Pralisha Maharjan’s scientific contributions

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Publications (1)

Figure 1 A. Preoperative MRI brain revealing a hyperintense lesion on T2-weighted image on axial plane measuring 4.2 cm × 4.0cm × 1.4cm. B. Postoperative MRI brain revealing heterogenous collection at tumor resection bed in right lateral aspect of posterior fossa where central component of the collection displays mixed signal.
Figure 2. A. Gross image appeared greyish white to greyish brown nodular tissue. B. Cut section showed solid to cystic area. Microscopic examination revealed tumor tissue predominantly composed of cribriform growth pattern with nest of tumor cells with discrete, rounded punched out gland like spaces filled with eosinophilic to basophilic material (Figure 3A). Area of tubular pattern with multiple ducts and tubules like structure are lined by small uniform cuboidal epithelium (Figure 3B). A focus of solid sheets of tumor cells (<30% solid component) noted. Infiltrating tumor nests are identified within fibrous stroma. Perineural invasion is evident. Focal areas of reactive gliosis with dilated and congested blood vessels are noted.
Figure 3. A.Tumor tissue predominantly composed of cribriform growth pattern with nest of tumor cells with discrete, rounded punched out gland like spaces filled with eosinophilic to basophilic material (Hematoxylin and Eosin stain x10). B. Area of tubular pattern with multiple ducts and tubules like structure are lined by small uniform cuboidal epithelium (Hematoxylin and Eosin stain x40).
Figure 3. A. The tumor cells expressed CD117 positivity in luminal layer. B and C.The tumor cells expressed P40 and CK7 in myoepithelial layer. D. Ki-67 was nearly 12%
Primary Intracranial Adenoid Cystic Carcinoma: A Case Report
  • Article
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January 2025

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JNMA; journal of the Nepal Medical Association

Pralisha Maharjan

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Reena Rana

Adenoid cystic carcinoma (ACC) is a rare slow-growing but aggressive malignant tumor arising from the epithelial cells of mucous-secreting glands. Primary intracranial ACC is one of the rarest entity. We report a case of a 61 years old male presenting with difficulty in swallowing, slurring of speech, generalized body weakness. Patient had residual right cerebellopontine angle (CPA) mass causing midline shift and fourth ventricular obstruction on MRI. Patient underwent right retrosigmoid craniotomy with excision of CPA mass. Histopathological examination confirmed the case as primary intracranial ACC.

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