Ravindra D Gupta’s research while affiliated with Duke University Medical Center and other places

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Publications (1)


Figure 2: Activation of caspase-3 and caspase-7 by solar-simulated irradiation and relative protection by antioxidant formulations. Skin was pretreated with vehicle, 0.5% ferulic acid, 15% vitamin C and 1% vitamin E, 15% vitamin C and 1% vitamin E, and 0.5% ferulic acid and exposed to 4 × and 8 × minimal erythema dose (MED). Levels of of caspase-3, caspase-7, and α-tubulin were determined after 24 h. Relative caspase-3 or caspase-7 levels corrected for α-tubulin are presented (n=3). (a) Western blot of caspase-3 after 4 × and 8 × MED and relative antioxidant protection. (b) Densitometric levels of caspase-3 and relative antioxidant protection (n=3). (c) Western blot of caspase-7 after 4 × and 8 × MED and relative antioxidant protection. (d) Densitometric levels of caspase-7 and relative antioxidant protection (n=3).
Figure 5 Effect of dosage on photoprotection provided by vitamins C, E, and ferulic acid. Skin was pretreated by 75, 150, and 250 m L of 15% vitamin C, 1% vitamin E, and 0.5% ferulic acid and irradiated with solar-simulated radiation 1 Â to 5 Â minimal erythema dose (MED) at 1 Â MED intervals. Evaluation was carried out 1 d later. ( a ) Colorimeter measurements of photoprotection by vitamins C, E, and ferulic acid (n 1⁄4 3). ( b ) Sunburn cell measurements of photoprotection by vitamins C, E, and ferulic acid (n 1⁄4 3). 
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Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin
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November 2005

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4,564 Reads

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344 Citations

Journal of Investigative Dermatology

Fu-Hsiung Lin

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Jing-Yi Lin

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Ravindra D Gupta

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[...]

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Sheldon R Pinnell

Ferulic acid is a potent ubiquitous plant antioxidant. Its incorporation into a topical solution of 15%l-ascorbic acid and 1%alpha-tocopherol improved chemical stability of the vitamins (C+E) and doubled photoprotection to solar-simulated irradiation of skin from 4-fold to approximately 8-fold as measured by both erythema and sunburn cell formation. Inhibition of apoptosis was associated with reduced induction of caspase-3 and caspase-7. This antioxidant formulation efficiently reduced thymine dimer formation. This combination of pure natural low molecular weight antioxidants provides meaningful synergistic protection against oxidative stress in skin and should be useful for protection against photoaging and skin cancer.

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Citations (1)


... limited by their structural instability and low antioxidant efficiency [9][10][11]. As is well known, there are two levels of antioxidant systems in our skin: relatively inefficient nonenzymatic defenses and highly efficient enzymatic defenses. ...

Reference:

Transdermal Delivery of Baicalin Based on Bio‐Vesicles and Its Efficacy in Antiaging of the Skin
Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin

Journal of Investigative Dermatology