Randolf Klingebiel's research while affiliated with Bielefeld University and other places

... Despite the clear information about clinical assessment, however, no guidelines were provided on the video-oculographic (VOG) examination, probably due to the paucity of data on this topic. The VOG is a well-recognized and accepted technique, but surprisingly few studies investigated its performances in the differential diagnosis between PSP and other parkinsonian syndromes [2][3][4]. A recent VOG study [5] in 100 PSP patients demonstrated that the reduction of peak velocity of vertical saccades was highly specific for differentiation of PSP patients from control subjects, but this parameter showed very low sensitivity (around 60%), thus limiting its usefulness in PSP diagnosis. ...

... Zuhorn et al. [9] recently reported on 3 cases of postvaccinal autoimmune encephalitis following ChAdOx1 nCov-19 vaccination. In their additional analysis of the publicly available database, they estimated the incidence of such a possible association to be 0.1 per 100,000 vaccinations for the ChAdOx1 nCov-19 and 0.04 per 100,000 vaccinations for the mRNA vaccine (Comirnaty) [9]. ...

... This neuropsychological syndrome is thought to be caused by a transient disturbance in hippocampal function [2,3]. In addition, it reflects a reversible disruption of the functional connectivity of the broader episodic memory network, including the medial temporal sub-network, as well as the orbitofrontalcingulate, inferior temporal, medial occipital, and deep-structure sub-networks [4][5][6]. ...

... Among the COVID-19 vaccines, the AZD1222 vaccine, an adenovirus-based viral vector vaccine, is associated with a higher risk of developing post-vaccination encephalitis than the BNT162b2 vaccine, an mRNA vaccine (13). In fact, 19 of the 24 patients with MOGAD following COVID-19 vaccinations (79.2%) had been inoculated with AZD1222 vaccines, as shown in Table. ...

... The aim of the present study was to analyse sex-specific differences of TGA patients in a large retrospective cohort of a tertiary referral centre. In previous studies, we were able to show differences between TGA patients and acute stroke patients as well as differences between TGA patients with and without subsequent recurrence [6,21]. It was shown that TGA patients, regardless of sex, had significantly higher blood pressure values on admission compared to acute stroke patients, but were less likely to present with signs of chronic hypertension [21]. ...

... Cholesterol granulomas encompass the most frequent destructive lesion of the petrous apex. 1 Cholesterol granulomas form when the aeration of the petrous apex is hindered, thus creating a vacuum into which blood is drawn, causing foreign body giant cell reaction to cholesterol deposits, with fibrosis. 2 They are ten times more common than cholesteatomas and forty times more common than petrous apex mucoceles. ...

... In addition, due to partial thrombosis of the superior mesenteric artery causing bowel ischemia, we began the treatment of extensive portal vein thrombosis after the large ileal enterectomy. To manage VITT, treatments such as anticoagulation, high-dose intravenous immune globulin (IVIG), therapeutic plasma exchange (TPE), corticosteroids, rituximab, and eculizumab have been used [18,20,23,37,[44][45][46][47][48]. In addition, many patients received transfusions of supportive blood products such as platelets and fibrinogen concentrate or cryoprecipitate. ...

... COVID-19-associated encephalitis-produced hyperintensities (ranging from punctate to diffuse) have been reported in multiple regions of the brain (subcortical white matter, brainstem, and claustrum) (14), though deterioration within the claustrum (''Claustrum Sign'') is usually only present in immune-inflammatorymediated encephalopathy or autoimmune epilepsy (28). Clinical overlap also exists with herpes simplex encephalitis (HSV encephalitis) (29,30). ...

... While these cases are noteworthy and should serve as cautionary information for clinicians, such adverse effects would likely be reported in more literature if they were widely prevalent. Some of these severe events included iron deficiency anemia, intraperitoneal hemorrhage, and cervical artery dissection [25,28,29]. Once again, these cases were the result of improperly trained clinicians using flawed methodology. ...