Qin Qi's research while affiliated with Shanghai University of Traditional Chinese Medicine and other places

Publications (23)

Article
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Fibrosis can occur in many organs, and severe cases leading to organ failure and death. No specific treatment for fibrosis so far. In recent years, microRNA-34a (miR-34a) has been found to play a role in fibrotic diseases. MiR-34a is involved in the apoptosis, autophagy and cellular senescence, also regulates TGF-β1/Smad signal pathway, and negativ...
Article
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Sirtuin 3 (SIRT3), the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, acts as a metabolic modulator mainly located in mitochondria via regulating the process of the relevant biochemical processes by targeting crucial mediators. Recently, owing to its dual role in cancer, SIRT3 has attracted extensive attention. Cancer cells have di...
Article
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Nuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes. Bile acids (BAs) can be used as effector molecules to regulate physiological processes in the gut, and NRs are important receptors for bile acid signaling. Relevant studies have shown that NRs are closely related to the occurrence of...
Article
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Background: The pathogenesis of ulcerative colitis (UC) is closely related to the gut microbiota. Moxibustion has been used to improve the inflammation and gastrointestinal dysfunctions in gastrointestinal disorders such as UC. In this study, we investigated whether moxibustion could improve the gut microbial dysbiosis induced by dextran sulphate...
Article
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Acupuncture and moxibustion have definite clinical effects on treating ulcerative colitis (UC), but their mechanism is still unclear. To investigate the molecular mechanisms, we applied herb-partitioned moxibustion or electroacupuncture at the Tianshu (ST25) points on UC rats and used RNA sequencing to identify molecular consequences. Male Sprague...
Article
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Objective: To evaluate the effects of electroacupuncture and moxibustion on brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase receptor B (TrkB) protein and mRNA expressions in the colon and dorsal root ganglia of IBS rats with visceral hypersensitivity and to explore their underlying therapeutic mechanisms. Method: Forty...
Preprint
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Background: Recent studies have shown that the pathogenesis of ulcerative colitis (UC) is closely related to the gut microbiota. Moxibustion, a common treatment in traditional Chinese medicine, is the burning of the herb moxa over acupuncture points. Moxibustion has been used to improve the inflammation and gastrointestinal dysfunctions in gastroin...
Article
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Objective: To identify differentially expressed proteins (DEPs) in sera of patients with chronic atrophic gastritis (CAG) using isobaric tags for relative and absolute quantitation (iTRAQ) and to explore acupuncture's mechanism in CAG. Methods: Peripheral sera from 8 healthy volunteers (HC), 8 chronic nonatrophic gastritis (NAG) patients, 8 CAG...
Article
Objective: To evaluate the efficacy of herb-partitioned moxibustion (HPM) at Qihai (CV6), Tianshu (ST25) and Shangjuxu (ST37) acupoints in relieving symptoms and the immune regulation of HPM on the toll-like receptors 4 (TLR4) signaling pathway in ulcerative colitis (UC) patients. Methods: A randomized, single-blind study was conducted 63 patien...
Article
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Cofilin is an actin-binding protein that regulates filament dynamics and depolymerization. The over-expression of cofilin is observed in various cancers, cofilin promotes cancer metastasis by regulating cytoskeletal reorganization, lamellipodium formation and epithelial-to-mesenchymal transition. Clinical treatment of cancer regarding cofilin has b...
Preprint
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The role of RNA m ⁵ C (5-methylcytosine) and RNA m ⁵ C methyltransferases (RCMTs, including NSUN1, NSUN2, NSUN3, NSUN4, NSUN5, NSUN6, NSUN7 and TRDMT1) in human cancers remains largely unknown. In this study, GEPIA2 was used to compare the expression of RCMTs in human cancers and that in associated normal tissues, and to analyze the prognosis value...
Article
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Background: Fatigue is one of the primary symptoms in lung cancer, with a prevalence of 88.0% in survivors of cancer, and an even higher prevalence post resection surgery. Effective fatigue control after lung cancer surgery is important for patient recovery and quality of life. Some studies have shown that acupuncture might be effective in treatin...
Preprint
Background Fatigue is one of the primary symptoms of lung cancer patients, with a prevalence of 88.0% in cancer survivors, and even higher post resection surgery. Effective fatigue control after lung cancer surgery is important for patient recovery and quality of life. Some studies have shown that acupuncture might be effective in treating cancer-r...
Preprint
Background Fatigue is one of the primary symptoms of lung cancer patients, with a prevalence of 88.0% in cancer survivors, and even higher post resection surgery. Effective fatigue control after lung cancer surgery is important for patient recovery and quality of life. Some studies have shown that acupuncture might be effective in treating cancer-r...
Article
Full-text available
Background: Moxibustion treatment has been found to ameliorate clinical symptoms including abdominal pain, diarrhoea and constipation in patients with irritable bowel syndrome (IBS). Herein we investigated the mechanisms underlying the use of moxibustion in a rat model of IBS. Methods: In our study, an IBS model was established in rats by colore...
Article
Full-text available
Objective: To investigate the immune regulation mechanism of herb-partitioned moxibustion in rats with Crohn's disease (CD) focusing on autophagy. Methods: Rats were randomly divided into normal (N) group, CD model (M) group, CD model with herb-partitioned moxibustion (MM) group, normal with herb-partitioned moxibustion (NM) group, CD model with...
Article
Full-text available
Background The pathogenesis of irritable bowel syndrome (IBS) is closely related to intestinal dysbacteriosis and can be controlled by moxibustion treatment. However, the mechanism underlying the therapeutic value of moxibustion in IBS treatment remains unknown. Methods An IBS rat model was established by colorectal distention (CRD) stimulus and m...

