Philipp Rein’s research while affiliated with Kantonsspital St. Gallen and other places

... 11 Patients with both diabetes and CKD are at higher risk of cardiovascular morbidities and mortality, kidney failure, and death when compared with those without CKD. 12,13 Ethiopia is facing a double burden from communicable and noncommunicable diseases. Noncommunicable diseases and injuries account for 52% of the total mortality in 2016 in Ethiopia. ...

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Prevalence of Chronic Kidney Disease and Associated Factors among Patients with Diabetes in Northwest Ethiopia: A Hospital-Based Cross-Sectional Study

... Targeted synthetic tsDMARDs, including JAK inhibitors, act by blocking intracellular signaling pathways to control inflammation. 3 On the other hand, treatment options are determined according to the conditions of each country. In Turkey, while csDMARDs are recommended in the first phase, advanced therapies can be used without sequencing in case of ineffectiveness or intolerance. ...

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From Conventional to Advanced Therapies: A National Health Registry Report (2016-2022) on DMARDs in Rheumatoid Arthritis Treatment in Turkey

... In this study, levels of maltose, lactose and sucrose were increased in the FLHS group. Glucose metabolism was found to be up-regulated in the liver of mice or human with NAFLD (Saely et al., 2017;Lu et al., 2020). Moreover, fasting glucose concentrations were also significantly elevated in the layers fed with high-energy low-protein diet (Zhuang et al., 2019). ...

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Untargeted and targeted metabolomics profiling reveals the underlying pathogenesis and abnormal arachidonic acid metabolism in laying hens with fatty liver hemorrhagic syndrome

... Only few studies have also looked at this question assessing uromodulin in urine, but with contradictory results. One study showed that the serum uromodulin is significantly associated with impaired glucose metabolism and the development of diabetes (Leiherer et al, 2017). Other study concluded that serum uromodulin concentrations are closely correlated with estimated Glomerular Filtration Rate, which is the recommended measure of renal function (Steubl et al, 2016). ...

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CLINICAL AND BIOCHEMICAL ASSOCIATION BETWEEN SERUM AND URINE LEVEL OF THE UROMODULIN PROTEIN WITH ALBUMINURIA IN PATIENTS WITH TYPE-2 DIABETES MELLITUS

... (22) Desde el enfoque comunitario, se hace necesario el fortalecimiento de los programas de Atención Primaria de Salud (APS), con énfasis en el retardo del daño renal, se debe tener presente que la tasa de filtrado glomerular, puede disminuir por tres causas principales: pérdida del número de nefronas con daño al tejido renal; disminución sin descenso en el número total de nefronas; y por procesos combinados con pérdida del número y disminución de la función. (23) La ERC es una problemática de salud que potencializa la importancia del trabajo interdisciplinario, la contribución social con respecto a la participación de las personas sobre el cuidado de su propia salud, la institucionalización de programas preventivos y un mayor nivel de cooperación entre el equipo de salud para la prevención y retardo de la ERC, son imperativos. (23) Debe tenerse en cuenta el papel que juega el primer nivel de atención en el tratamiento de pacientes crónicos porque al ser el primer contacto de atención genera la responsabilidad de educar al paciente y crearle conciencia de la importancia del adecuado control y de cumplir al pie de la letra las medidas generales con el propósito de evitar la evolución de la ERC, o en su caso retardar, la aparición de complicaciones propias de su enfermedad. ...

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Characteristics of patients with chronic kidney disease belonging to a health area in Las Tunas

... As TRLs are cholesterol-rich, RC has attracted attention for its pathogenic capability due to a recently proposed concept-that of cholesterol toxicity-and this has engendered novel perspectives on the development of DM [34]. Previous cohort studies of the general population and coronary artery disease patients suggested that RC was a predictor of new-onset hyperglycemia, superior to other traditional lipid parameters [17,18,35]. Another study conducted in a kidney transplant cohort also demonstrated a significant association of baseline RC with new onset diabetes after transplantation [36]. ...

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The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus

... Alanine aminotransferase (ALT) is mainly found in hepatocytes, while aspartate aminotransferase (AST) mainly exists in the myocardium, followed by liver, kidney, and other tissues (Smith et al., 2020). Generally, the content of serum AST is low, but AST will be released into the blood when cells are injured, thus, AST is often used as a serum enzyme index for the diagnosis of liver injury (Vonbank et al., 2015;Li, 2020). Determination of serum ALT, AST, TG, and other indexes is FIGURE 4 | Isoorientin can reduce the oxidative damage of cells induced by oleic acid. ...

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Protective Effect of Isoorientin on Oleic Acid-Induced Oxidative Damage and Steatosis in Rat Liver Cells

... Thus far, there is no report that indicates a direct correlation between BMI and Lp(a). However, some studies indicated a negative correlation between metabolic syndrome and serum Lp(a), and several prospective cohort studies reported that individuals with metabolic syndrome have significantly lower Lp(a) levels than those without metabolic syndrome [30][31][32] . ...

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Association of Renal Function and Statin Therapy with Lipoprotein(a) in Patients with Type 2 Diabetes

... They also offer a favorable safety profile, making them ideal for patient's intolerant to statins [73]. trials [91]. Existing literature suggests the role of ApoB in individuals with low HDL-c, a history of ASCVD, T2DM, and hypertriglyceridemia for cardiovascular risk stratification [88,92]. ...

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Cardiovascular Risk Factor and Atherosclerosis in Rheumatoid Arthritis (RA)

... Previous studies showed the association of hand grip strength with heart failure and cardiovascular risks such as high blood pressure, high blood sugar and lipid levels [51,52]. Hand grip strength in patients with type 2 diabetes is inversely associated with CVD independently from well-established cardiovascular risks [53]. A prospective study from the UK also showed hand grip strength has inverse associations with incidence of cardiovascular events [54]. ...

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Socioeconomic and behavioral determinants of cardiovascular diseases among older adults in Belgium and France: A longitudinal analysis from the SHARE study