover, the predominant ST 338 and ST 336 were found both in hotels and in residential buildings. Several STs identified in our study have been associated with LD outbreaks and sporadic cases in other countries [55,56]. In addition, we did not find differences between the STs found in buildings with and without LD cases, and all these findings consequently suggest that Legionella strains may persist in residential buildings in Latvia and pose a long-term risk to residents. ...
... According to a previous study, the Ib subtype family was the most frequent in North America, followed by Ia, Id, and Ie 22 . However, in these studies, subtype IeA11G3T3, an Ie subtype family member, was the second most frequently reported 16,25,26 . Considering the number of different members of each subtype family, the Id subtype family, with 14 different subtypes, was also reported 16,25,26 . ...