R. Sader's research while affiliated with Goethe-Universität Frankfurt am Main and other places

Publications (216)

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Background The present study evaluated the cellular tissue reaction of two equine-derived collagen hemostatic sponges (E-CHS), which differed in thickness after pressing, over 30 days in vivo. The inflammatory response during physiological wound healing in sham-operated animals was used as control group. Material and methods First, the E-CHS was p...
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Zusammenfassung Hintergrund: Entsprechend der Richtlinie Hämotherapie müssen bei Patienten mit planbaren Eingriffen, bei denen periope-rativ eine Transfusion von Erythrozyten-konzentraten (EK) ernsthaft in Betracht kommt, ein gültiger Befund der Blutgrup-penbestimmung und ein Ergebnis des Antikörpersuchtests vorliegen. Die lo-kale eingriffsspezifis...
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Das Plattenepithelkarzinom stellt das sechsthäufigste Malignom des Menschen weltweit dar. Aufgrund der anatomischen Lokalisation im sichtbaren Bereich und seiner engen Lagebeziehung zu wichtigen funktionellen und ästhetischen Strukturen hat dieser bösartige Tumor erhebliche Folgen auf die Lebensqualität der Betroffenen. Daher ist eine hohe Präzisio...
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Purpose The present study evaluated the platelet distribution pattern and growth factor release (VEGF, TGF-β1 and EGF) within three PRF (platelet-rich-fibrin) matrices (PRF, A-PRF and A-PRF+) that were prepared using different relative centrifugation forces (RCF) and centrifugation times. Materials and methods immunohistochemistry was conducted to...
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PRF secretome induces 3D angiogenic activation Immunofluorescence staining of PRF/cell complex after 14 d of cultivation. Representative images of 3D projections using z-stacks obtained with a confocal microscopy using the open source software Image J. Qualitative evaluation of lumen size formation by ECs cultivated with PRF low-RCF.
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Different tissue engineering techniques are used to support rapid vascularisation. A novel technique is the use of platelet-rich fibrin (PRF), an autologous source of growth factors. This study was the first to investigate the influence of PRF matrices, isolated following different centrifugation protocols, on human dermal vascular endothelial cell...
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Mandibular pathologies as oral cancer, septic or aseptic osteonecrosis due to radiation or medication therapy, or severe atrophy cause progressing skeletal compromise with the risk of pathological mandibular fracture (PMF). In a recent clinical study, PMF was reported for 4 out of 44 cases after marginal mandibulectomy related to oral cancer. Motiv...
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Objective To investigate the relationship between tumor-associated macrophages (TAMs), neovascularization, and tumor cell migration in oral squamous cell carcinoma (OSCC) of an African subpopulation. Materials and Methods Twenty OSCC paraffin blocks underwent immunohistochemistry to TAM1 (CCR7), TAM2 (CD206), Twist, E-cadherin, N-cadherin, and CD3...
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Zahlreiche Studien belegen, dass alloplastische Kiefergelenkendoprothesen verglichen mit autologem Kiefergelenkersatz effizienter für die Wiederherstellung der normalen Anatomie und Funktion des Kiefergelenks und der vertikalen Kieferrelation sind. Die Verwendung alloplastischer Materialien für Kiefergelenkendoprothesen vermeidet die Entnahmemorbid...
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Background A remarkable amount of the population is suffering from severe and painful craniomandibular dysfunctions (CMD). During the last decades, computer assisted procedures for diagnosis and therapy planning gained more and more acceptance in the clinical setting. Material and methods In this article, several recent computer assisted methods f...
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Background In numerous animal and human studies, it could be detected that in bone augmentation procedures, material's physicochemical characteristics can influence the cellular inflammatory pattern and therefore the integration in the host tissue. Histological, histomorphometrical, and clinical analyses of the integration of the biomaterial in the...
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This study is the first to show the effect of vismodegib on healthy and tumour cells. Such results are vey important when considering the resection margin after tumour resection. Vismodegib is a small-molecule inhibitor of the Hedgehog signalling pathway. During embryogenesis this pathway plays an important role in the growth and development of tis...
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AnamneseEin 22-jähriger männlicher Patient berichtete, nach einer Party, auf der er Alkohol getrunken habe, in einem heimatnahen Waldstück aufgewacht zu sein. Er erinnerte sich lediglich daran, auf der Feier einen Faustschlag gegen den Kopf bekommen zu haben.Die initiale Behandlung fand in einem kleinen Krankenhaus vor Ort statt, wo der diensthaben...
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Die hohe Anzahl der inserierten Implantate und deren Liegedauer in Kombination mit gesellschaftlichen Aspekten führt zu einer steigenden Inzidenz biofilmassoziierter Entzündungszustände des periimplantären Gewebes. Das Vollbild der Periimplantitis zeichnet sich durch eine Resorption und Destruktion des Hart- und Weichgewebes aus und ähnelt der Paro...
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Computer-assisted methods were used to evaluate different variants of surgically assisted rapid maxillary expansion (SARME) in terms of bone repositioning, new bone formation in the osteotomy gap, and bone quality before and after surgery. Twenty-nine patients (18 male, 11 female) with a mean age of 29 years (16 to 44 years) were included in the st...
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Magnetic resonance imaging (MRI) has been approved as an appropriate radiological modality for temporomandibular joint (TMJ) diagnosis, whereas the results of international multicenter studies impressively show the limitations of static three-dimensional MRI. The state of the art for dynamic imaging of the TMJ in real-time are TrueFISP sequences in...
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Tightly controlled wound inflammation is a central determinant of skin flap survival in healthy mice. This study investigated inflammatory response patterns in caudally pedicled skin flaps in diabetic mice during severely impaired conditions of necrotic skin flap tissue loss. Skin flap biopsies were analysed by RNase protection assay, quantitative...
