RS XU’s scientific contributions

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Publications (1)

Telomerase activity in human brain tumors
  • Article

December 1995

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80 Reads

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193 Citations

The Lancet

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RS XU

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Malignant gliomas are invasive into surrounding brain and are refractory to therapy. Telomerase stabilises telomere length and may immortalise cells to allow unlimited proliferation. Our analysis of telomerase activity in 90 human gliomas showed that 19 of 19 oligodendrogliomas and 38 of 51 glioblastoma multiformes have detectable telomerase activity. The absence of telomerase activity in anaplastic astrocytomas (2/20 positive) and in one-quarter (13/51) of the glioblastomas suggests that these tumours follow different pathways of neoplastic progression. Thus we have found that a distinct subgroup of brain tumour consists of transformed yet pre-immortal cells.

Citations (1)

... A mechanism of homologous recombination [18] to maintain TL, known as "alternative lengthening of telomeres" (ALT), was also identified in gliomas. About 20-63% of adult low-grade glioma and 11% of adult GBM use ALT as an additional mechanism for telomere maintenance [19,20]. Dysfunction of the α-thalassemia/mental retardation syndrome X-linked (ATRX)/death-associated protein 6 (DAXX) complex is known to result in ALT along with more widespread genomic destabilization [21][22][23]. ...

Reference:

Alternative lengthening of telomeres is the major telomere maintenance mechanism in astrocytoma with isocitrate dehydrogenase 1 mutation
Telomerase activity in human brain tumors
  • Citing Article

  • December 1995

The Lancet

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RS XU

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