Rachita Dhurat's research while affiliated with Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College and other places
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Publications (90)
Introduction
Previously laid down criteria for lesional stability of vitiligo are inconsistent. Longitudinal data on correlation between dermoscopic features of vitiligo and disease activity is limited.
Objectives
To sequentially determine the dermoscopic features of vitiligo and to assess their association with the dynamic nature of the vitiligo...
Background and aims
Diagnosing end-stage primary cicatricial alopecia (PCA) on routine histology is challenging since the major diagnostic feature (inflammatory infiltrate) may be minimal or absent. This study aimed to assess various staining patterns and diagnostic utility of elastic tissue staining by Verhoeff-Van Gieson (VVG) method and trichosc...
Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the epidermis, dermis, and subcutaneous tissue, resulting in various cutaneous manifestations. A young girl presented with multiple painful hard indurated nodules and plaques over the abdomen, back, breast, and bilateral lower limbs for 4 months. Biopsy showed a de...
Eosinophilic cellulitis (Wells syndrome) is an inflammatory dermatitis that is often misdiagnosed as infectious cellulitis due to its similarity in presentation. Misdiagnosis leads to delay of correct treatment and inappropriate use of antibiotics. The clinical eruption is characterized by varying morphology and severity and usually follows a relap...
Alopecia areata is an autoimmune condition which usually presents as non-scarring patchy alopecia. The disease has varied clinical presentations ranging in severity from patchy circumscribed alopecia, reticular pattern, ophiasis, sisaipho, diffuse, or incognito type to alopecia totalis and alopecia universalis. The various available treatment optio...
p>Female pattern hair loss (FPHL) is a common cause of hair loss and is associated with a reduction in quality of life and psychological morbidity. It is characterised by nonscarring progressive thinning of hair with gradual reduction in the number of hairs, with prevalence increasing with advancing age. A differential diagnosis of FPHL includes co...
Background
Cutaneous manifestations of COVID-19 may be useful disease markers and prognostic indicators. Recently, post-infectious telogen effluvium and trichodynia have also been reported.
Objective
To evaluate the presence of trichodynia and telogen effluvium in patients with COVID-19 and describe their characteristics in relation to other signs...
Background:
Hair transplantation in scarring alopecia is challenging and transplant surgeons are hesitant due to fear of poor graft survival apart from the risk of reactivating the disease.
Objective:
Survival rate of hair follicles transplanted in cases of lichen planopilaris (LPP). To correlate histopathological and ultrasonography findings an...
Background
Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide, but lacks clear aetiology and robust clinical trial evidence for efficacy and safety of agents currently used for treatment.
Objectives
To enable data to be collected worldwide on FFA using common criteria and assessment methods....
Tinea capitis is a common fungal infection in children but is less frequently encountered in adults. Tinea capitis presenting as diffuse hair loss is a rare presentation. When patient presents with a diffuse hair loss, tinea capitis is not commonly thought of as differential diagnosis. Low clinical suspicion can lead to inappropriate empiric treatm...
Background
Minoxidil is a widely used over the counter topical treatment for hair loss. The response rate for topical minoxidil is relatively low. Minoxidil is a pro-drug, converted to its active form, minoxidil sulfate, by SULT1A1 enzymes located in the scalp. Recently, a novel topical formula that increases the activity of SULT1A1 in hair follicl...
Androgenetic alopecia (AGA) is the most common form of hair loss in men and women. Although female pattern hair loss (FPHL) and male AGA share a final common pathway that causes follicular regression but current knowledge suggests that the etiology is not necessarily the same in both sexes. There are many known and unknown factors that govern the d...
Importance:
A recent expert consensus exercise emphasized the importance of developing a global network of patient registries for alopecia areata to redress the paucity of comparable, real-world data regarding the effectiveness and safety of existing and emerging therapies for alopecia areata.
Objective:
To generate core domains and domain items...
Importance: A recent expert consensus exercise emphasized the importance of developing a global network of patient registries for alopecia areata to redress the paucity of comparable, real-world data regarding the effectiveness and safety of existing and emerging therapies for alopecia areata. Objective: To generate core domains and domain items fo...
Acne vulgaris (AV) is the most common skin condition affecting adolescents, most likely due to elevated androgen levels during puberty. Androgens stimulate and enlarge the sebaceous glands and keratinocytes, resulting in increased production of sebum and abnormal hyperproliferation of keratinocytes which lead to the formation of acne lesions. Curre...
The lips are considered of great importance for the perception of beauty and thereis still a lacuna in the attempt to successfully re-pigment resistant areas of vitiligo especially the lips.Notechnique evolved so far ensures 100% pigmentation with a good cosmetic appearance. To study the efficacy and cosmetic outcome following primary excision and...
