January 1930
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136 Reads
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10,527 Citations
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January 1930
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136 Reads
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10,527 Citations
... The adaptive maintenance of multiple alleles of a single gene has been posited for nearly a century (Fisher, 1930;Ford et al., 1940;Dobzhansky, 1950;Cain and Sheppard, 1954;Dobzhansky, 1970), and evidence for its pervasiveness continues to grow (Hedrick and Thomson, 1983;Subramaniam and Rausher, 2000;Koskella and Lively, 2009;Leffler et al., 2013;Delph and Kelly, 2014;Lee et al., 2021). However, there are relatively few cases where we understand the adaptive benefits of both alleles (sickle cell anemia and malaria resistance being the best studied example [Piel et al., 2010]). ...
January 1930