Pooja Rai’s research while affiliated with Hygia Institute of Pharmaceutical Education and Research and other places

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Publications (2)


Table 1 The procedure used in CUS. 
Fig. 1. Effect of Oxitard on ex vivo antioxidant properties in CS model Values are expressed as mean ± SD. (n ¼ 6) Significant values were compared with ***p < 0.001 vs CS group, **p < 0.01 vs CS group & ### p < 0.001 vs control group. 
Fig. 2. Effect of Oxitard on ex vivo antioxidant properties in CUS model Values are expressed as mean ± SD. (n ¼ 6) Significant values were compared with ***p < 0.001 vs CUS group, **p < 0.01 vs CUS group & ### p < 0.001 vs control group. 
Fig. 3. Effect of Oxitard on hematological parameters in CS induced stress in rats. Values are expressed as mean ± SD. (n ¼ 6) Significant values were compared with ***p < 0.001 vs CS group, **p < 0.01 vs CS group & ### p < 0.001 vs control group. 
Fig. 4. Effect of Oxitard on organ weight in CS induced-stress rats. Values are expressed as mean ± SD. (n ¼ 6) Significant values were compared with ***p < 0.001 vs CS group, **p < 0.01 vs CS group & ###p < 0.001 vs control group. 

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Adaptogenic potential of Oxitard in experimental chronic stress and chronic unpredictable stress induced dysfunctional homeostasis in rodents
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July 2017

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146 Reads

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6 Citations

Journal of Ayurveda and Integrative Medicine

Brajnandan Kishor

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Pooja Rai

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Rakesh Bharatia

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[...]

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Anshuman Sinha

Background: Oxitard, a polyherbal formulation comprising the extracts of Withania somnifera, Mangifera indica, Glycyrrhiza glabra, Daucus carota, Vitis vinifera, powders of Syzygium aromaticum, Yashada bhasma and Emblica officinalis; and oils of Triticum sativum. Objective: Current study deals with the assessment of Oxitard (a marketed polyherbal formulation) for its adaptogenic potential in chronic unpredictable stress (CUS) and chronic stress (CS) induced dysfunctional homeostasis in rodents. Materials & methods: Animals were immobilized for 2 h every day for ten days to induce CS. In order to induce CUS, animals were employed in a battery of stressors of variable value and duration for ten days. Following administration of Oxitard, stress was induced in the animals. Stress-induced efficient changes were evaluated by assessing organ (adrenal gland) weights, ulcer index, hematological parameters and biochemical levels of reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and catalase (CAT). Results: CS and CUS significantly modified the oxidative stress parameters (increased MDA and decreased GSH). Furthermore, CS and CUS lead to weight reduction, adrenal hypertrophy and gastric ulceration. Pre-treatment with Oxitard (200 and 400 mg/kg, p.o.) significantly modified CS and CUS induced hematological changes, oxidative stress parameters and pathological effects. Conclusion: In conclusion, Oxitard-intervened antioxidant actions are accountable for its adaptogenic effects in stress-induced dysfunctional homeostasis.

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Citations (2)


... Plant compounds, such as those found in Oxitard, a phytopharmaceutical formulation containing a combination of Mangifera indica Linn, Glycyrrhiza glabra Linn, Syzygium aromaticum Linn, Vitis vinifera Linn, and Withania somnifera, have the potential to affect a wide variety of cellular functions and have significant disease-fighting potential [12,13]. Oral administration of Oxitard has been shown to increase antioxidant status and reduce lipid peroxidation (LPO) [14,15]. This slowing down of oxidation reactions protects against damage caused by LPO or free radicals, thereby protecting vital organs and maintaining the individual's health. ...

Reference:

The Protective Effect of Oxitard on Sperm Function and Antioxidant Status in Rats Exposed to Swimming Stress
Adaptogenic potential of Oxitard in experimental chronic stress and chronic unpredictable stress induced dysfunctional homeostasis in rodents

Journal of Ayurveda and Integrative Medicine

... The authors claimed that the antioxidant activity of minocycline is implicated in the neuroprotective effects [6]. Furthermore, some reports are indicating the cognition-enhancing and neuroprotection potential of minocycline in Aβ, streptozotocin, and lipopolysaccharide (LPS)-injured animals [8,42,43]. The previous evidence was in line with our findings [6,8,42,43]. ...

Synergistic Neuroprotective Potential of Combined Treatment with Vinpocetine and Minocycline Against Streptozotocin and Lipopolysaccharide Induced Memory Impaired Mice
  • Citing Article
  • June 2017

Journal of Pharmaceutical Sciences and Pharmacology