Peter W Hashim's research while affiliated with Icahn School of Medicine at Mount Sinai and other places

Publications (37)

Article
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Alopecia areata/AA is an autoimmune cause of nonscarring hair loss. The pathogenesis of AA involves many immune axes, including Th1/Th2 pathways. Delgocitinib is a pan-Janus kinase/JAK inhibitor that broadly blocks pro-inflammatory cytokines and has been effective in other inflammatory skin conditions. Recent human studies/reports have shown that u...
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To the Editor: Cutaneous warts are seen in as many as a quarter of immunosuppressed patients. 1 Cell-mediated immunodeficiency, as seen in HIV, is correlated with increased rates of palmoplantar warts. 2 These warts often cause discomfort, and can progress to verrucous carcinoma. As they can be resistant to traditional treatments like cryotherapy,...
Article
OBJECTIVE: Despite common administration of intralesional triamcinolone to acne lesions, there is little published data or consensus on best practices. This study aimed to evaluate specific characteristics of intralesional triamcinolone for acne among various dermatology healthcare professionals. DESIGN: One hundred participants (82 attending physi...
Article
Context: Skin sensitivity may be best defined as self-reported intolerance to application of skincare products. It is commonly believed that individuals with darker skin are generally less sensitive, while those lighter skin are more sensitive. However, there is little objective data correlating sensitivity with skin type or with objective measures...
Article
Capsule summary: In a clinical trial of moderate-to-severe atopic dermatitis/AD patients treated with anti IL-17mAb/secukinumab, no significant clinical or molecular improvements were seen, even among disease subtypes with high Th-17-skewing (intrinsic/Asian AD).
Article
IMPORTANCE: There are increasing options for systemic combination therapy for psoriasis but a lack of literature around the characteristics of patients who are started on these regimens. OBJECTIVE: We aimed to determine how combination systemic therapy patients differ from monotherapy patients in their social, medical, or treatment history. DESIG...
Article
Background: Psoriasis of the intertriginous, anogenital, and facial regions remains a therapeutic challenge, with current algorithms lacking a topical agent that exhibits both high efficacy and minimal side effects. Objective: To assess the safety and efficacy of crisaborole 2% ointment-a nonsteroidal phosphodiesterase 4 inhibitor-in the treatme...
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Psoriasis is an inflammatory skin disease that is associated with many comorbidities. Several psoriasis treatments approved by the United States Food and Drug Administration have been shown to have beneficial effects on these comorbidities, while others might lead to an exacerbation of these conditions. In this article, we review studies of psorias...
Article
Actinic keratosis (AK) develops on chronically sun-exposed skin and constitutes one of the most common diseases managed by dermatologists. The incidence of AKs continues to rise among aging as well as younger sun damaged populations worldwide, underscoring the importance of effective therapy options. Various treatments are available, including ligh...
Article
Nanotechnology is an emerging branch of science that involves the engineering of functional systems on the nanoscale (1-100 nm). Nanotechnology has been used in biomedical and therapeutic agents with the aim of providing novel treatment solutions where small molecule size may be beneficial for modulation of biologic function. Recent investigation i...
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Atopic dermatitis affects up to 20% of children and continues to increase in prevalence. Effective disease control is aimed at decreasing symptoms and reducing the frequency of flares, which may be complicated by secondary bacterial infections. Although recent advances have produced a number of non-systemic treatment options, topical corticosteroid...
Article
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Alopecia areata (AA) is a common autoimmune disease that results in non-scarring hair loss. AA pathogenesis is thought to involve multiple inflammatory cytokines. Apremilast is a phosphodiesterase 4 (PDE4) inhibitor that reduces pro-inflammatory cytokine production. Recent studies demonstrate upregulation of PDE4 in human scalp lesions of AA patien...
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Introduction: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, has demonstrated superior efficacy to ustekinumab in the phase 3b CLEAR study of moderate to severe plaque psoriasis. Here, we report 16-week results from CLARITY, a second head-to-head trial comparing secukinumab with ustekinumab. Methods: In the phase 3b CLARITY...
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Alopecia areata (AA) is a common form of non-scarring hair loss. The pathogenesis of AA is believed to involve multiple inflammatory cytokines, including possibly IL-17A. To assess the efficacy and safety of the IL-17A antagonist secukinumab in AA, we conducted a double-blinded, randomized prospective pilot study in which 11 subjects were treated w...
Article
Brodalumab, a fully human antibody of the interleukin-17 receptor, is highly effective in the treatment of moderate-to-severe plaque psoriasis. However, based on safety signals identified in clinical trials, brodalumab carries a boxed warning regarding possible risks of suicidal ideation and behavior (SIB). The validity of this link remains controv...
