Philippe Peigneux's research while affiliated with Université Libre de Bruxelles and other places
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Publications (301)
Mind-wandering is a mental state in which attention shifts from the present environment or current task to internally driven, self-referent mental content. Homeostatic sleep pressure seems to facilitate mind-wandering as indicated by studies observing links between increased mind-wandering and impaired sleep. Nevertheless, previous studies mostly r...
Motor adaptation reflects the ability of the brain's sensorimotor system to flexibly deal with environmental changes to generate effective motor behaviour. Whether sleep contributes to the consolidation of motor adaptation remains controversial. In this study, we investigated the impact of sleep on motor adaptation and its neurophysiological correl...
Learning and consolidation of motor skills dynamically evolve both online during practice and offline after training. We investigated using magnetoencephalography the neural dynamics underpinning motor learning and its consolidation in relation to sleep during resting-state periods shortly after the end of learning (short-term boost window, within...
Functional connectivity (FC) during sleep has been shown to break down as non-rapid eye movement (NREM) sleep deepens before returning to a state closer to wakefulness during rapid eye movement (REM) sleep. However, the specific spatial and temporal signatures of these fluctuations in connectivity patterns remain poorly understood. This study aimed...
Diffusion-weighted magnetic resonance imaging (DWI) allows the observation of (micro)structural brain remodelling in cortical and subcortical regions after time-limited motor learning. Post-learning sleep consolidation should lead to long-term microstructural brain changes, but concrete evidence remains limited. Here, we used both conventional diff...
Motor adaptation reflects the ability of the sensorimotor system in the brain to flexibly deal with changes in the environment to generate effective motor behaviour. How and whether sleep contributes to the consolidation of motor adaptation remains elusive. In this study, a new motor task was employed which utilizes a highly automatized motor skill...
Presentation of learning-related cues during NREM sleep has been shown to improve memory consolidation. Past studies suggest that REM sleep may contribute to the beneficial effect of reactivating memories during NREM sleep, but the relationship between REM sleep and induced reactivations in NREM remains unclear. We investigated whether a naturally...
Functional connectivity (FC) during sleep has been shown to break down as non-rapid eye movement (NREM) sleep deepens before returning to a state closer to wakefulness during REM sleep. However, the specific spatial and temporal signatures of these fluctuations in connectivity patterns remain poorly understood. The goal of this study was to investi...
Retrieving previously stored information makes memory traces labile again and can trigger restabilization in a strengthened or weakened form depending on the reactivation condition. Available evidence for long-term performance changes upon reactivation of motor memories and the effect of post-learning sleep on their consolidation remains scarce, an...
Evidence for sleep-dependent changes in microstructural neuroplasticity remains scarce, despite the fact that it is a mandatory correlate of the reorganization of learning-related functional networks. We investigated the effects of post-training sleep on structural neuroplasticity markers measuring standard diffusion tensor imaging (DTI), mean diff...
Dreams are often viewed as fascinating but irrelevant mental epihenomena of the sleeping mind with questionable functional relevance. Despite long hours of oneiric activity, and high individual differences in dream recall, dreams are lost into oblivion. Here, we conceptualize dreaming and dream amnesia as inherent aspects of the reactive and predic...
Echo planar imaging (EPI) is the most common approach for acquiring diffusion and functional MRI data due to its high temporal resolution. However, this comes at the cost of higher sensitivity to susceptibility-induced B0 field inhomogeneities around air/tissue interfaces. This leads to severe geometric distortions along the phase encoding directio...
Dreams are often viewed as fascinating but relatively irrelevant mental epihenomena of the sleeping mind with questionable or no functional relevance. Despite long hours of oneiric activity, and high individual differences in dream recall, dream amnesia is one of the most robust and universal features of dreaming. In this review, we conceptualize d...
Sleep continuity and efficacy are essential for optimal cognitive functions. How sleep fragmentation (SF) impairs cognitive functioning, and especially cognitive fatigue (CF), remains elusive. We investigated the impact of induced SF on CF through the TloadDback task, measuring interindividual variability in working memory capacity. Sixteen partici...
Lucid dreaming (LD) is a mental state in which we realize not being awake but are dreaming while asleep. It often involves vivid, perceptually intense dream images as well as peculiar kinesthetic sensations, such as flying, levitating, or out-of-body experiences. LD is in the cross-spotlight of cognitive neuroscience and sleep research as a particu...
Introduction
Impaired sleep quality is among the most common complaints in psychopathological conditions including psychotic states. The clinical relevance of sleep disruption is, however, notoriously overlooked and considered as a secondary symptom that automatically ameliorates if the mental problem is adequately treated. Nevertheless, research f...
Slow frequency activity during non-rapid eye movement (NREM) sleep emerges from synchronized activity of widely distributed thalamo-cortical and cortico-cortical networks, reflecting homeostatic and restorative properties of sleep. Slow frequency activity exhibits a reactive nature, and can be increased by acoustic stimulation. Although non-invasiv...
