Qiuqin Tang's research while affiliated with Hubei Maternal and Child Health Hospital and other places

Publications (49)

Article
Macrosomia is a common perinatal complication, with a series of adverse effects on newborns and pregnant women. However, the effects of long non‑coding RNAs (lncRNAs) on non‑diabetic fetal macrosomia (NDFMS) remain unclear. The aim of the present study was to investigate whether aberrant lncRNA expression in the placenta is involved in the pathogen...
Article
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Some studies have examined the association between air pollution and semen quality. While it is less of evidence on the sperm quality after long-term air pollution exposure, especially the co-exposure of different air pollution components. Additionally, the role of DNA methylation in it hasn't been confirmed. This study aimed to investigate whether...
Article
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Background Several studies have suggested adverse effects of particulate matter (PM) exposure on male reproductive health; few have investigated the association between PM exposure and semen quality in a large population of fertile men. Methods We evaluated 14 parameters of semen quality in 1554 fertile men in Nanjing from 2014 to 2016. Individual...
Preprint
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Background: WeChat and micro-courses have become important tools for improving medical education. However, most research just focused on one of them, and investigations about “WeChat + micro-courses” teaching mode were still lacking. Purpose: The aim of this study was to investigate medical students’ use of WeChat and micro-courses and to analyze t...
Preprint
BACKGROUND WeChat and micro-courses have become important tools for improving medical education. However, most research just focused on one of them, and investigations about “WeChat + micro-courses” teaching mode were still lacking. OBJECTIVE The aim of this study was to investigate the use of WeChat and micro-courses in different majors of medica...
Chapter
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Oxytocin, an important neuropeptide, exerts a wide influence on the central nervous system and the peripheral tissues. In the central nervous system, the oxytocin gene expression is mainly shown to be present in neurons in the hypothalamic paraventricular and supraoptic nuclei. Oxytocin gene also transcribes in the peripheral tissues such as uterus...
Article
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Preeclampsia (PE) is commonly considered as a placental disorder in pregnancy. Until now, the etiology and pathological mechanism of PE have remained ambiguous. Although PE can lead to a variety of maternal and infant complications, there are still no effective treatments. This study aimed to explore the correlation between the novel polypeptide CO...
Article
During the COVID-19 epidemic, online teaching was widely used at Nanjing Medical University. Based on the practice, student evaluation surveys were used as the main assessment to analyze the effect of online teaching. Eventually, 826 undergraduates at Nanjing Medical University participated in the questionnaire survey. This study described the pres...
Chapter
Epidemiological and animal experimental studies have shown that early imbalance of intrauterine nutrition leads to permanent changes in body physiology and metabolism, which may later result in the development of adult chronic diseases such as obesity, type II diabetes, high blood pressure, and coronary disease in offspring. This process takes plac...
Article
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Background: Numerous health effects of smoking are well-known; associations with semen quality are uncertain. Most previous studies did not adjust for potential confounders and had limited information on age at smoking initiation or smoking cessation. Methods: We investigated 1,631 healthy fertile men in the Nanjing Medical University Longitudin...
Article
Previous studies have suggested that altered miRNA expression in the placenta is associated with preeclampsia. The aim of this study was to investigate the expression of miR-424 in placental samples of severe preeclampsia (sPE) and uncomplicated pregnancy patients. miRNA was isolated from placentas obtained from 30 sPE patients and 30 healthy women...
Article
Polybrominated Diphenyl Ethers (PBDEs) have been extensively applied as flame retardants in different polymeric materials since the 1970s, which have become a group of long-lasting environmental pollutants. They have been reported from previous studies to accumulate and then disrupt the endocrine system in humans. However, the mechanisms are still...
Article
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Background: Several studies have reported microRNAs (miRNAs) could regulate the placental development, though the role and mechanism of miRNAs in the development of non-diabetic macrosomia (NDFMS) remains unclear. Methods: To identify the aberrantly expressed key miRNAs in placenta of NDFMS, we employed a strategy consisting of initial screening wi...
