Peter Stehle’s research while affiliated with University of Bonn and other places

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Publications (262)


Figure 1: Distributions of BMI and waist-to-height ratio, by region The black lines below each distribution show the 2·5%, 25·0%, 75·0%, and 97·5% quantiles of the distributions and the points show the median. The dashed lines show medians across all participants. Regions are ordered by their sex-specific median BMI. See appendix (p 55) for numerical summaries.
Figure 3: Regional BMI adjustment The BMI adjustment shows how much lower BMI in each region should be to achieve an equivalent waist-toheight ratio. The adjustment is shown relative to the population of the high-income western region where most current epidemiological studies have been done; regional ordering and differences across regions would be unchanged if a different reference were used. The bars show 95% CIs of the BMI adjustments. See appendix (pp 90-91) for results using waist circumference.
General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants
  • Article
  • Full-text available

August 2024

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1,262 Reads

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3 Citations

The Lancet

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James E. Bennett

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Aidan P. Wickham

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Majid Ezzati

Background Adiposity can be measured using BMI (which is based on weight and height) as well as indices of abdominal adiposity. We examined the association between BMI and waist-to-height ratio (WHtR) within and across populations of different world regions and quantified how well these two metrics discriminate between people with and without hypertension.

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Citations (65)


... Obesity is a major public health concern affecting 1 billion adults and children worldwide. 1 In parallel, there is a growing burden of cancer globally; in 2020 more than 19 million people were diagnosed with cancer, and this figure is projected to increase to more than 30 million new cases per year by 2040. 2 Obesity is now recognised as an important cause of some cancers. Based on a 2016 evaluation by the International Agency for Research on Cancer (IARC), obesity was established as a cause of cancers of the breast (postmenopausal), colorectum, endometrium, ovary, kidney, liver, gallbladder, gastric cardia, oesophagus (adenocarcinoma), thyroid and pancreas as well as for multiple myeloma and meningioma. ...

Reference:

Is obesity a cause of all cancer types?
General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants

The Lancet

... Unlike probiotics or prebiotics, the synbiotics enhance the survival and activity of beneficial bacteria synergistically, thereby improving colonizing and growth of beneficial microbes in gut (116). Synbiotics have also been utilized to stimulate microbiota growth while increasing neuroprotective metabolites production such as SCFAs and butyrate (117). Research has shown that synbiotics administration in PD significantly reduces oxidative stress and neuroinflammation by influencing metabolic pathways of the gut microbiome (118). ...

Beneficial Effects of Synbiotics on the Gut Microbiome in Individuals with Low Fiber Intake: Secondary Analysis of a Double-Blind, Randomized Controlled Trial

... Synbiotics are combinations of live microorganisms and substrates that confer a benefit to host health with potentially synergistic effects 68 . Although a 7-week synbiotic intervention revealed improvement in ALT in metabolically healthy individuals, a one-year randomized controlled trial evaluating synbiotics in patients with MASLD did not reveal significant improvements in hepatic steatosis or fibrosis 69,70 . ...

Impact of Synbiotic Intake on Liver Metabolism in Metabolically Healthy Participants and Its Potential Preventive Effect on Metabolic-Dysfunction-Associated Fatty Liver Disease (MAFLD): A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial

... Obesity is a major public health challenge, and its global incidence has been increasing for decades [1,2]. This increase has been driven by urbanization, sedentary lifestyles, inadequate sleep, and high-calorie processed foods [3]. ...

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

The Lancet

... This information was analyzed using genetic risk scores (GRSs), which combined several single-nucleotide polymorphisms (SNPs) by summing the number of risk alleles, and it was found that male adolescents with high adherence to the MD and fewer genetic risk alleles had lower DBP. Following this approach, in a recent study involving 548 adolescents from the HELENA cohort (53% female), researchers examined the impact of an MD score and a genetic risk score for hypertension (HTN-GRS) based on 16 single-nucleotide polymorphisms (SNPs) associated with HTN [27]. The results showed that adherence to the MD had a protective effect on both systolic and DBP z-scores. ...

Interplay of the Mediterranean diet and genetic hypertension risk on blood pressure in European adolescents: Findings from the HELENA study

European Journal of Pediatrics

... In a recent validation study, the PHDI showed its efficacy in assessing usual nutrient intakes, food consumption biomarkers, and adherence to the Mediterranean diet in European adolescents, yielding satisfactory results and showcasing its applicability for use in teenagers [7]. Furthermore, higher PHDI scores were associated with better cardiovascular health in European adolescents [8]. ...

Association between adherence to the EAT-Lancet sustainable reference diet and cardiovascular health among European adolescents: the HELENA study

European Journal of Clinical Nutrition

... The OGTT primarily assesses fasting plasma glucose (FPG) and 2 h postprandial plasma glucose levels [5]. However, the disadvantage of OGTT was a low response rate [6], and several studies indicated that relying solely on FPG might underestimates the prevalence of diabetes in low-and middle-income countries [7]. Therefore, it was particularly essential to identify more sensitive biomarkers for diabetes and implement proactive measures such as lifestyle interventions. ...

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Nature Medicine

... The microglial-modulating drug minocycline has been shown to increase plasma NfL concentration severalfold [110], establishing the possibility of conflating these increases with those linked to AD pathogenesis. A separate drug, the anti-heart failure medication neprilysin, decreased plasma Aβ42/Aβ40 levels by nearly 30% [111]. Nutritional plans also play a role, wherein standardized meals have been shown to reduce NfL, GFAP, and P-tau 181 and 231 by up to 20% within hours [112], unintentionally impacting lab results and leading to the possibility of misdiagnosing or mis-staging of the disease. ...

Levels of Alzheimer's disease blood biomarkers are altered after food intake-A pilot intervention study in healthy adults
  • Citing Article
  • May 2023

... Moreover, it has shown associations with health outcomes, including obesity indicators and cardiovascular risk markers [5,6]. In a recent validation study, the PHDI showed its efficacy in assessing usual nutrient intakes, food consumption biomarkers, and adherence to the Mediterranean diet in European adolescents, yielding satisfactory results and showcasing its applicability for use in teenagers [7]. Furthermore, higher PHDI scores were associated with better cardiovascular health in European adolescents [8]. ...

Relative validity of the Planetary Health Diet Index by comparison with usual nutrient intakes, plasma food consumption biomarkers, and adherence to the Mediterranean diet among European adolescents: the HELENA study

European Journal of Nutrition

... Indeed, ground-based analogue studies continue to complement spaceflight experiments [100][101][102][103][104][105][106][107] , providing valuable insights into human responses to the space environment. As space research advances, integrating data from individuals of diverse ages, sexes and lifestyles is essential to facilitate a comprehensive understanding of genetic and epigenetic associations with space adaptation. ...

Effects of antioxidant supplementation on bone mineral density, bone mineral content and bone structure in healthy men during 60 days of 6° head-down tilt bed rest: Results from a randomised controlled trial
  • Citing Article
  • April 2023

Nutrition Bulletin