Echo planar imaging (EPI) is the most common approach for acquiring diffusion and functional MRI data due to its high temporal resolution. However, this comes at the cost of higher sensitivity to susceptibility-induced B0 field inhomogeneities around air/tissue interfaces. This leads to severe geometric distortions along the phase encoding directio...
Evidence for sleep-dependent changes in micro-structural neuroplasticity remains scarce, despite the fact that it is a mandatory correlate of the reorganization of learning-related functional networks. We investigated the effects of post-training sleep on structural neuroplasticity markers measuring standard diffusion tensor imaging (DTI) mean diff...
Motor learning induces frequency-specific changes to large-scale brain network connectivity during post-learning sleep
Previous research has shown that resting-state functional connectivity (rsFC) between different brain regions (seeds) is related to motor learning and motor memory consolidation. Using high-density electroencephalography (hdEEG), we addressed this question from a brain network perspective. Specifically, we examined frequency-dependent functional co...
Increasingly studied in a systematic manner since the 1970s, the cognitive processes of the brain taking place during sleeping periods remain an important object of scrutiny in the scientific community. In particular, sleep has been demonstrated to play a significant role for learning and memory consolidation processes, and sleep scientists have st...
Motor learning features rapid enhancement during practice then offline post-practice gains with the reorganization of related brain networks. We hypothesised that fast transient, sub-second variations in magnetoencephalographic (MEG) network activity during the resting-state (RS) reflect early learning-related plasticity mechanisms and/or interindi...
Previous research has shown that resting state functional connectivity (rsFC) between different brain regions (seeds) is related to motor learning and motor memory consolidation. Using high density electroencephalography (hdEEG) we addressed this question from a brain network perspective. Specifically, we examined frequency dependent functional con...
Studies investigating motor learning in patients with Multiple Sclerosis (MS) disease highlighted that MS patients exhibit similar learning performance than healthy controls, but that learning can be hampered by the progression of MS eventually leading to impaired efficiency of subcortical-cortical networks. We aimed at investigating whether the lo...
Sleep is known to benefit memory consolidation, but little is known about the contribution of sleep stages within the sleep cycle. The sequential hypothesis proposes that memories are first replayed during non-rapid-eye-movement (NREM or N) sleep and then integrated into existing networks during rapid-eye-movement (REM or R) sleep, two successive c...
Mind wandering (MW) is a highly prevalent phenomenon despite its negative consequences on behavior. Current views about its origin share the idea that MW occurs due to changes in the executive functions system. Here, we argue that not all instances of MW are necessarily related to changes in that system. Combining results from MW and sleep research...
The extent of high-level perceptual processing during sleep remains controversial. In wakefulness, perception of periodicities supports the emergence of high-order representations such as the pulse-like meter perceived while listening to music. Electroencephalography (EEG) frequency-tagged responses elicited at envelope frequencies of musical rhyth...
Targeted memory reactivation (TMR) and transcranial direct current stimulation (tDCS) can enhance memory consolidation. It is currently unknown whether TMR reinforced by simultaneous tDCS has superior efficacy. In this study, we investigated the complementary effect of TMR and bilateral tDCS on the consolidation of emotionally neutral and negative...
The Free and Cued Selective Reminding Test (FCSRT) is a largely validated neuropsychological test for the identification of amnestic syndrome from the early stage of Alzheimer’s disease (AD). Previous electrophysiological data suggested a slowing down of the alpha rhythm in the AD-continuum as well as a key role of this rhythmic brain activity for...
The Free and Cued Selective Reminding Test (FCSRT) is a largely validated neuropsychological test for the identification of amnestic syndrome from the early stage of Alzheimers disease (AD). Previous electrophysiological data suggested a slowing down of the alpha rhythm in the AD-continuum as well as a key role of this rhythmic brain activity for e...
The ‘catalogue of knowledge and skills’ for sleep medicine presents the blueprint for a curriculum, a textbook, and an examination on sleep medicine. The first catalogue of knowledge and skills was presented by the European Sleep Research Society in 2014. It was developed following a formal Delphi procedure. A revised version was needed in order to...
Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are associated with motor impairments, with some children holding a comorbid diagnosis of Developmental Coordination Disorder (DCD). However, DCD is underdiagnosed in these populations and the volume abnormalities that contribute to explaining these motor impairments...
Continuation of experience-dependent neural activity during offline sleep and wakefulness episodes is a critical component of memory consolidation. Using functional magnetic resonance imaging (fMRI), offline consolidation effects have been evidenced probing behavioural and neurophysiological changes during memory retrieval, i.e., in the context of...
