Qixia Xu's research while affiliated with Chinese Academy of Sciences and other places

... High expression of EREG was associated with tumor stage, metastasis and survival in human cancer patients. DNA-damaging agents (DDAs), such as bleomycin, mitoxantrone, and doxorubicin, induced the expression of EREG in stromal cells (115). Stromal EREG The role of E3 ubiquitin ligases and DUBs in regulation of PD-1/PD-L1 in cancer. ...

... Age-related diseases and their corresponding social burden are increasing. Ageassociated immune senescent modifications might lead to a decrease in the immune system, chronic inflammation, in addition to weakness, chronic disease, and loss of function among old people [247]. Translating approaches that target senescent cells into clinical practice could have a major impact on curing a range of diseases that occur with age and perhaps change our perspective of ageing. ...

... Notably, some Jumonji KDMs were increased in response to CP treatment ( Fig S1A). This is consistent with previous studies showing expression of different Jumonji KDMs induced in response to CP. 16,17 CPR cells expressed elevated levels of multiple Jumonji KDMs compared to parental controls, both basally and in response to CP. Some of these KDMs (KDM3A, KDM4B, KDM5A, and KDM6A) were commonly overexpressed in all 3 CPR cell populations (names in red in Fig. S1A). ...

... There are many V. vinifera cultivars and the cold hardiness of different varieties varies, with few V. vinifera varieties are suitable for cultivation in any specific country or region (Zhan and Li, 2010;Wang et al., 2021b). Most research on V. vinifera has focused on cultivation management (Ju et al., 2019;Yue et al., 2020;Wang et al., 2021a;Yue et al., 2021), fruit quality regulation (Bohan et al., 2020;Yang N. et al., 2021), wine-making characteristics Wei et al., 2022), grape and wine nutrition (Cheng et al., 2021;Xu et al., 2021;Yang C. et al., 2021), and hardiness improvement Wan et al., 2021;Wang et al., 2021c;Wang et al., 2022), but there has been little comprehensive work to determine the most appropriate methods for the evaluation of cold hardiness in V. vinifera. Most methods used thus far to investigate cold hardiness are relatively simple methods that are not targeted, so the results obtained using different cold hardiness evaluation methods will be different (He, 2015). ...

... At the transcriptional level, several transcription factors (NF-κB, C/EBP-β) and upstream regulators (p38 MAPK, GATA4, p53, and ATM) have been described to either positively or negatively regulate SASP gene expression [16,[19][20][21][22][23][24][25]. The SASP is also regulated at both the epigenetic [26][27][28][29][30][31][32] and translational level [17,33]. Recent publications suggest that the initiation of AGING SASP gene transcription during OIS is likely due to loss of lamin B1 (LMNB1) and nuclear integrity [34,35], leading to the accumulation of cytoplasmic chromatin fragments (CCFs) [36,37]. ...

... Recent work along with our transcriptome profiles showed that TGF-β signaling is dysregulated in senescent MSCs [16,17]. Studies have also demonstrated that senescent cell-secreted vesicles can enhance aggressive phenotypes during cell-cell interaction via TGF-β signaling pathways [18][19][20]. Therefore, we further examined significantly altered genes for each of the related transcriptome pathways ( Figure 1C-1F). ...

... However, their role in the development of tumours has also been shown [75]. Recent studies revealed that amphiregulin is produced by senescent cells and its presence is a negative background provoking expression of programmed cell death 1 ligand (PD-L1) and cancer development [76,77], (Figure 2). This role of T regs associated with age-dependent carcinogenesis is being actively investigated. ...

... The size distribution was analyzed using a 2200 TapeStation Instrument (Agilent Technologies). Based on DNA concentration and average fragment size, libraries were pooled and denatured as previously described [71]. The libraries were sequenced on a HiSeq 2500 system using 100-bp paired-end sequencing (Illumina) to generate approximately 50-80 million reads per sample. ...

... Depletion of ZSCAN4 was found to have inhibitory effect on tumor growth in HNSCC [30]. Moreover, Zhang et al. found that ZSCAN4 expression is increased in DNA-damaged stromal cells that leads to a senescence-associated secretory phenotype (SASP), mediated by the ATM/TRAF6/TAK1/p65 signaling axis [31]. They also disclosed that targeting TAK1 in vivo increases chemosensitization and promotes tumor regression. ...

... EpCAM has been detected in exosomes isolated from serum of patients with ovarian cancer, which confirmed the presence of diagnostic miRNAs in exosomes (50). A further study showed that serum exosomes from patients with ovarian cancer contained higher levels of mRNA and miRNA than those from healthy people (51), which provided a basis for tumor-derived exosomes to participate in the transport of genetic material between cells. This also demonstrates that diagnostic miRNAs in serum exosomes of patients with ovarian cancer can be used for the diagnosis of ovarian cancer (52,53). ...