Article
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Background: Male infertility is a complex disease caused by a combination of genetic, environmental, and lifestyle factors. Abnormal epigenetic programming has been proposed as a possible mechanism compromising male fertility. Recent studies suggest that aberrant imprinting in spermatozoa in a subset of infertile men is a risk factor for congenita...
Article
Study question: What is the role of insulin-like growth factor 2 (IGF2)-derived miR-483-3p in macrosomia? Summary answer: IGF2-derived intronic miR-483-3p is overexpressed in macrosomia placentas, and miR-483-3p prompts HTR-8/SVneo extravillous trophoblast cell line proliferation through down-regulation of its target RB1 inducible coiled-coil 1...
Preprint
Several studies have shown microRNAs (miRNAs) could regulate the placental development, yet the role and mechanism of miRNAs in the development of non-diabetic macrosomia (NDFMS) remains unclear. The key miRNA that abnormal expressed in NDFMS placentas was screened out by miRNA microarray and verified using qRT-PCR in 91 subjects. The effects of th...
Article
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The purpose of this study was to investigate the association between male infertility and single-nucleotide polymorphisms (SNPs) of DNA methyltransferases (DNMT) genes (DNMT3B: rs2424909, DNMT1: rs4804490, DNMT3A: rs1550117 and DNMT3L: rs7354779). Eight hundred and thirty three idiopathic infertile males and four hundred and ten fertile controls fr...
Article
Background: Recent studies have identified that exposure to particulate matter during pregnancy could result in adverse birth outcomes, but the effects of exposure at trimester-specific intervals are inconsistent. Objective: Our primary goal was to investigate whether particulate matter exposure during pregnancy could affect birth weight and ges...
Article
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We used a gas chromatography-mass spectrometry (GC-MS) based metabolomics approach to obtain the metabolic profiling of unexplained male infertility (UMI), and identified seminal plasma biomarkers associated with UMI by a two-stage population study. A robust OPLS-DA model based on these identified metabolites was able to distinguish 82% of the UMI...
Article
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There is increasing concern that early-life exposure to endocrine disruptors affects male offspring reproduction. However, whether di-n-butyl phthalate (DBP), a widely used endocrine disruptor, has transgenerational effects and, if so, the exact underlying molecular mechanisms involved remain unknown. In our study, 5 of time-mated pregnant SD rats...
Article
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Genistein (GEN) is one of the isoflavones that has effect on male reproduction. However, the underlying mechanism remains unknown. miRNAs are a type of small non-coding RNAs that play important roles in spermatogenesis. We measured the GEN levels and miR-17-92 cluster expression in infertile subjects and found that miR-17-92 might be involved in GE...
Article
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The development of male infertility increased rapidly worldwide, which coinciding with the epidemic of obesity. However, the impact of weight abnormalities on sperm quality is still contestable. To assess the correlation between BMI and sperm parameters, we searched relevant articles in PubMed, Embase, Web of science, and Wanfang database published...
Article
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Gold nanorods (GNRs) are among the most commonly used nanomaterials. However, thus far, little is known about their harmful effects on male reproduction. Studies from our laboratory have demonstrated that GNRs could decrease glycine synthesis, membrane permeability, mitochondrial membrane potential and disrupt blood-testis barrier factors in TM-4 S...
Article
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The association between polymorphism of androgen receptor gene CAG (AR-CAG) and male infertility in several studies was controversial. Based on studies on association between AR-CAG repeat length and male infertility in recent years, an updated meta-analysis is needed. We aimed to evaluate the association between AR-CAG repeat length and male infer...
Article
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MicroRNA plays an important role in spermatogenesis. Whether pre-miRNAs polymorphisms are associated with idiopathic male infertility remains obscure. In this study, 1378 idiopathic infertile males and 486 fertile controls were included between 2006 and 2014. Genotype of three polymorphisms (hsa-mir-146a rs2910164, hsa-mir-196a-2 rs11614913, and hs...
