Qingxiao Li’s research while affiliated with University of Hawaiʻi at Mānoa and other places

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Publications (1)


The typical chromatograms of disulfoton and its five metabolites (0.02 mg/L) in ACN: (1) demeton-S-sulfone, (2) demeton-S-sulfoxide, (3) disulfoton-sulfone, (4) demeton-S, (5) disulfoton-sulfoxide, and (6) disulfoton
Extraction recoveries of disulfoton in different agro-product matrices purified with different clean-up sorbents
Matrix effects for disulfoton and its five metabolites in different agro-product matrices
Development and Validation for Simultaneous Determination of Disulfoton and Its Five Metabolites in Seven Agro-Products Using Liquid Chromatography-Tandem Mass Spectrometry Combined with QuEChERS Extraction Method
  • Article
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June 2022

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66 Reads

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1 Citation

Chromatographia

Hui Li

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Lingyi Pan

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Chunsheng Yu

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Qingxiao Li

Disulfoton is highly toxic insecticide and acaricide. Food safety requires analysis of disulfoton and its five metabolites (disulfoton-sulfoxide, disulfoton-sulfone, demeton-S, demeton-S-sulfoxide, and demeton-S-sulfone). However, simultaneous determination of disulfoton and its metabolites in agro-products was not established, and the limits of quantification (LOQs) of reported methods could hardly meet the requirement of maximum residue limits (MRLs) set by some countries or organizations. In the present study, disulfoton and its five metabolites in seven agro-products (maize, oat, rice, pea, asparagus, milk and chicken) were extracted according to a modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) procedure and simultaneously determined with a liquid chromatograph tandem-mass spectrometer. The method was accurate and reliable after optimization of several key parameters (chromatographic columns, mobile phase, and clean-up sorbents). The sensitivity of the proposed method was greatly improved through the concentration process. Matrix effects for six analytes in different matrices were evaluated, and matrix-matched calibration standards were used to compensate these matrix enhancement or suppression effects. Under optimal conditions, the developed method showed satisfactory linearity with coefficients of determination (R²) > 0.9919. The limits of detection (LODs) for all target analytes in different agro-products ranged from 0.01 to 1.68 µg/kg, while the LOQs were 5 µg/kg for disulfoton, and 1 µg/kg for its each metabolite. At three fortification levels, the mean recoveries were in the range of 71.3–114.4% with relative standard deviations (RSDs) < 16%. Analysis of 70 market samples showed a trace amount of disulfoton and/or its metabolites in 10% samples. In conclusion, the developed method exhibited both high sensitivity and accuracy, and is suitable and practical for the simultaneous determination of trace levels of disulfoton and its five metabolites in agro-products of plant and animal origin.

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Citations (1)


... Disulfoton has been extensively used across a wide range of crops to manage sap-feeding insects, including aphids, mites, and thrips [76]. Its mode of action involves inhibiting the enzyme acetylcholinesterase (AChE) [77,79], which leads to the accumulation of acetylcholine in nerve endings in both the peripheral and central nervous systems. Consequently, disulfoton poses a high level of toxicity to humans [80][81][82]. ...

Reference:

Long-Chain Molecules with Agro-Bioactivities and Their Applications
Development and Validation for Simultaneous Determination of Disulfoton and Its Five Metabolites in Seven Agro-Products Using Liquid Chromatography-Tandem Mass Spectrometry Combined with QuEChERS Extraction Method

Chromatographia