Razieh Mohamad Jafari’s research while affiliated with Ahvaz Jundishapur University of Medical Sciences and other places

This study was designed to compare results of Pap-smear and colposcopy and histopathology in women with Post Coital Bleeding (PCB) at any age. A cross-sectional study conducted on 50 women with PCB. Patients were referred to Colposcopy Clinic of Imam Khomeini Hospital (University affiliated), Ahvaz, Iran in 2013. Demographic data, cytological, colposcopic and histopathology results were recorded. Cytological results were classified into normal, inflammatory, high grade squamous, Atypical Glandular Cells (AGC), Low Grade Intraepithelial Lesions (LSIL) and Interepithelial lesions. Colposcopic findings were reported as normal, abnormal, unsatisfactory and invasive carcinoma suspicious. In all cases, Papanicolaou smears and colposcopy were performed by the same skilled gynecologist. We evaluated 50 patients with PCB. The mean age of patients was 33.66±5.54. Of 50, 8(16%) patients were below than 40 years. 23 (46%) of patients did not use any contraceptive. Comparison of the mean score of age between normal and abnormal histopathological results did not show statistically significant difference (33.55±3.38, 33.69±6.04 years, respectively, p value = 0.9). The PCB was never seen in nulliparous, while it had high frequency in multipara 47 (96%) patients. Normal and abnormal histopathological results showed significance difference regarding multipara risk factor (11(22%) and 36(72%), respectively, p value <0.0001). In summary, our findings mostly were consistent with previously published literature in other population groups. Especially, our results regarding invasive cancer in women with PCB alarm us to investigate such cases using colposcopy and histopathology.

Background: Previous investigations have shown that pregnancy-associated plasma protein-A (PAPP-A) levels are associated with adverse pregnancy outcomes including intrauterine growth restriction (IUGR) fetuses as well as preterm delivery. The aim of this study was to determine the rate of preterm delivery in women with low PAPP-A and at intermediate risk for chromosomal abnormalities in the first trimester screening. Methods: A total of 137 women who underwent Down syndrome screening between 11 to 14 weeks of gestation were studied from September 2011 to September 2013 at Perinatal Care Clinic, Imam Khomeini Hospital, Ahvaz, Iran. From those, 52 patients had low PAPP-A. Inclusion criteria were singleton pregnancies, at 11 to 14 weeks of gestation, at intermediate risk for Down syndrome (risk in 1:101 to 1:1000). The intermediate risk was estimated based on maternal parameters, maternal serum markers (PAPP-A and β-hcG), and nuchal translucency (NT) using fetal medicine foundation (FMF), UK) software. The power of the study was 90%. The sample size was estimated based on prevalence of preterm delivery in pregnancies with low PAPP-A in the first trimester screening. Patients were followed-up until delivery to observe pregnancy outcomes. We evaluated the variables such as level of PAPP-A, outcomes of delivery, age, β-hCG, and gestational age. Results: Among 137 normotensive pregnant women at intermediate risk for Down syndrome, 52 cases (38%) had low PAPP-A (