Pediatric attention deficit/hyperactivity disorder (ADHD) is a heterogeneous condition. In particular, children with ADHD display varying profiles of dispositional traits, as assessed through temperament and personality questionnaires. Previous data-driven community detection analyses based on temperament dimensions identified an irritable profile...
When presented with novel but semantically related elements after learning verbal material, healthy participants tend to endorse these items as previously learned. This reflects the normal integration and association of novel verbal information into long-term memory. How obstructive sleep apnoea (OSA) negatively impacts verbal memory performance, a...
State modeling of whole-brain electroencephalography (EEG) or magnetoencephalography (MEG) allows to investigate transient, recurring neurodynamical events. Two widely-used techniques are the microstate analysis of EEG signals and hidden Markov modeling (HMM) of MEG power envelopes. Both reportedly lead to similar state lifetimes on the 100 ms time...
Due to the COVID-19 pandemic, populations from many countries have been confined at home for extended periods of time in stressful environmental and media conditions. Cross-sectional studies already evidence deleterious psychological consequences, with poor sleep as a risk factor for impaired mental health. However, limitations of cross-sectional a...
The linearly constrained minimum variance beamformer is frequently used to reconstruct sources underpinning neuromagnetic recordings. When reconstructions must be compared across conditions, it is considered good practice to use a single, “common” beamformer estimated from all the data at once. This is to ensure that differences between conditions...
Encoding in episodic memory is a step often impaired in patients with amnestic Mild Cognitive Impairment (aMCI). However, procedural memory processes are still relatively preserved. In line with previous research on the enactment effect, we investigated the potential benefit of encoding words combined with imitative gestures on episodic memory. Bas...
Neuroplasticity refers to the fact that our brain can partially modify both structure and function to adequately respond to novel environmental stimulations. Neuroplasticity mechanisms are not only operating during the acquisition of novel information (i.e., online) but also during the offline periods that take place after the end of the actual lea...
The overlap/distinctiveness between Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) has been increasingly investigated in recent years, particularly since the DSM-5 allows the dual diagnosis of ASD and ADHD, but the underlying brain mechanisms remain unclear. Although both disorders are associated with brain volum...
How does sleep affect our brain functioning, and what happens when we do not receive our necessary “portion” of sleep? It is a well-known fact that sleep is essential for restoration of body and mind efficiency, while a lack of appropriate sleep adversely impacts mood, motor functions, and cognition, eventually affecting the quality of everyday lif...
‘Management of Sleep Disorders in Psychiatry’ provides an in-depth and evidence-based review of sleep-wake disorders included in Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) that are associated with a range of psychiatric disorders including mood, anxiety, psychotic, neurocognitive, eating, and substance use disorders....
Continuation of experience-dependent neural activity during offline periods of sleep and wakefulness is a critical element of memory consolidation. Using functional magnetic resonance imaging (fMRI), offline consolidation effects have been evidenced probing behavioral and neurophysiological changes during memory retrieval, i.e. in the context of ta...
Due to the COVID-19 pandemic, populations from many countries have been confined at home for extended periods of time in stressful environmental and media conditions. Cross-sectional studies already evidenced deleterious psychological consequences, with poor sleep as a risk factor for impaired mental health. However, limitations of cross-sectional...
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Mind wandering (MW) is a highly prevalent phenomenon despite its negative consequences on behaviour. Current views about its origin share the idea that MW occurs due to changes in the executive functions system. Here, we argue that not all instances of MW are necessarily related to changes in that system. Combining results from MW and sleep researc...
Post-learning slow wave sleep (SWS) is known to support declarative memory consolidation. As SWS is more abundant in young population, we suggested that sleep-dependent memory consolidation processes could occur at a faster pace in school-aged children. After learning new associations between non-objects and their functions, retrieval performance w...
Recent advances shifted the focus on single-brain functioning toward two-brain communication during learning interactions, following the demonstration that interpersonal brain synchronization (IBS) can track instructor-learner information exchange. Here, we investigated (i) whether sleep deprivation (SD) that potentially impacts both social interac...
The consolidation of motor memory is a non-linear temporal dynamic. There are critical time points at which post-training performance can improve (e.g., 30 min and 24 h) or merely stabilize (e.g., 4 h). Besides, neuronal plasticity is supported by synchronized oscillatory activity in and between brain areas at play during the acquisition and consol...
Human brain activity is intrinsically organized into resting-state networks (RSNs) that transiently activate or deactivate at the sub-second timescale. Few neuroimaging studies have addressed how Alzheimer’s disease (AD) affects these fast temporal brain dynamics, and how they relate to the cognitive, structural and metabolic abnormalities characte...
This magnetoencephalography study aimed at characterizing age-related changes in resting-state functional brain organization from mid-childhood to late adulthood. We investigated neuromagnetic brain activity at rest in 105 participants divided into three age groups: children (6-9 years), young adults (18-34 years) and healthy elders (53-78 years)....
