February 2014
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Diabetes Research and Clinical Practice
Candida esophagitis has become a reality since the advent of endoscopy and diabetes mellitus remains a predisposing factor. The objective was to investigate the characteristics of candida esophagitis in diabetic subjects in Abass Ndao Hospital center (Dakar). This 54-month descriptive cross-sectional study included all diabetics in whom endoscopic investigation revealed candida esophagitis. Among diabetics, there were 116 cases of candida esophagitis (20%). Sex ratio was 2.14 with an average age of 50.8 years. Average glycemia was 3 g/l and mean HbA1c 9.1%. Chronic complications were found in 63.4% of cases with 40% of neuropathy. Co-morbidity consisted mainly of herbal medicine (55.5%), smoking (15.9%), digestive cancer (6.8%), positive HIV (4.5%). Gastrointestinal manifestations were dominated by vomiting (86.3%), epigastric pain (81.8%), hiccups (38.6%) and dysphagia (25%). Anemia was noted in 63.6% of cases. Associated gastrointestinal lesions were hiatus hernia (36.3%), peptic esophagitis (36.3%), gastritis (27.2%) and gastro-duodenal ulcer (20.4%). The outcome was good in 91% of cases put on Fluconazole. Candida esophagitis is favored by chronic hyperglycemia and neuropathy. It should spring to mind in case of refractory gastrointestinal manifestations in the absence of ketosis. (REV.MAGHREB.ENDOCRINOL.DIAB.REPROD., 2013, VOL 18, P 91-96) Key words candida esophagitis, diabetes mellitus, favoring factors