R Samman's research while affiliated with The Princess Alexandra Hospital NHS Trust and other places

Publications (10)

Article
Full-text available
Anejaculation may occur as a result of neurological disease, iatrogenic injury or be drug induced. We report a case of a 66 year old man who presented with anejaculation following an emergency abdominal aortic aneurysm repair. Due to an elevated prostate specific antigen (PSA) level, the patient underwent a prostate biopsy and was diagnosed with a...
Article
Full-text available
Priapism is a pathological condition of penile erection that persists beyond, or is unrelated to, sexual stimulation. Pathologically and clinically, two subtypes are seen-the high flow (non-ischaemic) variety and the low flow (ischaemic) priapism. The low flow type is more dangerous, as these patients are susceptible to greater complications and th...
Article
Full-text available
We present a case of a 59-year-old gentleman with myasthenia gravis and metastatic renal cell carcinoma that resolved on sunitinib. The clear temporal relationship between the patient receiving sunitinib for renal cell carcinoma and the resolution of his myasthenia gravis suggests that the improvement was due either to a paraneoplastic condition re...

Citations

... In this context, there are some examples of currently-marketed pharmaceutical drugs that exhibit simultaneously inhibition of AChE and antitumor properties. For instance, a patient with myasthenia gravis, an autoimmune disease targeting the neuromuscular junction, and with a renal carcinoma, showed [54] an improvement of the neurodegenerative disease upon administration of sunitinib, a clinically-used anticancer agent. Recently it has been demonstrated that such compound exerts a potent inhibition of AChE, attenuating cognitive impairments in a mouse model [55]. ...
... The incidence in the United States is 0.73 per 100,000 males, with bimodal peaks occurring at 5 to 10 years of age in children and 20 to 50 years of age in adults. 1,2 The incidence in children is unknown, although it has been well established that sickle cell anemia (SCA) is the most common cause, whereas other etiologies include leukemia, trauma, medications, and ingestions. ...