Introduction:
Many dermatological conditions require extraction of material from the lesion followed by visualization under a microscope. However, visualization of the extracted material can be done using a dermoscope instead. We propose "extraction dermoscopy" as an addition to the already existing treasury that dermoscopy holds.
Methods:
After...
Lichen simplex chronicus (LSC) is characterized by lichenification of the skin because of primary excessive scratching. Herein, we present two cases of scalp LSC with a patch showing localized hair loss and paroxysmal severely itching on that area. Dermoscopy examined the presence of broom hair fibers while histopathological examination revealed ge...
Background
Approximately, 13.5% of the population suffers from chronic itch. Many cosmetic and pharmaceutical treatments for itch are available; however, cosmetic treatments are not reliably effective and most pharmaceutical formulations carry the risk of adverse events with chronic use.
Aims
Previously, we have reported a novel extraction process...
Androgenetic alopecia (AGA) is a multi‐factorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5‐alpha reductase (5‐AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finas...
The problem of side‐effects of injectable corticosteroids has gradually become more acute with rampant and unlimited misuse of the drug particularly by non‐dermatologists. Serial saline injections at the site of steroid induced lipoatrophy in a child served as a safe, relatively rapid and cost‐effective solution.
This article is protected by copyri...
https://onlinelibrary.wiley.com/doi/full/10.1111/dth.13365
Median raphe cyst (MRC) is an uncommon, asymptomatic benign lesion, that may present anywhere on the midline ridge between the external urethral meatus and the anus. Although they are developmental in origin, they often present in the postpubertal age, aggravated by trauma, and are frequently infected secondarily. MRCs are often misdiagnosed as epi...
More often than not, difficulty is faced while performing onychoscopy due to the peculiar anatomy and convexity of the nail. Onychoscopy serves as a window to the armamentarium of nail disorders with a potential to prevent biopsy. We describe a simple, inexpensive, easy to reproduce framework using an ointment carton.
Atrophia maculosa varioliformis cutis (AMVC) is a sporadic or inherited childhood disorder, signified by the occurrence of pitted scars, usually over the face. We report two cases of AMVC occurring in monozygotic twins.
Soft, spongy or doughy consistency of the scalp resulting from thickening of the subcutaneous layer is termed as lipedematous scalp (LS). When such soft, boggy scalp is associated with hair loss, where the scalp hair is no longer than a few centimeters, it is referred as lipedematous alopecia (LA). There have been coincidental reports of androgenet...
Minoxidil sulfate is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil. For hair growth, sulfotransferase enzymes expressed in outer root sheath of the hair follicle sulfonate minoxidil. The large intra‐subject variability in follicular sulfotransferase was found to predict minoxidil response and thus ex...
The clinical application of transdermal delivery has been limited to lipophilic drugs with a molecular weight of less than 500 Da. The development of polymeric microneedles enabled the transdermal delivery of larger proteins and drugs. Extensive research has been conducted on the molecular size, solubility, pH, concentration and polarity of transde...
Frontal fibrosing alopecia (FFA) is a slowly progressive cicatricial alopecia. FFA patients typically present with hair loss in the frontal, temporal, or frontotemporal scalp and eyebrows. It can also involve facial and body hair. It has an early inflammatory stage, which slowly progresses to the stage of fibrosis. In this article, we report a case...
The skin is the largest organ in the human body. Methods of childbirth delivery and breastfeeding have significant influence on the composition of the skin microbiome. Common skin diseases related to the follicular unit such as acne, hidradenitis suppurativa (HS), and seborrheic dermatitis are thought to have underlying contributions from alteratio...
Follicular unit extraction (FUE) is a popular hair transplant technique, which involves extraction of follicular grafts from the donor area, usually occipital area of scalp. We have described few cases where non-scarring alopecia patches appeared at donor area similar to that of alopecia areata clinically, after 2-3 weeks of surgery. Even trichosco...
Several studies have established that sulfotransferase enzyme activity in the outer root sheath of plucked hair follicles predicts response to topical minoxidil in the treatment of pattern hair loss. However, the prevalence of this enzyme activity among Indian patients has not been studied. Additionally, no reports in the literature characterize su...
Topical minoxidil is the only US FDA approved OTC drug for the treatment of androgenetic alopecia (AGA). Minoxidil is a pro‐drug converted into its active form, minoxidil sulfate, by the sulfotransferase enzymes in the outer root sheath of hair follicles. Previously, we demonstrated that sulfotransferase activity in hair follicles predicts response...