Article
This study expands the current paradigm on AA cytokine profile in serum and scalp, identifying IL-15, and Th1 and Th2 serum cytokines that reflect both tissue activity and clinical disease severity.
Article
Acne vulgaris and postacne scarring are common in the general population. Even after lesions have resolved, scarring can lead to detrimental psychologic effects and can negatively impact patients' quality of life. Fortunately, there have been several recent advances in therapeutic options to treat acne scarring. This article discusses these treatme...
Article
Background: Azelaic acid demonstrates anti-inflammatory, anti-oxidative, anti-comedogenic, and anti-microbial effects. Azelaic acid 20% cream is currently approved for the treatment of acne vulgaris, and azelaic acid 15% foam has recently been approved for rosacea. Given the favorable tolerability profile of foam preparations, it is reasonable to...
Article
Noninvasive body contouring is the fastest growing area of cosmetic dermatology. It entails the use of specific technology to optimize the definition, smoothness, and shape of the human body in a safe and effective manner. There are currently 4 leading modalities used for noninvasive body contouring: cryolipolysis, radiofrequency, highintensity foc...
Chapter
Biologic agents are a relatively new class of medication that typically target specific parts of the immune system. These medications were originally developed for use in a variety of autoimmune and inflammatory conditions, for which they have had great success in treatment. In recent years, biologics have been tested as off-label treatments for a...
Article
Stem cell therapies are at the forefront of regenerative aesthetic medicine. Multipotent stem cells and induced pluripotent stem cells (iPSCs), progenitor cells that result from the dedifferentiation of specialized adult cells, have demonstrated promise in tissue regeneration for a wide range of dermatologic conditions and aesthetic applications. H...
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Background: Characterizing blood profile of alopecia areata (AA) is not only important for treatment advancements, but also for possibly identifying peripheral biomarkers that will eliminate the need for scalp biopsies. We aimed to compare frequencies of skin homing (CLA(+) ) vs. systemic (CLA(-) ) "polar" CD4(+) and CD8(+) and activated T-cell su...
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Facial aesthetic procedures are central to cosmetic dermatology. Success depends not only on improving individual structures but also on establishing facial harmony. Several canons of aesthetic dimensions have been described, and these concepts can provide a useful basis for procedural planning. Here, we review aesthetic facial measurements and pro...
Article
BACKGROUND: Topical corticosteroids are known to impair the epidermal barrier, even after short-term use, whereas topical vitamin D analogues can have a reparative effect. Combination products using corticosteroids and vitamin D analogues have gained popularity in recent years and may provide a means to minimize skin atrophy in patients treated wit...
Article
Topical cannabinoids are increasingly utilized by dermatology patients for a range of disorders; however, the acceptance of these over-the-counter products has far outpaced scientific investigation into their safety and efficacy. Here, we review the studies of topical cannabinoids in skin conditions and assess their current place in dermatology pra...
Article
Local anesthetics play an important role in cosmetic dermatology. Techniques using topical and regional anesthesia provide numerous pain management options for laser and injection treatments. In this article, we review strategies to maximize patient comfort during cosmetic interventions.
Article
p>Background: Ingenol mebutate gel 0.015% provides high clearance rates for actinic keratosis (AK) on the face and scalp but causes transient local skin responses (LSRs). Objective: This study sought to determine whether the application of 1% dimethicone would decrease ingenol mebutate-associated LSRs and/or affect efficacy during the treatment of...
Article
Microneedling therapy is an increasingly popular treatment of several dermatologic conditions. Platelet-rich plasma (PRP) may serve as a valuable adjunct to improve the regenerative effects of treatment. We review the evidence comparing the results of microneedling therapy with and without PRP. Based on the current preliminary literature, PRP appea...
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Purpose of Review This review will highlight the latest data on ustekinumab, as well as provide anecdotal evidence and insight into unanswered questions regarding its safety and the populations’ best suited for its use. Recent Findings In numerous clinical trials, ustekinumab has been found to be safe and efficacious. Many targeted psoriasis medic...
Article
Inverse psoriasis, also known as intertriginous or flexural psoriasis, remains a challenging condition to treat. For decades, the mainstay therapy approach has been low-potency steroids for short durations due to the risk of cutaneous atrophy and striae. Other topical options include immunomodulators, vitamin D analogues, and tar-based products. In...
Article
Late-stage melanoma is associated with high morbidity and mortality. Classic treatment methods relied on cytotoxic chemotherapy, which is limited by low response rates and significant adverse effects. Recent advances in immunogenetics have led to the advent of important new systemic treatments. This article reviews the latest therapy options for ad...
