R.J. Krom's research while affiliated with Boston University and other places
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Publications (14)
The increasing incidence of antibiotic-resistant bacterial infections is creating a global public health threat. Since conventional antibiotic drug discovery has failed to keep pace with the rise of resistance, a growing need exists to develop novel antibacterial methodologies. Replication-competent bacteriophages have been utilized in a limited fa...
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Citations
... The crRNA along with gRNA guides the targeted Cas proteins to cut the proto-spacer of the bacterial genome accounts for the death of the bacteria unless it repairs its genome [16]. In addition, the efficiency of the phagemid system can be enhanced by the use of helper plasmids and facilitate the overcoming of the limitations set by the phagemid-based vector (Fig. 2) [40]. Advanced engineering allows the negation of possible backfiring of such models and pushes forward the efficacy of these models. ...
