Priscila de Camargo Smolarek’s research while affiliated with State University of Ponta Grossa and other places

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Publications (2)


Figure 1. Flow chart.
Figure 2. Illustration of points and lines for the craniofacial morphology variables (Björk [15]). s = sella; n = nasion; ss = subspinale; pg = pogonion; NSL = nasionsella-line; NL = nasal-line; ML = mandibular-line. Sagittal variables: sagittal jaw relation (ss-n-pg), maxillary prognathia (s-n-ss), mandibular prognathia (s-n-pg). Vertical variables: vertical jaw relation (NL/ML), maxillary inclination (NSL/NL), mandibular inclination (NSL/ML).
Differences between the groups
Difference between the two groups adjusted for age, gender and body mass index (BMI)
Craniofacial Morphology and Upper Airway Dimensions in Patients with Hypermobile Ehlers-Danlos Syndrome Compared to Healthy Controls
  • Article
  • Full-text available

June 2021

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99 Reads

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2 Citations

Journal of Oral and Maxillofacial Research

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Priscila de Camargo Smolarek

Objectives: The aims of the present case-control study were to compare craniofacial morphology, airway minimum cross-sectional area and airway volume between patients with hypermobile Ehlers-Danlos syndrome and healthy controls. Material and Methods: The sample comprised 18 hypermobile Ehlers-Danlos syndrome (hEDS) patients (16 females, 2 males, mean age 34.1 [SD 10.35] years), clinically diagnosed and genetically tested in order to exclude other types of EDS, and 16 controls (14 females, 2 males, mean age 37.9 [SD 10.87] years) with neutral occlusion and normal craniofacial morphology. Craniofacial morphology was assessed on lateral cephalograms. Minimum cross-sectional area and upper airway volume were assessed on cone-beam computed tomography and analysed by standard and well-validated methods. Differences were tested by logistic regression analysis adjusted for age, gender and body mass index (BMI). Results: No significant differences in craniofacial morphology were found between hEDS patients and controls. Airway minimum cross-sectional area (P = 0.019) and airway volume (P = 0.044) were significantly smaller in hEDS patients compared to controls. When adjusted for age, gender and BMI no significant differences were found. However, minimum cross-sectional area was almost significant (P = 0.077). Conclusions: The craniofacial morphology and airway dimensions of hypermobile Ehlers-Danlos syndrome patients were comparable to controls, with a tendency towards a smaller minimum cross-sectional area in the hypermobile Ehlers-Danlos syndrome group. The results may prove valuable for understanding the effect of hypermobile Ehlers-Danlos syndrome on craniofacial morphology and the upper airways.

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Figure 1. Clinical aspects of small oral leucoplakia located on the tongue's left lateral border.
Figure 2. Features microscopic with a stratified and keratinized pavement epithelium, with cellular atypia, and tissue architecture alteration (haematoxylin and eosin stain, original magnification x100).
Figure 3. Alterations cytological with the presence of hyperchromatism and nuclear pleomorphism (haematoxylin and eosin stain, original magnification x200).
Figure 4. Alterations in architecture with the drop projection of epithelial tissue (black arrows) (haematoxylin and eosin stain, original magnification x200).
Small Dysplastic Oral Leucoplakia in a Smoking Woman: a Case Report

March 2021

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187 Reads

Journal of Oral and Maxillofacial Research

Background: Oral leucoplakia is clinical term used to describe white plaques, and that is part of the group of oral potentially malignant disorders. Leucoplakia may show epithelial dysplasia, mainly in harder smoking patient. This case report discusses a small leucoplakia with dysplasia on the tongue's lateral border in a woman, diagnosed early after a routine clinical consultation. Methods: A 57-year-old female patient consulted to the Oral Diagnosis and Surgery Service of the State University of Ponta Grossa, Brazil. First, the patient was referred for the extraction of her lower incisors due to periodontal disease. During clinical examination, was identified a sessile white plaque, of small size, and located on the tongue's left lateral border. Thus, the lesion's diagnostic hypothesis was oral leucoplakia due to patient be chronic smoker for 40 years. The incisional biopsy was performed, with the epithelial tissue and part of the connective tissue removed. Results: The histopathological examination revealed a stratified and keratinized pavement epithelium, with cellular atypia, and presence of hyperchromatism and nuclear pleomorphism. However, the alterations were restricted to the epithelium's basal, characterizing a mild dysplasia. The proposed treatment was surgical removal of the lesion, and the patient was also instructed to quit smoking, as well as she continues to follow-up. Conclusions: The presented case emphasizes the importance of early diagnosis and the orientation of risk factors to smoking patients, even in small lesions that can clinically appear harmless.

Citations (1)


... This case-control study was performed at the Resource Centre for Rare Oral Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, between September 2022 and June 2023. The present study was conducted according to a standardised protocol validated in previous studies in patients with Ehlers-Danlos syndrome [22][23][24]. Power calculation was performed prior to the study based on a previous study which reported that 8% of healthy adults have dental enamel defects [25]. If 50% of patients with HPP have dental enamel defects with a risk of type 1 error of 5% and type 2 error of 20% and an 80% chance of detecting a difference between the two groups, the power calculation shows that approximately 18 participants are needed in each group to detect a significant difference. ...

Reference:

Oro-Dental Characteristics in Patients With Adult-Onset Hypophosphatasia Compared to a Healthy Control Group-A Case-Control Study
Craniofacial Morphology and Upper Airway Dimensions in Patients with Hypermobile Ehlers-Danlos Syndrome Compared to Healthy Controls

Journal of Oral and Maxillofacial Research