Peter E. Tanguay’s research while affiliated with University of California, Los Angeles and other places

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Publications (48)


Hemisphere and ear asymmetry in the auditory evoked response to musical chord stimuli
  • Article

March 2013

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15 Reads

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13 Citations

Physiological Psychology

John M. Taub

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Peter E. Tanguay

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Catherine N. Doubleday

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[...]

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The human averaged auditory evoked response (AER) to monaurally presented musical chord stimuli was recorded simultaneously from electrodes placed symmetrically over the two cerebral hemispheres at central and Wernicke (W) scalp locations. Stimulus presentation was quasi-random to the left (L) and right (R) ears of 14 normal-hearing right-handed male university students. The mean integrated amplitude over the initial 300 msec of the AER reflected asymmetries at the W locations as a function of hemisphere derivation and ear stimulated. The major interhemispheric difference observed when effects of contralateral auditory pathway-to-cortex projections had been equated was a significantly greater magnitude integrated amplitude response at the right (W2) scalp site to L-ear stimulation in comparison with the AER at the left (W1) cortical location to Rear stimulation. Differences of AERs between hemispheres summed across both ears stimulated conceived as attributable to additive auditory input showed a significantly greater integrated amplitude value at W2. When effects of contralateral auditory pathway predominance were examined, the AER integrated amplitude from W2 exceeded the hemisphere response at W1 to L-ear stimulation. The demonstrated asymmetries in the evoked response to musical chords may be associated with preponderance of the right hemisphere and saliency of the L ear for nonverbal, nonmeaningful auditory stimuli.


Autistic children and the object permanence task
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  • Full-text available

February 1993

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2,750 Reads

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10 Citations

Acta Paedopsychiatrica

Many mentally retarded autistic children can understand the concept of object permanence, but, in comparison to developmental-age matched normal children, the behavioral strategies they employ in carrying out the Casati-Lezine Object Permanence Test are deficient and lead to failure. These deficiencies appear unrelated to interference of stereotypic or other bizarre behavior in task performance. Similar problem-solving deficiencies can be found in mentally retarded children who are not autistic, suggesting that the deficiencies themselves are less related to the social-communication deficits of autistic children, but more to the general problem-solving difficulties found in children with a lower developmental quotient. Nevertheless, the qualitative analysis of results shows a tendency in autistic children, despite their better developmental level, to use less coordinated and regular sequences to solve the task than normal or mentally retarded children.

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Regional cerebral glucose metabolism and attention in adults with a history of childhood autism

October 1992

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9 Reads

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91 Citations

The Journal of Neuropsychiatry and Clinical Neurosciences

Sixteen high-functioning adults with a history of childhood autism and 26 normal control subjects underwent [18F]fluoro-2-deoxyglucose positron-emission tomography to assess regional cerebral glucose metabolic rate (GMR). Autistic patients had a left > right anterior rectal gyrus asymmetry, as opposed to the normal right > left asymmetry in that region. Patients also showed low GMR in the left posterior putamen and high GMR in the right posterior calcarine cortex. Brain regions with GMR > 3 SD from the normal mean were more prevalent in patients than in control subjects. This variable pattern of abnormal activity is consistent with heterogeneous neurophysiological etiology; group differences in striatum and cortex may represent a final common pathway.



Midlatency auditory evoked responses: P1 abnormalities in adult autistic subjects

March 1992

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27 Reads

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89 Citations

Electroencephalography and Clinical Neurophysiology

MLR recordings from a group of 11 high-functioning adult autistic subjects were compared with those from a control group of 11 normal subjects. Components selected for analysis were "Pa", the maximum positivity in the 25-40 msec latency range following stimulus onset, "P1", the maximum positivity within the 50-65 msec latency range, and "Nb," the maximum negative deflection in the 40-50 msec latency range. Statistical analyses of amplitude and latency data were conducted using repeated measures analysis of variance and t test group comparisons. The Pa component showed no significant difference between autistic and control groups. However, 2 types of abnormality were noted in the P1 component: (1) the P1 component was significantly smaller in the autistic subjects at slow rates of stimulation, and (2) the autistic P1 did not change as rates of click stimulation increased from 0.5 to 10/sec, in contrast to the normally produced P1 decrement. Data from the P1 model in the cat, and complementary data from the human, closely link the generator substrate of the P1 potential to cholinergic components of the ascending reticular activating system (RAS) and their thalamic target cells. This is the first report of abnormal P1 responses in autism and strongly suggests that the RAS and/or its post-synaptic thalamic targets may be dysfunctional in this syndrome.


