Peter Husslein's research while affiliated with University of Vienna and other places

Publications (42)

Chapter
Aufgrund verschiedener Gründe, allen voran aufgrund des steigenden mütterlichen Alters und einer entsprechenden Zunahme an Risikoschwangerschaften, ist die Prävalenz der Geburtseinleitung in den letzten 20 Jahren deutlich angestiegen und hat mittlerweile über 20 % laller Schwangerschaften erreicht. Ziel dieser Intervention ist ein besseres perinata...
Chapter
Jede Geburtseinleitung bedarf einer Indikation, die besonders bei unreifer Zervix streng zu stellen ist. Oxytozin wird als kontrollierte intravenöse Infusion bei reifer Zervix, vor allem bei klarer medizinischer Indikation angewendet; Prostaglandine können endozervikal und intravaginal als Gel oder Tabletten in unterschiedlicher Dosierung sowohl be...
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To evaluate whether a screening strategy in pregnancy lowers the rate of preterm delivery in a general population of pregnant women. Multicentre, prospective, randomised controlled trial. Non-hospital based antenatal clinics. 4429 pregnant women presenting for their routine prenatal visits early in the second trimester were screened by Gram stain f...
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Objective:To evaluate the effect of a dedicated monitoring protocol on the incidence of pregnancy-induced hypertension disorders (preeclampsia, HELLP [hemolysis, elevated liver enzymes, low platelets] syndrome, gestational hypertension) during a 5-year period in 417 women with multiple gestations.
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We studied the production of cytokines in purified cultures of human term trophoblasts in the presence of pathogenic strains of Escherichia coli, Bacteroides fragilis, Mycoplasma hominis, Staphylococcus aureus, and Streptococcus agalactiae, which have been identified in intrauterine infections. Human villous trophoblasts were isolated from term pla...
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A higher prevalence of risk factors for venous thromboembolism (VTE) has been found in women with preeclampsia and fetal loss. We investigated whether women with a history of VTE have a higher prevalence of pregnancy-associated complications compared with control subjects. In 395 patients with a history of VTE and in 313 control women, the prevalen...
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We conducted a prospective study at the Department of Obstetrics and Gynecology, University Hospital of Vienna to investigate associations between serum testosterone levels and maternal peripartal mood states. Two hundred and fifty-two pregnant women at term (38 to 40 weeks' gestation) took part in the study. Blood samples for plasma testosterone l...
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To test the hypothesis that serum levels of basic fibroblast growth factor (bFGF) are altered among women with pregnancy-induced hypertension (PIH) and are associated with disease severity. We evaluated serum levels of bFGF in 46 women with PIH, 46 age- and parity-matched healthy pregnant women, and 46 healthy nonpregnant controls. Enzyme-linked im...
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Differentiation of primary villous cytotrophoblasts into syncytia is associated with increasing production of alpha and beta human CG subunits, which is predominantly governed at the level of messenger RNA expression. Here, we present a detailed study on the mechanisms involved in the differentiation-dependent regulation of the trophoblast-specific...
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The purpose of this study was to determine the effect of maternal pre-pregnancy body mass index (BMI) and maternal smoking habits on neonatal birth weight. We reviewed 10,240 normal singleton term pregnancies between 1985 and 1995 at the University Department of Obstetrics and Gynecology, Vienna. Birth weights of infants of overweight smokers were...
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Preeclampsia is still a leading cause of maternal and fetal morbidity and mortality. There is evidence for the involvement of platelets. Therefore, we investigated the suitability of corrected whole blood impedance aggregometry as an early predictor of preeclampsia in 71 consecutive, high-risk pregnancies. According to the occurrence of preeclampsi...
Article
Accurately predicting the onset of delivery continues to be problematic notwithstanding the clinical relevance of this capability, especially with regard to the elective induction of labor. While the assessment of the cervix according to Bishop, to date, constitutes the single generally recognized method, the determination of fetal fibronectin (FFN...
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The purpose of this study was to determine the effect of maternal pre-pregnancy body mass index (BMI) and maternal smoking habits on neonatal birth weight. We reviewed 10,240 normal singleton term pregnancies between 1985 and 1995 at the University Department of Obstetrics and Gynecology, Vienna. Birth weights of infants of overweight smokers were...
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We performed a systematic review to evaluate endovaginal cervical ultrasonography as a predictor of preterm delivery. Selection criteria were original published English-language reports of prospective studies including women at <37 weeks' gestation with intact amniotic membranes. Parameters and outcomes were cervical length or dilatation of the int...
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The aim of the survey was to determine the contraceptive behavior and knowledge on contraceptive methods of adolescents. We defined six clusters according to personality, leisure activities, and sociodemographic characteristics: conventionalists, careerists, idealists, bouncers, desperadoes, and outsiders. 1010 Austrian adolescents aged 14-24 years...
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The mechanisms that ultimately regulate cervical ripening during parturition remain largely unknown. A possible role for nitric oxide (NO) has recently emerged; however, the expression of NO synthase (NOS) within the human cervix in the ripening process has not been investigated. The purpose of this study was to identify cell types in the human cer...