Article
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Macrosomia is one of the most common perinatal complications of pregnancy and has life-long health implications for the infant. microRNAs (miRNAs) have been identified to regulate placental development, yet the role of miRNAs in macrosomia remains poorly understood. Here we investigated the role of miR-17-92 cluster in macrosomia. The expression le...
Article
Full-text available
Objectives: To evaluate whether single nucleotide polymorphisms of HSD11B1 (rs846908) and H6PD (rs6688832 and rs17368528) are associated with polycystic ovary syndrome (PCOS) in Chinese population. Materials and methods: A case-control study was implemented to investigate the association between HSD11B1 and H6PD polymorphisms and PCOS. Patients...
Article
Objective: To assess whether single nucleotide polymorphisms of HSD17B5 (AKR1C3) (rs1937845 and rs12529) and HSD17B6 (rs898611) are associated with polycystic ovary syndrome (PCOS) in a Chinese population. Design: A case-control study was conducted to investigate the relation between HSD17B5 and HSD17B6 polymorphisms and PCOS. Methods: In this...
Article
Endometriosis is a chronic disease that affects roughly 5-15 % of women of reproductive age. The pathophysiology of the disease occurrence and progression is unclear. MicroRNAs (miRNAs) are short, non-coding RNAs that have important regulatory function. It has been postulated that abnormal expression of miRNA is associated with ovarian endometriosi...
Article
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Several studies have investigated the association between polymorphisms in the Deleted in AZoospermia-Like (DAZL) gene and male infertility risk, but with inconsistent results. We aimed to derive a more precise estimation of the relationship, therefore a meta-analysis was performed. A total of 13 case-control studies, including 2556 cases and 1997...
Article
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Several molecular epidemiological studies have been conducted to examine the association between glutathione S-transferase mu-1 (GSTM1) and glutathione S-transferase theta-1 (GSTT1) null polymorphisms and childhood acute leukemia; however, the conclusions remain controversial. We performed an extensive meta-analysis on 26 published case-control stu...
Article
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Published data on the association between the GST genes polymorphisms and male infertility risk are inconclusive. We investigated GST genes polymorphisms in a large sample size case-control study, and conducted a literature-based meta-analysis of 6934 individuals. Our case-control study showed the GSTM1 null genotype was significantly associated wi...
Data
The correlation between expression level of E2F3 (A), PLAG1 (B), TGFβ2 (C) and miR-141 expression levels in placentas. The correlation was calculated by Spearman correlation analysis. (TIF)
Article
Full-text available
Background Fetal growth restriction (FGR) is an important but poorly understood condition of pregnancy, which results in significant fetal, neonatal and long-term morbidity and mortality. Novel research has suggested that altered miRNA expression in the plasma and placenta is associated with adverse pregnancy. We hypothesized that aberrant expressi...
Data
Pathways probably regulated by miR-141 in FGR. (DOC)
Data
The primary and secondary antibodies of miR-141 target genes and GAPDH were used in Western blot. (DOC)

Citations

... The respondents' remarks about impact of online education on their individual studying revealed their problems with adapting to a more active approach to self-directed learning than they had previously be used to. The participants in other studies also perceived their autonomous learning (without regular guidance from teachers) as ineffective and complained of lack of self-discipline [24,28,29]. These findings hint at the need for curriculum to become more studentcentered and with a greater focus on teaching study skills at the outset. ...
... Studies have shown the impact of various external factors such as geographic variations, time of birth, malnutrition, infectious diseases, and gynecological complications on schizophrenia [59]. The divergence of developmental trajectories within psychopathologies is believed to be associated with transgenerational inheritance [60]. Similarly, the intergenerational phenotypic transfer is also linked with psychotic disorders, indicating a direct manifestation of hypertension from the parental generation [61]. ...