Citations

... Apart from these studies, little is known regarding the factors that influence Acinetobacter colonization and little data exists on the effects of A. calcoaceticus. The importance of Acinetobacter in the gut is highlighted by the fact that Acinetobacter species are elevated in certain disease states including ulcerative colitis, a subset of inflammatory bowel disease (IBD) (Gophna et al., 2006;Lucke et al., 2006;Leung et al., 2014;Kevans et al., 2015;Tang et al., 2015;Sjoberg et al., 2017;Sekido et al., 2020;He et al., 2021;Qi et al., 2022). In this study, we sought to examine the ability of A. calcoaceticus strains to survive environmental stressors found in the gut, interact with other gut microbes and utilize dietary components. ...
... The analgesic effect of EA on visceral hypersensitivity has been extensively demonstrated (40)(41)(42)(43)(44), and the results of our study are consistent with this. EA reduced AWR scores and increased PWT, indicating that EA attenuated the visceral sensitization and peripheral mechanical hyperalgesia of PI-IBS. ...
... If at this time the spleen and stomach function is damaged, the blood biochemical source is deficient, the patient's nutritional status is low, the healthy qi is deficient, 4 Computational and Mathematical Methods in Medicine and the human body's ability to remove pathogenic factors is reduced, thus prolonging the course of sepsis. The essence of acupuncture is to stimulate healthy qi by triggering and strengthening the body's homeostasis function and regulating the body's innate immunity, so as to assist the weakness and relieve the strong [23]. Acupuncture can play a two-way regulatory role in gastrointestinal tract, and has its special advantages in the treatment of acute and critical patients [24]. ...
... 41 HPM, as a type of moxibustion, has the functions of dispelling cold, warmly lubricating, and improving the 1710 function of meridians, and has been widely used in the treatment of various diseases. [42][43][44] It has been suggested that HPM is effective in treating CD patients. 45,46 However, whether HPM can regulate lncRNAs in CD development and progression is still vastly unknown, and the role of HPM in regulating ceRNA in the development of CD has not been comprehensively explored. ...
... Our results showed phosphorylation of cofilin on serine 3 upon paladin depletion. Phosphorylation of cofilin releases it from actin, and inhibits its ability to depolymerise F-actin, reducing the cellular concentration of G-actin and consequently decreasing the turnover rate of actin filaments required for filopodia construction at the leading edge of the migratory cell [32]. A recent report showed a link between cofilin phosphorylation and SRC/AKT/mTOR pathway in melanoma [13]. ...
... Identification of NSUN5 as another frequently altered regulator in PRAD is also well aligned with the literature. A pan-cancer study illustrated that NSUN5 was overexpressed in various cancers, like glioblastoma multiforme, BLCA, PRAD, and breast invasive carcinoma (BIC) [50]. Furthermore, it has been documented that NSUN5 promotes CRC development by enhancing cell proliferation [51], which is in line with another study underlining the confining effect of NSUN5 deficiency on the proliferation and growth rate of mammalian cells [14]. ...
... e total symptom scores of the two groups were compared, and the improvement rate of symptom scores was calculated. e improvement rate of points ≥70% was considered effective, the improvement rate of points ≥30% was considered effective, and the improvement rate of points <30% was considered ineffective [23][24][25]. e difference between the fatigue levels of the three groups before chemotherapy was not statistically significant (P > 0.05), but after chemotherapy (day 3), their fatigue levels were significantly higher (P > 0.01). Although there was no significant advantage in the acupuncture intervention group compared with the western ginseng group (P > 0.05), it also showed the effectiveness of acupuncture intervention (shown in Table 4). ...
... It uses the warm and medicinal power of ignited moxa to stimulate acupoints or specific parts of the surface of the body and promote the self-regulation function of the body. Moxibustion regulates intestinal inflammation, alleviates visceral hypersensitivity, and relieves visceral pain to improve functional gastrointestinal disorders (18,49,50). Acupoint application is a compound treatment method that integrates acupoints, meridians, and herbs that regulate meridians and improve blood circulation, thus exerting an effect on the intestinal system and improving diarrhea symptoms. ...
... Herb-partitioned moxibustion has definite efficacy in the treatment of CD [18,19], but its mechanism of action needs to be further elucidated. Using RNA-seq high-throughput sequencing, our preliminary study demonstrated that herbpartitioned moxibustion could regulate autophagy and immune gene expression in CD [20]. erefore, in this study, we further observed the effect of herb-partitioned moxibustion on the expression of autophagy-related proteins and immune-related factors in CD rat colon tissues. ...
... Acupoints such as ST36 (Zusanli) and EX-LE5 (Xiyan) were usually used in the treatments of knee osteoarthritis (Ma et al., 2018;Tong et al., 2021;Tian et al., 2022;Wei et al., 2022). To relieve diarrhea-predominant irritable bowel syndrome, ST36 and ST37 (Shangjuxu) were chosen with the highest frequency during the moxibustion treatments (Wang et al., 2018;Bao et al., 2019;Dai et al., 2022). Acupoints like ST36, SP6 (Sanyinjiao), BL23 (Shenyu), etc. were frequently used to improve immune function (Shih et al., 2018(Shih et al., , 2021Li et al., 2021;Oh and Kim, 2021;Ramires et al., 2021;Zhu et al., 2022). ...