Peter Stehle’s research while affiliated with University of Bonn and other places

... Obesity is a major public health concern affecting 1 billion adults and children worldwide. 1 In parallel, there is a growing burden of cancer globally; in 2020 more than 19 million people were diagnosed with cancer, and this figure is projected to increase to more than 30 million new cases per year by 2040. 2 Obesity is now recognised as an important cause of some cancers. Based on a 2016 evaluation by the International Agency for Research on Cancer (IARC), obesity was established as a cause of cancers of the breast (postmenopausal), colorectum, endometrium, ovary, kidney, liver, gallbladder, gastric cardia, oesophagus (adenocarcinoma), thyroid and pancreas as well as for multiple myeloma and meningioma. ...

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Is obesity a cause of all cancer types?

... Unlike probiotics or prebiotics, the synbiotics enhance the survival and activity of beneficial bacteria synergistically, thereby improving colonizing and growth of beneficial microbes in gut (116). Synbiotics have also been utilized to stimulate microbiota growth while increasing neuroprotective metabolites production such as SCFAs and butyrate (117). Research has shown that synbiotics administration in PD significantly reduces oxidative stress and neuroinflammation by influencing metabolic pathways of the gut microbiome (118). ...

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Microbiome-based therapies for Parkinson’s disease

... Synbiotics are combinations of live microorganisms and substrates that confer a benefit to host health with potentially synergistic effects 68 . Although a 7-week synbiotic intervention revealed improvement in ALT in metabolically healthy individuals, a one-year randomized controlled trial evaluating synbiotics in patients with MASLD did not reveal significant improvements in hepatic steatosis or fibrosis 69,70 . ...

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Microbiome-Centered Therapies for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease

... Obesity is a major public health challenge, and its global incidence has been increasing for decades [1,2]. This increase has been driven by urbanization, sedentary lifestyles, inadequate sleep, and high-calorie processed foods [3]. ...

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Body Composition Trend in Slovene Adults: A Two-Year Follow-Up

... This information was analyzed using genetic risk scores (GRSs), which combined several single-nucleotide polymorphisms (SNPs) by summing the number of risk alleles, and it was found that male adolescents with high adherence to the MD and fewer genetic risk alleles had lower DBP. Following this approach, in a recent study involving 548 adolescents from the HELENA cohort (53% female), researchers examined the impact of an MD score and a genetic risk score for hypertension (HTN-GRS) based on 16 single-nucleotide polymorphisms (SNPs) associated with HTN [27]. The results showed that adherence to the MD had a protective effect on both systolic and DBP z-scores. ...

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Dietary Strategies in the Prevention and Treatment of Hypertension in Children and Adolescents: A Narrative Review

... In a recent validation study, the PHDI showed its efficacy in assessing usual nutrient intakes, food consumption biomarkers, and adherence to the Mediterranean diet in European adolescents, yielding satisfactory results and showcasing its applicability for use in teenagers [7]. Furthermore, higher PHDI scores were associated with better cardiovascular health in European adolescents [8]. ...

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How to improve sustainability of nutrient dense diets for children and adolescents: an exemplary assessment in Germany

... The OGTT primarily assesses fasting plasma glucose (FPG) and 2 h postprandial plasma glucose levels [5]. However, the disadvantage of OGTT was a low response rate [6], and several studies indicated that relying solely on FPG might underestimates the prevalence of diabetes in low-and middle-income countries [7]. Therefore, it was particularly essential to identify more sensitive biomarkers for diabetes and implement proactive measures such as lifestyle interventions. ...

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Alterations in the Levels of Urinary Exosomal MicroRNA-183-5p and MicroRNA-125a-5p in Individuals with Type 2 Diabetes Mellitus

... The microglial-modulating drug minocycline has been shown to increase plasma NfL concentration severalfold [110], establishing the possibility of conflating these increases with those linked to AD pathogenesis. A separate drug, the anti-heart failure medication neprilysin, decreased plasma Aβ42/Aβ40 levels by nearly 30% [111]. Nutritional plans also play a role, wherein standardized meals have been shown to reduce NfL, GFAP, and P-tau 181 and 231 by up to 20% within hours [112], unintentionally impacting lab results and leading to the possibility of misdiagnosing or mis-staging of the disease. ...

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Navigating the Alzheimer’s Biomarker Landscape: A Comprehensive Analysis of Fluid-Based Diagnostics

... Moreover, it has shown associations with health outcomes, including obesity indicators and cardiovascular risk markers [5,6]. In a recent validation study, the PHDI showed its efficacy in assessing usual nutrient intakes, food consumption biomarkers, and adherence to the Mediterranean diet in European adolescents, yielding satisfactory results and showcasing its applicability for use in teenagers [7]. Furthermore, higher PHDI scores were associated with better cardiovascular health in European adolescents [8]. ...

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How to improve sustainability of nutrient dense diets for children and adolescents: an exemplary assessment in Germany

... Indeed, ground-based analogue studies continue to complement spaceflight experiments [100][101][102][103][104][105][106][107] , providing valuable insights into human responses to the space environment. As space research advances, integrating data from individuals of diverse ages, sexes and lifestyles is essential to facilitate a comprehensive understanding of genetic and epigenetic associations with space adaptation. ...

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A Second Space Age Spanning Omics, Platforms, and Medicine Across Orbits