... Previous studies have reported that smoking has adverse effects on sperm parameters, such as lower sperm progressive motility (Ou et al., 2020), lower sperm volume (Tang et al., 2019), lower sperm count and abnormal morphology of sperm (Rehman et al., 2019). Our study found that former smokers appeared to have higher sperm volume while current smokers seem to have lower sperm volume, compared to non-smokers. ...
... In fetal porcine Leydig cells, several BFRs reduced testosterone synthesis by inhibiting specific enzymes in the steroidogenesis pathway (Mankidy et al., 2014). Using the mouse LTC-1 Leydig cells, Han et al. (2019) demonstrated an inhibition of steroid production after exposure to deca-brominated diphenyl ether (BDE-209). Treatment of Long-Evans rat dams with a single dose of BDE-99 on gestation day 6 reduced AGD and decreased circulating sex steroids in male offspring (Lilienthal et al., 2006). ...
... In this study, through circRNA/miRNA interactions analysis, we found that most of the exosomal circRNAs had miRNA binding sites, and some miRNAs were associated with PE. For example, miR-17-3p, miR-197, miR-424, miR-431 and miR-483 were reported to be aberrantly expressed in preeclamptic placenta [36][37][38][39][40]. miR-17-3p and miR-424-5p were matched with circ_0077260, which was verified to upregulated in the umbilical cord blood exosomes of PE patients; miR-197-5p and miR-431-5p potentially binds to downregulated circ_0076206; whereas miR-424-5p and miR-483-3p potentially matched with upregulated circ_0090100. ...
... MiR-141-3p has been reported to be upregulated in various malignancies, such as colorectal cancer, lung cancer, prostate cancer, and cervical cancer (7). Moreover, miR-141-3p overexpression increased cell proliferation, while miR-141-3p knockdown suppressed the proliferation of various cell types (21)(22)(23)(24). In addition, this study showed that miR-141-3p stimulated the gene expressions of PCNA and CCND1, which are target genes of YAP and related to cell cycle progression. ...
... Numerous studies in human cohorts have identified specific DNA methylation profiles associated with altered semen parameters [23][24][25], embryo quality after in vitro fertilization [26], and infertility or subfertility in normozoospermic patients [27,28]. However, these studies did not reach a consensus regarding a DNA methylation signature for subfertility or infertility [29], with the exception of specific alterations targeting imprinting genes [30], although this view has also been disputed recently [31]. ...
... Through combined data from several bioinformatics tools predicting the targets of miR-483−3p, this study focused on IGF-1. Intriguingly, miR-483−3p levels were positively associated with the expression levels of its host gene IGF2, potentially functioning synergistically with IGF-2 [27,28]. We found that miR-483−3p directly interacted with the 3′UTR of IGF-1 in RA FLSs via the luciferase assay. ...
... Chemical substances found in the environment (such as heavy metals and dioxins) in food (such as agro-pharmaceuticals or insecticides), as well as unhealthy life styles or electromagnetic pollution are the main cause of alterations of semen parameters [7,8]. The well-known mechanisms whereby chemical and physical environmental factors, whether combined or not, interfere with reproductive function are: induction of oxidative stress, hormonal imbalance, genetic and epigenetic alterations [9,10]. ...
... Particulate matter (PM) causes health effects being linked to allergy, cardiovascular and respiratory symptoms (Nozza et al., 2021 and references therein), low neonatal birth weight (Han et al., 2018) and life-expectancy reduction (Pope et al., 2009). Furthermore, PM damages the environment in many ways: it interacts with clouds affecting climate (IPCC 2013), decreases atmospheric visibility (Bӓumer et al., 2008;Vecchi et al., 2018); can interfere with the Earth's radiation budget (Fountoukis et al., 2020); increases ecosystems acidification (Narita et al., 2019) and threatens cultural heritage (Nava et al., 2010). ...