Philip Blair's scientific contributions

Publications (12)

Chapter
Autism spectrum disorder (ASD) is a complex behavioral condition that is characterized by deficits in communication and social interaction, stereotypic or repetitive behaviors, restricted patterns of interest, and sensory issues including extreme responses. It begins in early childhood and extends throughout life. It is associated with several como...
Chapter
Anxiety is a common condition for which people have been found to self-medicate with cannabis. Anxiety is often comorbid with other conditions, including depression, sleep disorders and chronic pain. The pathomechanisms underpinning anxiety are complex. Animal and human research indicates that the endocannabinoid system is involved in our stress re...
Chapter
Good sleep is vital for good health, and poor sleep, in particular insomnia, is associated with a range of poor health outcomes. Sleep disorders are common and a key reason why people self-medicate with cannabis. We have two key biological mechanisms which work together to regulate our sleep-wake cycle, the processes of sleep-wake homeostasis and o...
Chapter
The endocannabinoid system (ECS) was discovered in the early 1990s and is one of the most important neuroregulatory systems in the body. The ECS is responsible for homeostasis of most systems in the body. At a simplistic level, it is composed of endogenous ligands called endocannabinoids, cannabinoid receptors (CB1 and CB2 receptors), and enzymes t...
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Dementia is a group of diseases characterized by gradual impairment of brain function. Alzheimer’s disease is the most common form of dementia and is characterized by many neuropsychiatric symptoms, of which loss of memory is only one and possibly not the most problematic. The pathophysiology of Alzheimer’s disease involves a triad of neuroinflamma...
Chapter
Psychosocial stress, in particular chronic stress, has emerged as a key factor in the pathophysiology of many chronic diseases, including mental health conditions. Stress is anything that challenges our homeostasis. Several brain regions are involved in stress regulation including the corticolimbic system and the hypothalamic-pituitary-adrenal (HPA...
Chapter
There are four main routes of administration of medicinal cannabis: inhalation, the oral route, topical applications and ‘other routes’ (eg. suppositories, intranasal delivery). Each is associated with different onsets of action and durations of action due to their pharmacokinetic profiles. There are some safety issues associated with cannabis. Man...
Chapter
Post-traumatic stress disorder (PTSD) is a debilitating mental illness that can result from exposure to a life-threatening or traumatic event. It has been described as an anxiety disorder, a disorder of dysregulation of fear and processing of stimuli associated with trauma, and a paradoxical disorder of memory. There is evidence that the endocannab...

Citations

... THC is responsible for the potentially intoxicating effects associated with cannabis (the potential for causing intoxication, i.e., the euphoria or 'high' associated with cannabis, is dose-dependent), but unlike THC, CBD is not potentially intoxicating and not associated with the typical symptoms associated with cannabis intoxication [13,17], making it perhaps more attractive as a treatment option. Both THC and CBD have many therapeutic actions in common, but their mechanisms of action differ [9]. THC is a partial agonist of the CB1 and CB2 receptors, similar to AEA [18]. ...