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This technical note describes a new surgical technique for a palatal approach to the maxillary sinus for a vertical augmentation prior to dental implant placement. In 12 fully or partially edentulous patients (seven women, five men), 16 palatal sinus elevations were performed. After elevation of palatal full-thickness flap a rectangular access wind...
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Treatment of palato-nasal fistula following primary palatoplasty in patients with nonsyndromic cleft palate is often complicated by recurrence. The authors have tested the feasibility of a surgical technique adding a resorbable collagen membrane at the bony edge of the fistula and report the outcome in the first 14 patients in an open, non-comparat...
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In this study, four methods of postoperative speech evaluation are compared for 19 persons with oral cancers who have undergone oral surgery and/or radiotherapy. The Munich Intelligibility Profile was used for intelligibility testing and semiquantitative scoring by novice listeners. Expert ratings were done on the Therapy Outcome Measure (TOM) Phon...
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Severe panfacial trauma require broad reconstructive procedures. As in the case presented, a primary reconstruction with ideal aesthetic outcome cannot be reached in every case. If not, these cases often require further reconstructive procedures. What this can be and how long this could take, this article intends to show. This case report presents...
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Outpatient surgery in the oral cavity requires a thorough knowledge of indication and application of many medications that are used to control swelling, pain, infection or bleeding. In an overview presentation, the effectiveness of the local anesthetics mainly used is presented. Particular emphasis is put on indications and special properties such...
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The purpose of this retrospective study was to evaluate the surgical performance, clinical usability and outcome of a new variable square pulsed (VSP) Er:YAG laser for bone cutting in oral and maxillofacial surgery. In 40 patients an Er:YAG laser with pulse energy of 1,000 mJ, pulse duration of 300 mus and a frequency of 12 Hz was used for differen...
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Based on so called “quasi-continuous MRI” of a highly trained volunteer, 4D-visualization of a moving human foot due to ankle joint flexion is provided. In particular, visualization of the pedestrial superficial soft tissue as well as of the skeletal tissue is given. By our approach, we inter alia contribute to various kind of simulation of the low...
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Within a clinical study, 30 pre- and post-operative CT-data sets were acquired directly before and 6 – 11 weeks after surgical maxillary expansion. The pre- operative data were rigidly registered on the post-operative ones. Subsequent 3D-reconstruction showed the skeletal changes due to the surgery. By an approach developed in the group, new bone f...
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Piezoosteotomy was assessed as alternative osteotomy method in orthognathic surgery regarding handling, time requirement, nerve and vessel impairment. In this comparative clinical experience, 90 patient's orthognathic surgery procedures were performed in typical distribution prospectively by piezoosteotomy: 34 (38%) monosegment, 47 (52%) segmented...
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In neoplastic processes in the orbital area, a not significant part of these new entities is caused by tumours of the peripheral nervous system. Due to a clinically similar behaviour and radiological features also being similar, these tumours sometimes cause differential diagnostic difficulties. Our experience with these tumours shows that they do...
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Bei neoplastischen Prozessen im Bereich der Orbita wird ein nicht unerheblicher Teil dieser Neubildungen durch Tumoren des peripheren Nervensystems verursacht. Aufgrund eines klinisch ähnlichen Verhaltens und sich gleichender radiologischer Merkmale verursachen diese Tumoren manchmal differenzialdiagnostische Schwierigkeiten. Unsere Erfahrung mit d...
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Surgical reconstruction of bony defects in the oral cavity can often be challenging since thin and fragile bony structures are especially prone to fracture cased by bulky cutting tips or the application of significant pressure by conventional mechanical instruments. The risk of accidental damage to adjacent soft tissue structures, such as nerves, b...
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Individual bone quality depends on genetic, biological, and mechanical influencing factors, where the latter is accessible via Finite Element Simulation. This work is part of an interdisciplinary research project with the purpose of stepwise refinement towards anatomical reality. This approach opened the door for many interrelated applications such...
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To evaluate the computed tomography (CT) and magnetic resonance imaging (MRI) findings of biphosphonate therapy-associated changes of the mandible and maxilla. Thirty-two patients with a clinical history of pain, purulent discharge, and swelling in the mandible or maxilla as well as non-healing dental extraction were examined. All patients had rece...
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Despite remarkable progress within the last decade, the treatment of mandibular fractures is still a highly discussed topic in oral and cranio-maxillofacial surgery. The possible traumatologic scenarios are characterized by high variability. A current project is focused on "resimulation" of traumatologic cases given by clinical radiographs by means...
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Purpose: Surgical reconstruction of bony defects in the oral cavity can often be challenging since thin and fragile bony structures are especially prone to fracture cased by bulky cutting tips or the application of significant pressure by conventional mechanical instruments. The risk of accidental damage to adjacent soft tissue structures, such as...
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Within the biomechanics of bony organs, individual tissue anisotropy and inhomogeneity are intensively discussed subjects. This paper is dedicated to the impact of a fully anisotropic and inhomogoneous material description on the structural behaviour of an elderly partially edentulous human mandible. Radial, axial, and circumferential trajectories...
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This article is dedicated to the evaluation of traumatologic standard situations of a human mandible by means of finite element simulation for the sake of improved therapy and surgery planning, as well as forensic examination. In a first step, an already existing parametric platform for flexible calculation of the stress/strain profiles due to huma...
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Children with cleft lip and/or cleft palate (CLP) often have additional congenital malformations. The reported incidences are variable and presumed underlying mechanisms are rarely discussed. In this study, 245 CLP patients of a geographically defined population were retrospectively reviewed for additional major malformations and minor anomalies. M...