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Our purpose was to compare concentrations of messenger ribonucleic acid specific for the oxytocin receptor and for the vasopressin 1a receptor in myometrial and endometrial tissues of pregnant and nonpregnant women. Tissues from pregnant uteri were obtained from 95 women who were undergoing cesarean delivery between 26 and 42 weeks' gestation. Tiss...
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The basic helix-loop-helix (bHLH) factor Hand1 plays a role in the developing chicken heart and is required for trophoblast giant cell differentiation and cardiac looping of mouse embryonic development. Here, we report the cloning of the human Hand1 cDNA and gene from a heart-specific cDNA library and a genomic lambda-DNA library, respectively. We...
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The aim of this case control study was to evaluate the thus far controversially discussed influence of acupuncture (AP) on the duration of labor. Fifty-seven women with AP treatment (group A) were included in our study after spontaneous vaginal full-term delivery. The control group included 63 women (group B). Median duration of the first stage of...
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Our goal was to evaluate the effect of Escherichia coli, Bacteroides fragilis, Mycoplasma hominis, and Staphylococcus aureus on cytokine and prostaglandin production by amnion cells in vitro. Amnion cells were obtained from women undergoing elective cesarean section before the onset of labor and cultured in a primary cell culture. Confluent amnion...
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To describe a new conservative approach in the treatment of heterotopic pregnancy. Case report. A university hospital and an outpatient IVF center. Transvaginal ultrasonography-guided puncture of the ectopic gestational sac and instillation of hyperosmolar glucose. The ectopic pregnancy resolved without further intervention. The intrauterine pregna...
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Our aim was to determine from what time onward fetal fibronectin is consistently detectable in the cervicovaginal secretions before delivery and to what extent the actual time of delivery can be better determined by this procedure than by the sole use of the Bishop score. A fast-reacting fetal fibronectin test was performed on 206 women on their ex...
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Idiopathic hypereosinophilic syndrome (HES) is a rare entity of unknown etiology with a prognosis strongly related to heart involvement that may lead to restrictive endomyocardiopathy. Almost no information about interactions of hypereosinophilia and pregnancy are available. In the English literature there has been only one report of this disease a...
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The purpose of this study was to investigate the placental passage of erythropoietin in a placental perfusion model ex vivo. In an open system 18 placentas were perfused on both the maternal and the fetal side. Erythropoietin and a reference substance were added to either the maternal or fetal perfusion medium. In the first series of experiments, r...
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To determine more precisely the effect of prophylactic low dose aspirin on intrauterine growth retardation and perinatal mortality. Meta-analysis of 13 published randomised clinical trials. We searched 18 medical databases, including MEDLINE since 1964 and EMBASE since 1974, review articles and the references from each retrieved report to identify...
Article
Birth under water has no medical advantages. It seems evident, however, that some women feel better under water have less pain and therefore have an easier delivery. Water births can be allowed under the conditions of clinical studies (establishment of a water birth register and mandatory notification of complications) as long as they are the wish...
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Our purpose was to determine whether nonclosure of the visceral peritoneum at low transverse cesarean delivery has advantages over suture peritonization with regard to postoperative morbidity. A prospective randomized trial of 549 women undergoing cesarean section was carried out; 262 were randomized to nonclosure and 287 to closure of the visceral...
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We performed a metaanalysis of seven published randomized clinical trials to estimate more precisely the effect of prophylactic antibiotics on neonatal mortality, clinical sepsis of the neonate, respiratory distress syndrome, intraventricular hemorrhage, and necrotizing enterocolitis. To evaluate the effect of antibiotic treatment unaffected by oth...
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We examined whether the presence of fetal fibronectin in cervicovaginal secretions can be used as a selection criterion for induction of labor at term. Cervicovaginal secretions of 64 women who were scheduled for induction of labor were examined for fetal fibronectin and divided into group A (positive for fibronectin) and group B (negative for fibr...
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The purpose of this study was to test the hypothesis that nonclosure of the visceral peritoneum in abdominal hysterectomy has distinct advantages over suture reperitonealization with regard to postoperative morbidity. A prospective clinical investigation in 211 women undergoing abdominal hysterectomy was carried out. One hundred five patients were...
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We examined whether the presence of fetal fibronectin in cervicovaginal secretions may be a marker to predict the onset of term labor and delivery. A prospective study was performed in 100 primiparous and multiparous women having reached their expected date of confinement. Fetal fibronectin was assayed by taking samples of both the cervical and vag...
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.6 mg trichosanthin, a drug which is frequently used for midtrimester abortion in China, was applied laparoscopically in a case of tubal pregnancy. No side effects occurred and beta-human chorionic gonadotropin decreased within several days.
Article
There is limited information about uterine hyperstimulation after low-dose prostaglandin E2 therapy. The purpose of this retrospective study was to describe our combined experience with this undesired effect by use of three techniques for prostaglandin E2 administration. Uterine hyperstimulation was present if the contraction frequency was more tha...
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A variety of conservative surgical techniques is available for the termination of ectopic pregnancy with preservation of the tube. We report on a new treatment by means of intratubal prostaglandin F2 alpha application followed by intramuscular administration of a prostaglandin E2 derivative (sulprostone) for 3 days. Only 5 of the 30 patients enroll...

