Qian Zhang's research while affiliated with Osaka University and other places

What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.

It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.

If you're a ResearchGate member, you can follow this page to keep up with this author's work.

If you are this author, and you don't want us to display this page anymore, please let us know.

Publications (4)

Fig. 1. Ssmem1 is a conserved testis-specific gene.
Fig. 4. Ssmem1 KO sperm show morphology and motility defects. (A) SEM...
Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice
Article
Full-text available
  • Apr 2020
Globozoospermia (sperm with an abnormally round head shape) and asthenozoospermia (defective sperm motility) are known causes of male infertility in human patients. Despite many studies, the molecular details of the globozoospermia etiology are still poorly understood. Serine-rich single pass membrane protein 1 (Ssmem1) is a conserved testis-specif...
Cite
Download full-text
Cite
Request full-text
Figure 1. Conservation of the testis-enriched genes among species. The...
Figure 2. Digital PCR depicting the average TPM value per tissue per...
Figure 4. Phenotypic analysis of Mgat4d knockout male mice. (A) Genomic...
CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice
Article
Full-text available
  • Jun 2019
More than 1,000 genes are predicted to be predominantly expressed in mouse testis, yet many of them remain unstudied in terms of their roles in spermatogenesis and sperm function and their essentiality in male reproduction. Since individually indispensable factors can provide important implications for the diagnosis of genetically-related idiopathi...
Cite
Download full-text
Fig. 1. RT-PCR analysis of genes that were mutated using homologous...
Table 1 . Average litter size of control and KO mice (homologous...
Fig. 2. RT-PCR analysis of the genes that were mutated using...
Fig. 3. Conservation of all genes in this study. The presence of...
Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice
Article
Full-text available
  • Jun 2016
Significance In the mouse genome, thousands of genes are predominantly expressed in the testis, where these genes are thought to play important roles in spermatogenesis and fertilization. However, in this study, we report that 54 evolutionarily conserved and testis-enriched genes are not essential individually for male mouse fertility. Because the...
Cite
Download full-text

Citations

... In mice, this gene has been related to late gestational embryonic lethality when a loss of function occurs [63]. Recently, Zhang, et al. [64] demonstrated the effects of NRF1 on steroidogenesis and cell apoptosis in goat luteinized granulosa cells. An attenuated expression of NRF1 led to mitochondrial dysfunction, disrupted the cellular redox balance, impaired steroid synthesis, and finally resulted in granulosa cell apoptosis through the mitochondria-dependent pathway. ...
Reference: Estimation of the Genetic Components of (Co)variance and Preliminary Genome-Wide Association Study for Reproductive Efficiency in Retinta Beef Cattle
View full-text
... Knockout males showed normal fertility, suggesting that these 34 genes are dispensable for male fertility. According to the authors, disseminating this informa-tion to the scientific community is of pivotal importance to avoid unnecessary expenditure of time and research funds on these targets [142]. ...
Reference: The Renaissance of Male Infertility Management in the Golden Age of Andrology
View full-text
... These biased approaches of targeting known genes in known reproductive pathways have also provided information about what may not be effective contraceptive targets. For example, mutagenesis analysis has demonstrated that some evolutionarily conserved genes that are expressed in the reproductive tract are nonessential for reproductive success (Miyata et al., 2016). Moreover, some human mutations that are predicted to be deleterious have not resulted in infertility phenotypes when modeled in the mouse (Singh and Schimenti, 2015). ...
Reference: Reproductive genomics of the mouse: implications for human fertility and infertility
View full-text