Raed A. Joundi's research while affiliated with McMaster University and other places

... The trial used deferred consent procedures wherever approved by local research ethics boards. 16,17 Two centres, in the province of Quebec, Canada, used only prospective consent (written or verbal) from patients or their representatives. At the remaining centres where consent was deferred, patients or their legal representatives were asked to provide written or electronic informed consent as soon as possible after treatment, within 7 days of randomisation, or before discharge, whichever was earlier. ...

... A recent multicenter study utilizing the Get With The Guidelines-Stroke nationwide United States registry, which included 3,015 BAO patients, showed that onset-to-EVT time <6 hours was significantly associated with lower in-hospital mortality (aOR, 0.55; 95% CI, 0.45 to 0.68) and sICH (aOR, 0.52; 95% CI, 0.32 to 0.84) rates, and a higher rate of independence at discharge (aOR, 2.21; 95% CI, 1.66 to 2.95) than those with >6 hours. 78 The fastest decline of good outcomes per hour occurred within 6 hours of symptom onset. Regarding late-window treatment, imaging-based patient selection utilizing the core-penumbra mismatch concept is currently less established in PC-EVT. ...

... The direct imaging of thrombus is, therefore, of great importance. In clinics, CT and MRI are the major methods used [157,158]. Traditional CT and MRI (with or without a contrast agent) diagnoses of thrombosis are usually based on visualizations of the reduction of the blood flow within the vessel lumen, instead of the thrombus itself [159]. They thus cannot differentiate between a thrombus and atherosclerosis as both can obstruct blood flow [160]. ...

... We adjusted for age, gender, race, and comorbidities using multiple Poisson regression model. We used Kendall's tau-b (s b ) to determine strength and direction of trends in annual CDI prevalence, mortality, and severity [12]. ...

... As a result of poorer health education, women may not recognize the symptoms of stroke, and activation of emergency medical serves may be delayed. suggests that women experience less pain and discomfort compared with men after EVT, 58 which is only moderately associated with the mRS score 59 because the mRS is heavily weighted on motor function and does not capture discomfort and anxiety. Poststroke depression, on the other hand, is more commonly seen in women. ...

... With respect to HRQoL, patients in the therapy group had a significantly lower EQ VAS compared to the stroke patients without acute therapy, but after adjustment for confounding variables, patients having profited from recanalization therapies did not have a significantly different EQ VAS compared to the patients with stroke unit therapy only, neither in the subacute phase nor in the follow-up period. At first glance, this was rather surprising, as another study could detect a prominent treatment effect, especially for endovascular therapy (23). As functional deficits and HRQoL correlate in stroke patients (24), the strong functional improvement during hospitalization in our treated patients might explain the low treatment effect in the statistical analysis of the present cohort. ...

... Oral conversation was regained in six (20%) of the patients [7,20,25,27,28,32,42,43]. In two patients, CD was transient, one following a bilateral middle cerebral vasospasm secondary to an aneurysm rupture [30] and the other two after a unilateral ischemic stroke [38,40]. ...

... According to the Global Burden of Disease Study, a significant increase in stroke prevalence and incidence rates in terms of ischemic stroke (IS) was found in both men and women aged under 70 years between 1990 and 2019, with even faster increases observed from 2010 to 2019 [1]. A stable or increasing trend in stroke incidence among middle-aged people was recently observed in the USA, Canada, Australia, and European countries including France [3][4][5][6][7][8][9][10]. Several studies have predicted a substantial increase in the number of stroke cases in high-income countries by 2030 and 2050, associated with almost a doubling of healthcare costs related to stroke by then [1,[11][12][13], as supported by projections from the Dijon Stroke Registry for France [14]. ...

... 26,27 In contrast, there was a decrease in the use of feeding tubes for both ischemic stroke and ICH, consistent with a US study that showed decreased feeding tube usage from 2002 to 2012. 9 The dissociation in trends between ICU care and feeding tube use may be attributed to improvements in acute stroke care and subsequent disability, reducing the prevalence of severe dysphagia at 2 to 3 weeks, when feeding tubes are typically placed in Canada, 28 or an increase in the use of palliative care or care limitations. Importantly, we observed an approximate doubling in the absolute numbers of patients with first acute stroke requiring ICU care across the 15-year study period, from 1054 per year to 2017 per year, highlighting the increasing resource need for ICU and post-ICU care among patients with stroke. ...

... Several studies have investigated predictive factors for dysphagia recovery in stroke patients including age [7,12,[15][16][17], sex [18,19], body mass index (BMI) [12,20], the National Institute of Health Stroke Scale score [19,[21][22][23][24][25], stroke location [17,21,23,24], the Functional Independence Measure score [7,15,18,20], multiple comorbidities [17], and intubation [24]. However, most previous studies were conducted at a single institution with a limited number of patients, and numerous factors could not be analyzed simultaneously. ...