R. Raja Reddy’s scientific contributions

The objective of this research work is to formulate an immediate release tablet of "Atazanavir" for rapid action, by using suitable super-disintegrants like Crospovidone, Croscarmellose sodium, Sodium starch glycolate and Carmellose calcium at different concentrations ranging from 2-10 percent by direct compression method. The prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and In-vitro dissolution profile. The spectral analysis revealed that there was no interaction between the drug & excipients. The drug release from immediate release tablets increased with increasing concentration of super-disintegrants and was found to be highest with formulation (F18) containing Crospovidone with 10% concentration.