Minoxidil is the only US FDA-approved topical drug for the treatment of female and male pattern hair loss. Previously, it was demonstrated that topical minoxidil is metabolized to its active metabolite, minoxidil sulfate, by sulfotransferase enzymes located in the outer root sheath of hair follicles. The expression of sulfotransferase in the scalp...
Background
Steatocystoma multiplex is a benign skin disorder originating from the sebaceous and nevoid ducts. Commonly classified under hamartomas, they are distributed over the trunk, neck, axillae, and groin.
Methods
A 28-year-old male patient complained of multiple, asymptomatic skin-colored nodules over the face of 10-year duration. Clinical e...
Background: Cutaneous adverse drug reactions (CADRs) are common, comprising 10%–30% of all reported adverse drug reactions (ADRs) and its incidence in hospitalized patients is 2%–3%. Aims: The aim is to study the different clinical spectrum of CADRs in outpatient and inpatient and to find out the offending drug. Settings and Design: A prospective o...
The Conidiobolus coronatus-related rhinoentomophthoromycosis in immunocompetent and immunocompromised (HIV negative) individuals has been treated successfully with antifungal drugs. However, C. coronatus infections in first-line antiretroviral therapy (ART)-resistant (HIV infected) individuals particularly with rhinoentomophthoromycosis have not be...
How to cite this article
Agarwal SA, Dhurat RS, Agarwal S, Sharma A, Ghate S. Dermoscopy of Rare Pigmented Variant of Bowen's Disease. Int J Dermoscop 2017;1(2):56-59.
Background:
Androgenetic alopecia is a condition with a high prevalence worldwide and affects both males and females. Currently, only 2 approved treatments exist: finasteride (males only) and minoxidil 2 or 5% solution (males and females).
Methods:
We conducted a randomized, open-label, multicenter noninferiority study to determine whether a caf...
Lichen planus pigmentosus (LPP) is a fairly common benign pigmentary disorder in India. This disease was first described in India in 1974. The four main patterns of pigmentation delineated in this disease include diffuse, reticular, blotchy, and perifollicular.
We present a case of the rare reticular variant of LPP with its dermoscopic features.
H...
Alopecia areata (AA) is a common dermatological disease characterized by patchy areas of nonscarring alopecia. Sometimes, differentiating patchy AA from trichotillomania (TTM) can be difficult. We report a case of AA mimicking TTM.
How to cite this article
Shukla D, Vishwanath T, Agrawal S, Dhurat R, Sharma A. A Case of Alopecia Areata Mimicking T...
The efficacy of conventional therapy viz. finasteride and minoxidil in androgenetic alopecia (AGA) that is based on both preventing hair loss and promoting new hair growth, varies between 30% and 60%. This has led to a large number of patients unsatisfied who demand for a better cosmetic coverage over the scalp. Microneedling has recently been repo...
The utility of platelet-rich plasma (PRP) has spanned various fields of dermatology from chronic ulcer management to trichology and aesthetics, due to its role in wound healing. Though PRP is being used over a long time, there is still confusion over proper terminology to define, classify and describe the different variations of platelet concentrat...
Eccrine poroma (EP) is an adnexal tumor that commonly occurs on soles as a soft sessile flesh colored nodule. We report here a case of 54-year-old man who presented with a pedunculated red colored nodule on the right forearm. Histopathological examination was consistent with EP. This presentation of EP on the forearm as a pedunculated nodule is rar...
Solitary mastocytoma, a rare dermatological entity accounts for 10-15% of cutaneous mastocytosis. We report a rare case of solitary mastocytoma presenting at birth, treated successfully with topical tacrolimus. Along with reassurance and strict avoidance of triggering factors, no recurrence was reported within the one year follow-up period.
Perianal pseudoverrucous papules and nodules (PPPN) is a rare entity attributed to chronic irritation. We came across this entity in a case of spina bifida. A 14 year old girl having spina bifida at L3 presented with complaints of multiple asymptomatic whitish lesions on the inner aspect of thighs and labia majora since early childhood. She had inc...
A 65-year-old man presented with multiple asymptomatic papulo-pustules and ulcers over glans penis since last 1 year. The lesions used to resolve spontaneously in a few days with scarring. The clinical features and histopathology were suggestive of papulonecrotic tuberculids of the glans penis.
Dermal papilla (DP) is the site of expression of various hair growth related genes. Various researches have demonstrated the underlying importance of Wnt proteins and wound growth factors in stimulating DP associated stem cells. Microneedling works by stimulation of stem cells and inducing activation of growth factors.
Hundred cases of mild to mode...