Article
Full-text available
Objectives: To evaluate the safety and efficacy of ingenol mebutate 0.05% gel after cryosurgery versus cryosurgery alone for the treatment of hypertrophic and nonhypertrophic actinic keratosis on the dorsal hands. Design: Investigator-blinded split arm study. Setting: Academic institution. Participants: Sixteen subjects with actinic keratose...

Citations

... Baricitinib, 1, 2 or 4 mg daily, was investigated in 2 studies (27,20). Topical delgocitinib was investigated by 1 study, where the dose was 30 mg/g twice daily (21). Oral ritlecitinib (initially 200 mg once daily and subsequently 50 mg once daily) and brepocitinib (initially 60 mg once daily and subsequently 30 mg once daily) were investigated in 2 studies (22,26). ...
... However, it must be performed by medical personnel and is less accepted by patients due to pain and needle phobia. Furthermore, ILS is an operatordependent procedure that needs skilled personnel to deliver effective treatment, and side effects such as skin atrophy, hypopigmentation, and infection can occur after treatment [7][8][9]. ...
... Globally, as much as 71% of the general adult population reports having sensitive skin to some degree, while 40% individuals report having moderate or very sensitive skin [6]. Patient's self-perception of skin sensitivity has been found as a likely indicator of true sensitivity measured instrumentally, and it may occur with similar prevalence across all Fitzpatrick skin types [7]. Epidemiological studies have also shown that these symptoms are more frequent on the face, where the skin is more exposed and nerve density is higher [8]. ...
... Placebo and treatment arm showed no difference in markers of epidermal thickness and hyperplasia, or clinical outcomes, such as SCORAD and EASI at 16 weeks, even when subjects were stratified into intrinsic and extrinsic AD, given intrinsic AD subtype has been found to exhibit skewed Th17 expression (Table 2). 160 ...
... In contrast, an analysis of National Ambulatory Medical Care Survey data from 2003 to 2016 found that Latino patients with psoriasis in the US were significantly more likely to be treated with biologics than non-Latino patients [35]. In terms of other types of psoriasis therapies, some single-center and registry-based observational studies suggest that Black patients are more likely to receive combination therapy (i.e., biologic and non-biologic systemic therapy; based on registry data from centers in the US and Canada) [36], non-biologic systemic therapy (for patients at an academic center in Missouri) [23], and topical therapy [23] than non-Black patients. These findings of different trends among groups of people with psoriasis and SoC compared with white patients highlight the importance of considering different ethnic/racial groups individually as opposed to grouping together non-white patient populations. ...
... Psoriatic patients have an increased risk of CVD; furthermore, this risk increases with the patient's age and increases the number of co-medications used for the treatment of CV comorbidities. Current evidence supports the protective role of MTX in CVD [23,[27][28][29]. Moreover, drug interactions are not common with MTX, with the exception of trimethoprim-sulfamethoxazole and high-dose acetylsalicylic acid, which can exacerbate MTX toxicity [4,30]. ...
... Crisaborole 2% ointment is a safe and effec�ve nonsteroidal treatment op�on for facial psoriasis. 31 Apremilast, cyclosporine, low-dose re�noid, and methotrexate are commonly used when topical treatment fails. More recently, biologic therapies have become the mainstay for the treatment of moderate to severe plaque psoriasis, despite their high cost and need for subcutaneous administra-�on. ...
... Non-melanoma skin cancer (NMSC) includes basal cell cancer, squamous cell carcinoma, and actinic keratosis (AKs). The latter can transform into invasive squamous cell carcinoma between 0.025% and 16% of cases [64]. Nowadays, many treatments are available for AKs, including cryotherapy, topical chemotherapy, and photodynamic therapy (PDT). ...
... Recently, it has been reported that nanoparticles solution itself can act as tissue adhesive for hydrogels and biological tissues [9]. Based on nano-bridging effect, nanoparticles that are adsorbed onto tissue surfaces act as connectors between tissues and assure adhesion [10,11]. And they have been regarded as new strategies to facilitate tissue repair and regeneration. ...
... Among the standard dosage forms, ointments are based on fluid and/or solid oils, commonly white soft petrolatum, often combined with an aggressive solvent such as propylene glycol. Ointments generally offer high diffusion of active ingredients through the skin barrier [9] and immediate hydration by decreasing trans-epidermal water loss [10]. However, even assuming a low frequency of adverse reactions, many patients are averse to ointments on aesthetic grounds because of the difficulty rubbing in the medication and issues with the medication's greasiness and the medication sticking to clothes [11]. ...