Pilar Nicasio-Torres's research while affiliated with Mexican Institute of Social Security and other places

Publications (12)

Article
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Tagetes lucida has been widely used as a folk remedy in illnesses associated with the central nervous system and inflammatory ailments. Among the chemical compounds that stand out in the plant against these conditions are coumarins, such as 7-O-prenylscopoletin (PE), scoparone (SC), dimethylfraxetin (DF), herniarin (HR), and 7-O-prenylumbelliferone...
Article
Calli and cells in suspension of Tilia americana produce coumarins and triterpenes compounds with anti-inflammatory activity. Tilia americana var. mexicana is a species identified in Mexico as in danger of extinction. This tree is used in Mexican traditional medicine to treat diseases related to inflammation and nervous sufferings; tiliroside, iso-...
Article
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Sphaeralcea angustifolia (Cav) G. Don is used in traditional Mexican medicine to treat inflammations and gastric disease. Its anti-inflammatory and immunomodulatory activities in mice and rats acute and chronic models have been attributed mainly to scopoletin. Scopoletin reduced joint inflammation, the number of new vessels, production of endogenou...
Article
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A histological analysis was performed with the aim of elucidating the spontaneous regeneration process of the hairy root lines LRT 2.3 and LRT 6.4, derived from Lopezia racemosa leaf explants and genetically transformed with the Agrobacterium rhizogenes strain ATCC15834/pTDT. The analysis showed both lines regenerate via indirect somatic embryogene...
Article
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Sphaeralcea angustifolia has been widely used in inflammatory conditions such as blows, bruises, fractures, and wounds. The compounds identified as active in plants and suspension cell culture of S. angustifolia were tomentin, scopoletin, and sphaeralcic acid. To consolidate the integral use of knowledge about the S. angunstifolia and strengthen it...
Article
Sphaeralcea angustifolia (Cav.) G. Don (Malvaceae) is a plant used in inflammatory illnesses. The scopoletin was the main responsible compound for the anti-arthritic effect in this species. The therapeutic effectiveness of a S. angustifolia dichloromethane extract gel standardized in scopoletin was confirmed in patients with osteoarthritis. Cells i...
Article
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The aerial tissues of Tilia americana var. mexicana produce compounds with anxiolytic activity, such as quercetin 3-O-β-d-glucoside and tiliroside, in addition to ones with anti-inflammatory properties, such as scopoletin. These three compounds were initially identified in callus cultures of apical buds. In the present study, suspension cultures fr...
Article
Full-text available
Tilia americana var. mexicana is used in Mexican traditional medicine to treat anxiety and inflammatory processes. Several glycosides derived from quercetin and kaempferol, including tiliroside, isoquercetin, and quercetin-3-β-d-glucoside, were reported as the main anxiolytic compounds in this species; to our knowledge, compounds with anti-inflamma...
Article
Cells in suspension from Sphaeralcea angustifolia produce compounds with anti-arthritic activity (scopoletin, tomentin, and sphaeralcic acid) in Murashige and Skoog (MS) medium with 2.74 mM of total nitrate content. The effect of nitrate and copper contents in the MS medium on the growth of cell suspension and the production of active compounds wer...
Article
The aerial parts of Ageratina pichinchensis are used in Mexican traditional medicine for the treatment of skin wounds. Recently, it was demonstrated that the aqueous extract of this plant reduced the time required to cicatrize a wound induced in the rat. The same extract showed a capability to induce overgrowth in normal fetal lung cells (MRC-5). T...
Article
Ethnopharmacological relevance: Sphaeralcea angustifolia Cavanilles & Don (Malvaceae), known in Mexico as "Vara de San José", is used in Mexican Traditional Medicine as an anti-inflammatory and, more specifically, for treating rheumatism. Anti-inflammatory properties have been demonstrated in different pharmacological models. Aim of the study: T...
Article
Cecropia obtusifolia and Marrubium vulgare have been widely used in Mexican traditional medicine for the control of type 2 diabetes. In order to evaluate the clinical effect produced by the aqueous extract from these species on type 2 non-controlled diabetes mellitus, a total of 43 outpatients were included. Based on the European NIDDM (policy grou...

