Rajeshwar Nitiyanandan's research while affiliated with Arizona State University and other places

Publications (8)

Article
Surgical-site infections occur in 2-5% patients undergoing surgery in the US alone, impacting 300,000-500,000 lives each year, and presenting up to 11 times greater risk of death compared to patients...
Article
Copper ions play an important role in several physiological processes, including angiogenesis, growth factor induction and extracellular matrix remodeling, that modulate wound healing and tissue repair. In this work, copper-loaded alginate fibers were generated and used as surgical sutures for repair of incisional wounds in live mice. Approximately...
Article
Sutures are typically the primary means of soft tissue repair in surgery and trauma. Despite their widespread use, sutures do not result in immediate sealing of approximated tissues, which can result in bacterial infection and leakage. Nonabsorbable sutures and staples can be traumatic to tissue, and the trauma can be exacerbated by their subsequen...
Article
Effective transgene expression in mammalian cells relies on successful delivery, cytoplasmic trafficking, and nuclear translocation of the delivered vector, but delivery is impeded by several formidable physicochemical barriers on the surface of and within the target cell. Although methods to overcome cellular exclusion and endosomal entrapment hav...
Article
Full-text available
Exosomes are nanoscale extracellular vesicles (EVs) that are shed from different cells in the body. Exosomes encapsulate several biomolecules including lipids, proteins, and nucleic acids, and can therefore play a key role in cellular communication. These vesicles can be isolated from different body fluids and their small sizes make them attractive...
Article
Full-text available
Targeted delivery of anticancer therapeutics can potentially overcome limitations of poor drug bioavailability, drug resistance, and off-target side-effects that are associated with current chemotherapeutic regimens. Folate receptors are overexpressed on several types of cancer cells including, ovarian, non-small cell lung, triple-negative breast a...

Citations

... Additional virulence determinants included open reading frames for the luxA/C siderophore, lysostaphin protein A, and msrA macrolide efflux pump genes. Generally, the strain SQL1/USA300 data presented advance our ongoing development of novel MRSA infection treatment strategies (13)(14)(15)(16). ...
... Given this, to solidify the NADESs, eutectogels enabled by gelling the NADESs (Zeng et al., 2020) are expected to be fabricated using safe, biodegradable and nontoxic backbone materials. As water-insoluble calcium alginate (CA) hydrogels have good biocompatibility, high safety and suitable mechanical properties (Ghosh et al., 2020;Xin et al., 2020), which are widely used in the food and biomedical fields to load functional substances (Gholamian et al., 2021;Song et al., 2020;Wu et al., 2020), NADESs-incorporated CA (NADESs@CA) eutectogels are proposed to be fabricated, hoping to explore a greener way of bio-inspired anti-freezing materials in the frozen food industry. ...
... SAM RNA may be effective at lower doses for a number of reasons. Whereas DNA needs to enter the nucleus, RNA only needs to enter the cytoplasm to be transcribed (36)(37)(38). The SAM replicon is designed for enhanced amplification of RNA transcripts from which antigen can be expressed and produces dsRNA, which provides a self-adjuvanting effect through activation of pattern recognition receptors (e.g., TLR3, RIG-I, and MDA-5) likely contributing to the efficacy of the SAM vaccine. ...
... The cells from which exosomes are separated, the production of exosome vesicles, cargo loading techniques, the selection of targeting biomolecules (e.g., peptides) on the surface, biodistribution and immune response are all important elements to consider in future translational applications involving exosomes [102]. Loading of small-molecule medications can be efficient, while there is potential for improvement in case of loading DNA/siRNA. ...
... Two mechanisms of FA uptake have been identified: 1) reduced folate carrier (RFC1) promotes endocytosis of folic acid in a reduced form by cells and 2) high-affinity folate receptor recognizes folic acid and promotes its oxidation by cells through receptor mediation. Folic acid that enters the cell through this pathway is released into the cytoplasm through endosomal acidification (Godeshala et al., 2016). FR has been shown to be overexpressed in a number of human tumor types, including triple-negative breast cancer, ovarian cancer, and non-small cell lung cancer. ...