Raafia Ali’s research while affiliated with King Edward Medical University and other places

... ARCI has a broad clinical spectrum with variable severity (Vahlquist et al., 2018). The alteration of the skin barrier is mainly manifested by thick, dark brown, generalized scales accentuated on the lower extremities and flexures, accompanied by scaling and erythema in severe cases, resulting in increased transepidermal water loss (Ali et al., 2013;Vahlquist et al., 2018;Gutiérrez-Cerrajero et al., 2023). Oral involvement (Ramar et al., 2014;Nair and Kodhandram, 2016), hypoacusis (Huang et al., 2014), palmoplantar hyperlinearity, diffuse yellowish palmoplantar keratoderma, ectropion, pruritus, alopecia, digital contractures, subungual hyperkeratosis, onychogryphosis, keratosis pilaris, malformation of the nasal cartilage, severe inflammation with a specific immunologic profile and frequent births as collodion babies have also been described (González-Del Carmen et al., 2020;Vahlquist et al., 2018;Süßmuth et al., 2020;Paller, 2019). ...

Reference:

Advances in the treatment of autosomal recessive congenital ichthyosis, a look towards the repositioning of drugs