Citations

... (Wang et al. 2008), Beta vulgaris L. (Ninkovíc et al. 2010), Gentiana macrophylla Pall. (Wu et al. 2011), Salvia miltiorrhiza Bunge (Wang et al. 2013), and Lopezia racemose (Vargas-Morales et al. 2022). Moreover, plantlet regeneration directly from hairy root cultures has been reported several times, and may be dependent on the photoperiod. ...
... Schematic representation for mass galanthamine production sphaeralcic acid, two biomolecules with anti-inflammatory and immunomodulatory activities, than that in wild S. angustifolia plants. Additionally, metabolites biosynthesis was 263 times higher when cultured in flasks and 5 times higher in a stirred tank type bioreactor(Reyes-Pérez et al. 2021). ...
... The volume of distribution (Vd), mean residence time (MRT), elimination half-life (t1/2), and area under the plasma concentration-time curve from 0 h to infinity (AUCinf) were determined after intravenous administration of MeP-loaded NPs to animals. All calculations were performed using the PKSolver add-in program for Microsoft Excel [114]. ...
... The regression equation for scopoletin was (y) = 165,407 (x) + 16,720, r 2 = 0.9993, and for sphaeralcic acid it was (y) = 7381.9 (x) + 1362.2, r 2 = 0.9998, with r 2 > 0.99 (Nicasio-Torres et al. 2016;Serrano-Román et al. 2020). ...
... Within the first group, the amount of quercetin varied from 6.6 and 7.4 mg/100 g DW, reported, respectively in Tilia americana [28] and Clinacanthus nutans [29] suspension cultures, to the 14.6 and 23 mg/100 g DW found in calli of Pluchea lanceolata [30] and Centella asiatica [31], and up to 125 mg/100 g DW from cultures of Helicteres angustifolia [32]. Interestingly, Cisnero-Torres and coworkers also investigated the quercetin amount in the explants used to generate the calli, finding that quercetin content in leaves of C. nutans was slightly higher than calli (12 versus 7.4 mg/100 g DW) [28]. ...
... Secondary metabolites can affect cancer cells by interfering with their division, and by changing their metabolism and even the expression of selected genes. Many also have antioxidant [15,16], anti-inflammatory [17,18], antibacterial [19], antifungal [20,21], neurological [22] or hepatoprotective [23] effects. As plants represent such an important source of many secondary metabolites, there is great interest in increasing their biosynthetic rates as part of green biotechnology, which includes the use of transgenic plants or other photosynthetic organisms for industrial purposes. ...
... μg/L), sphaeralcic acid (1441.00 μg/L), and scopoletin (999.00 μg/L) was obtained in Sphaeralcea angustifolia with 2.74 mM total nitrate (Perez-Hernandez et al. 2019). Many plant cell cultures have also been used to convert precursors into products by utilizing preexisting enzyme systems. ...
... For example, in A. espinosarum, Díaz-Peralta et al. [33] recorded up to 20 compounds among the most relevant neo-clerodane diterpenes, flavonols, flavanones and flavones: taxifolin, naringenin, sakuranetin, persicogenin, apigenin, acacetin and kaempferol. In A. pichinchensis, Romero-Cerecero et al. [34] determined chlorogenic acid and glycosylated flavonoids. In A. petiolaris, Bustos-Brito et al. [11] isolated chlorogenic acid, L-chiro-inositol, benzyl 2-hydroxy-6-methoxybenzoate, benzyl 2-hydroxy-3,6-dimethoxybenzoate and 2α-tigloyloxyeperuic acid for the first time. ...
... Extracts from aerial tissues of this plant had demonstrated anti-inflammatory activity, with scopoletin identified as the main active compound (Meckes et al. 2004;Juárez-Ciriaco et al. 2008;García-Rodríguez et al. 2012). Topical administration of a gel formulation prepared with 1% of S. angustifolia dichloromethane extract standardized in the scopoletin content showed therapeutic effectiveness and tolerability in patients with osteoarthritis of hands, capable of reducing the associated symptoms: pain, inflammation and joint stiffness (Romero-Cerecero et al. 2013). ...
... There are contradictory literature data on the hypoglycemic activity of horehound. According to one source, aqueous horehound extract did not significantly reduce blood glucose levels [2], while according to another source, its administration induced a significant reduction in glucose levels in rats [3]. The variation in the results is most likely a consequence of the collection of plant material from different localities, which greatly affects the quality and quantity of the secondary metabolites, together with the use of different parts of the plant and different extraction methods. ...