Citations

... 5,4-fach im Ver- gleich zu normotonen Mehrlingen) [6,26], was die Bedeutung eines Screenings zur Prädiktion sowie einer intensivierten Betreuung unterstreicht. Ein adaptiertes intensiviertes Betreuungsregime kann das Auftreten einer HES/PE signifikant reduzieren [7,27]. Darüber hinaus gelten dieselben Betreuungs/ Therapierichtlinien wie bei HES bei Einlingsschwangerschaften [28]. ...
... For pregnant women, a labelling system described by the US Food and Drug Administration (FDA) Pregnancy and Lactation Labeling Rule (PLLR) containing a 5-tier set of alphabetic categories (ABCDX) is widely used to designate the safety of a drug for use during pregnancy [86]. Clindamycin is a broad-spectrum antibiotic that can cover grampositive bacterial and anaerobic bacterial infections and can reduce the incidence of infection-related premature delivery [87][88][89]. As a category B drug, clindamycin is a common antibiotic used for AV infection in pregnant women [90]. ...
... It was hypothesized that activation of platelets during trophoblast invasion in early pregnancy can differ between in preeclamptic and healthy individuals [2]. Altered platelet reactivity was detected in preeclampsia and suggested as an early marker for the disease [12]. Similar to our study, Tzur et al., reported high first-trimester platelet counts in preeclamptic patients [13]. ...
... NICE guidelines on induction of labour [12] defined uterine hyperstimulation as contractions more than 5 in 10 min for more than 20 min or contractions lasting more than 2 min in duration. A retrospective study involving prostaglandin induction of labour [13] showed that hyperstimulation occurred in 5.8% of cases. Arbitrarily, we considered a relative 80% decrease in hyperstimulation risk (estimated hyperstimulation with DBC 1%) as clinically significant. ...
... The first case report describing the use of medical therapy for tubal pregnancy appeared in 1982 (Tanaka et al., 1982). Observational studies in the mid-1980s used, with varying success, methotrexate (Leach and Ory, 1989), prostaglandins (Husslein et al., 1988; Lindblom et al., 1990), actinomycin (Altaras et al., 1988), hyperosmolar glucose (Lang et al., 1990), and anti-HCG antibodies (Frydman et al., 1989). Potassium chloride (Robertson et al., 1987; Aboulghar et al., 1990) is particularly useful in the treatment of heterotopic pregnancy, as it has no effect on the intrauterine fetus(s). ...
... While fFN testing shows an excellent prediction of preterm delivery, its connection to term birth is less clear. After an initial impetus to using fFN to predict term labour and the success of induction of labour at term in the 1990s [15][16][17][18][19], the interest decreased until recently, when newer studies showed a medical and economic benefit [20][21][22]. Transvaginal ultrasound measurement of the cervical length (TVCL) has been reported to be a simple and reproducible examination/marker to predict the time of delivery; however, the results of previous comparative studies are contradictory [23][24][25]. ...
... A negative fetal fibronectin test result from anywhere between 22 and 35 weeks is highly predictive of labour not occurring and has been used to determine this in Nunavut since 2004. [16][17][18] Few publications have examined the applicability of fetal fibronectin testing at term, [19][20][21][22][23][24] with most emphasizing the positive predictive value of the test to plan the timing of induction and to avoid postdates. Three studies noted the average number of days to delivery at term from the last negative fetal fibronectin test result: the study by Ahner et al found a mean interval of 3.8 days (interquartile range 2.4 to 7.0 days), 21 while the study by Luton et al found a mean interval of 5.7 days (range 2 to 16 days). ...
... In fact, there are approximately 200 case reports for tubal molar pregnancies reported in the literature with an incidence estimated to be 1.5 per 1,000,000 pregnancies [4]. The majority of these reports have shown a good prognosis following laparoscopic salpingectomy [5][6][7][8][9]. The follow-up differs after a normal ectopic pregnancy compared to a molar ectopic pregnancy [5][6][7][8][9]. ...
... 3,4 Several studies are conducted comparing short term and long-term outcomes of closure and non-closure of peritoneum, but there is no consensus whether either procedure is beneficial to patients. [5][6][7][8] Variability of results may be due to bias involved in these studies, as two groups compared had different characteristics like obstetrics versus non-obstetrics laparotomies, indication for LSCS being elective or emergency, vertical versus Pfannenstiel incisions which are likely to affect short term outcome besides those due to peritoneal closer versus non closure. This motivated us to conduct unbiased study of short-term outcome in elective LSCS in unscarred abdomens with Pfannenstiel incisions. ...
... The prevalence of prelabour rupture of fetal membranes in this study was 1.98% which is lower than figures reported from studies done in Enugu 18 , and Nnewi 19 , but higher than the rate from Kano 8 . Also, this prevalence rate is lower than the 3-8% reported from previous systematic review 20 . This low prevalence of PROM might be due to the retrospective nature of the study such that patients with short latency period who presented in spontaneous labor were not captured while some patients who had had PROM but presented later in the hospital in established labor might also not be documented as PROM. ...