Functional magnetic resonance imaging (fMRI) allowed the spatial characterization of the resting-state verbal language network (vLN). While other resting-state networks (RSNs) were matched with their electrophysiological equivalents at rest and could be spectrally defined, such correspondence is lacking for the vLN. This magnetoencephalography (MEG...
Human brain activity is not merely responsive to environmental context but includes intrinsic dynamics, as suggested by the discovery of functionally meaningful neural networks at rest, i.e., even without explicit engagement of the corresponding function. Yet, the neurophysiological coupling mechanisms distinguishing intrinsic (i.e., task-invariant...
Targeted Memory Reactivation (TMR) and transcranial Direct Current Stimulation (tDCS) can enhance memory consolidation. It is currently unknown whether TMR reinforced by simultaneous tDCS has superior efficacy. In this study, we investigated the complementary effect of TMR and bilateral tDCS on the consolidation of emotionally neutral and negative...
Recent advances shifted the focus on single-brain functioning toward two-brain communication during learning interactions, following the demonstration that interpersonal brain synchronization (IBS) can track instructor-learner information exchange. Here, we investigated (i) whether sleep deprivation (SD) that potentially impacts both social interac...
REM sleep is a peculiar neural state that occupies 20-25 percent of nighttime sleep in healthy human adults and seems to play critical roles in a variety of functions spanning from basic physiological mechanisms to complex cognitive processes. REM sleep exhibits a plethora of transient neurophysiological features, such as eye movements, muscle twit...
Attention-deficit/hyperactivity (ADHD) and autism spectrum (ASD) disorders often co-occur. In both cases, response inhibition deficits and inhibition-related atypical brain activation have been reported, although less consistently in ASD. Research exploring the overlap/distinctiveness between ADHD and ASD has significantly increased in recent years...
Functional near-infrared spectroscopy (fNIRS) is an optical diffusion technique that allows the non-invasive imaging of cortical activity. During the last two decades, rapid technical and methodological advances have made fNIRS a powerful tool to investigate the cerebral correlates of human performance and cognitive functions, including fatigue, sl...
Background:
Iron deficiency is the most prevalent micronutrient deficiency worldwide. There is evidence that iron deficiency produces alterations in the developing brain, eventually leading to long-lasting effects on various cognitive functions.
Methods:
Here, we investigated motor learning and its consolidation after sleep in adolescents who su...
Introduction: In a functional near-infrared spectroscopy (fNIRS)-based hyperscanning study (i.e. measuring cortical activities simultaneously in two brains), we previously showed that inter-brain synchrony (IBS) can track learning interactions within an instructor-learner dyad (Pan et al., 2018). In the present study, we tested whether sleep depriv...
The default-mode network (DMN) and its principal core hubs in the posterior midline cortices (PMC), i.e., the precuneus and the posterior cingulate cortex, play a critical role in the human brain structural and functional architecture. Because of their centrality, they are affected by a wide spectrum of brain disorders, e.g., Alzheimer's disease. N...
The human brain is functionally organized into large-scale neural networks that are dynamically interconnected. Multiple short-lived states of resting-state functional connectivity (rsFC) identified transiently synchronized networks and cross-network integration. However, little is known about the way brain couplings covary as rsFC states wax and w...
Sleep disturbances and anxiety disorders exhibit high comorbidity levels, but it remains unclear whether sleep problems are causes or consequences of increased anxiety. To experimentally probe the aetiological role of sleep disturbances in anxiety, we investigated in healthy participants how total sleep deprivation influences fear expression in a c...
How sleep interacts with interactive learning mechanisms remains obscure. We
investigated whether and how sleep deprivation (SD), that potentially impacts both
social interactions and learning abilities, modulates interpersonal brain
synchronization (IBS) during learning. Using functional NIRS, brain activity was
simultaneously recorded in sleep re...
Sleep disturbances are frequent and varied in autism spectrum disorder (ASD). Growing evidence suggests that sleep problems in children with ASD are driven by their clinical characteristics and psychiatric comorbidities. Therefore, the wide range of reported sleep disturbances reflects the marked heterogeneity of clinical pictures in ASD. Whether s...
Fatigue induced by sustained cognitive demands often entails decreased behavioural performance and the unavailability of brain resources, either due to reduced levels or impaired access. In the present study, we investigated the neural dynamics underlying preserved behavioural performance after inducing cognitive fatigue (CF) in a sleep deprivation...
Objectif
Dans quelle mesure l’architecture du sommeil joue un rôle dans la consolidation mnésique reste débattu : chaque stade de sommeil joue-t-il un rôle indépendant, ou la séquence ordonnée sommeil lent (SL) - sommeil paradoxal (SP) est-elle déterminante (hypothèse séquentielle) ?
Méthodes
Cinquante-quatre patients atteints de narcolepsie et d’...
