Prathima Nandivada's research while affiliated with Beth Israel Deaconess Medical Center and other places

Publications (8)

Article
Fecal incontinence is a significant source of morbidity and decreased quality of life (QOL) for many. Until recent years, few therapies beyond medical management were available for patients. Surgical treatment of fecal incontinence has evolved from colostomy and direct repair of muscle defects to interventional techniques such as nerve stimulation...
Article
Background: Prosthetic graft infection is a major complication of peripheral vascular surgery. We investigated the experience of a single institution over 10 years with bypass grafts involving the femoral artery to determine the incidence and risk factors for prosthetic graft infection. Methods: A retrospective cohort single-institution review o...
Article
The introduction of endovascular aneurysm repair has resulted in a decline in open abdominal aortic aneurysm repairs performed by vascular residents. The purpose of this study was to evaluate if a similar trend has occurred with open lower extremity revascularization procedures, with increased endovascular procedures producing a decrease in the num...
Article
The principles of surgical management of inflammatory bowel disease (IBD) continue to evolve with advances in medical therapy, surgical technique, and minimally invasive operative technology. The purpose of this review is to highlight such advances in colorectal and anorectal surgery for IBD over the last year. Treatment of ulcerative colitis and C...
Article
Full-text available
Laser-induced vessel wall injury leads to rapid thrombus formation in an animal thrombosis model. The target of laser injury is the endothelium. We monitored calcium mobilization to assess activation of the laser-targeted cells. Infusion of Fluo-4 AM, a calcium-sensitive fluorochrome, into the mouse circulation resulted in dye uptake in the endothe...
Article
The endothelium serves as a metabolically active interface between the blood and underlying tissues and offers response to changes in its microenvironment. The endothelium is rapidly activated in response to stimuli associated with fluctuations in shear stress, physical trauma, oxidative stress, and thrombotic and inflammatory mediators. To study e...

Citations

... The physiopathology of ASI is not completely understood but results from a functional impairment of one or more of the four anatomic components that allow a normal continence: The internal anal sphincter (IAS), the external anal sphincter (EAS), the pelvic floor muscles and the sensory-motor apparatus [3]. ASI is primarily managed conservatively but sphincter repair surgery is proposed for large defects of either EAS, IAS or both with conservative treatment failure [4,5]. However, long-term results of anal sphincter ...
... With regard to the relationship between diabetes and SSIs, Martin showed that this association was significantly higher for cardiac surgery compared to other types of surgical interventions, and that diabetes was identified as an independent risk factor for multiple types of surgical procedures [12]. Furthermore, Jeffrey showed that the rate of graft infection involving femoral artery was significantly more frequent in patients with diabetes compared with patients without this pathology (6.5% vs. 1.9%; p < 0.01), having a total graft infection frequency of 3.8% [13]. ...
... In fact, there was a disproportionate increase in common femoral endarterectomy, which could be attributed to the gradual replacement of aorto bifemoral reconstruction with hybrid common femoral endarterectomy with iliac stent/stent graft. [7] This showed that majority of the lower limb bypasses and complex procedures were being performed only in centers with vascular surgery training programs and not in the nonteaching hospitals. This leads to less experience and confidence to do open surgeries among the younger vascular surgeons. ...
... Simple fistulae are located below the dentate line and have single opening and no associated stricture or abscesses. In the treatment of simple fistulae, together with antibiotic use including systemic and topical treatment, and surgical therapy in the form of simple fistulotomy, or placement of noncutting seton, 80 -100% of patients heal [13,14]. Uncomplicated fissures may be treated with topical therapy including sitz baths and topical ointments. ...
... Under physiological conditions, endothelial cells form a non-adhesive surface that prevents platelet activation and coagulation cascades [17]. Once the vascular endothelium is damaged and exfoliated, the exposed subendothelial tissue (collagen) and the platelets in contact with it will be activated, resulting in thrombosis [18]. The damage of endothelial cells leads to the activation of coagulation factors, which dominates the coagulation mechanism in the body and leads to thrombosis [19]. ...