P3 responses to prosodic stimuli in adult autistic subjects

November 1991

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56 Reads

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42 Citations

Electroencephalography and Clinical Neurophysiology

Autistic persons are known to have serious abnormalities in speech prosody. The present study attempted to ascertain whether autistic persons could discriminate and/or recognize prosodic contrasts in auditory stimuli. A group of 11 adult autistic subjects with normal IQ and an age-matched group of normal subjects were studied electrophysiologically and behaviorally during presentations of prosodic and phonemic stimuli. The cognitive P3 potential was recorded in response to rare (20%)/frequent (80%) presentations of phonemic stimuli, 'ba/pa,' linguistic-prosodic stimuli, 'Bob.' (statement)/'Bob?' (question), and emotional-prosodic stimuli, 'Bob' (happy)/'Bob' (angry). Behaviorally, auditory discrimination was tested by requiring a button-press response to each presentation of the rare target stimulus and cognitive association was tested by requiring a match between the verbalized stimulus and an appropriate picture/word. Contrary to our hypothesis, the autistic subjects generally showed normal P3 responses to all stimuli and performed at a normal level in all behavioral tests. However, a significant autistic P3 response to the phoneme 'pa' was not demonstrated. This surprising result was reexamined and shown to reflect an unusually large autistic response to 'pa' as the frequent stimulus in the first recording block, this initial hyper-reactivity prevented a 'frequent/rare' differential when 'pa' was presented as the rare stimulus in a later recording block. In the P3 latency window, both the autistic and control groups showed the largest amplitude responses to emotional-prosodic stimuli; neither the N1 nor P2 showed these stimulus effects. Thus, 'emotional sounds' appear to be particularly effective in activating the neural substrate of the P3 generator system. Overall, these data indicate remarkably normal P3 and behavioral processing of prosodic stimuli by the high-functioning autistic subjects of this study.


Formal Thought Disorder in Childhood Onset Schizophrenia and Schizotypal Personality Disorder

December 1990

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26 Reads

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59 Citations

The Kiddie Formal Thought Disorder Rating Scale (K-FTDS) was examined in a sample of 29 schizophrenic, 10 schizotypal, and 54 normal children, aged 5-12.5 yrs. The schizophrenic and schizotypal children had significantly more illogical thinking and loose associations than the normal children. There were no significant differences between the illogical thinking and loose associations ratings of the schizophrenic and schizotypal children. Young schizophrenic, schizotypal, and normal children had more illogical thinking and loose associations than older children in their respective groups. The diagnostic, developmental, and cognitive implications of the study's results are discussed.


The Behavioral Summarized Evaluation: Validity and reliability of a scale for the assessment of autistic behaviors

July 1990

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55 Reads

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101 Citations

Journal of Autism and Developmental Disorders

The Behavioral Summarized Evaluation (BSE), is a 20-item paper-and-pencil rating scale specifically designed for the measurement of behavioral parameters which could be related to biological data in autistic children involved in educational programs, neurophysiological studies, and therapeutic trials. The development of the scale, the validity, and reliability studies are presented in this paper. The results suggest that the BSE is an acceptable tool for the assessment of autistic behaviors, easy to handle, and accessible to both professionals and paraprofessionals of the medico-educative staff. It is a useful addition to the bioclinical researcher's evaluation battery for bioclinical and therapeutic studies. However, more work is suggested to further investigate the psychometric properties of this behavior assessment instrument.


Childhood-Onset Schizophrenia

January 1990

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10 Reads

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2 Citations

Although prepubertal children have been known since the turn of the present century to exhibit symptoms of “schizophrenia” (DeSanctis 1906), it has only been in the past 20 years that careful studies of childhood-onset schizophrenia have been reported. In the present chapter we will describe the acute symptoms of the disorder, review the few studies available which describe the prodromal features of the illness, and discuss what information we may learn from study of the children of schizophrenic mothers in regard to the phenotypic manifestations of schizophrenia in children. We will also review studies which attempt to identify core psychological impairments in schizophrenic children, and which examine certain information processing functions in these children. These studies indicate that schizophrenic children have deficits which parallel those seen in adult-onset schizophrenia. We will conclude with a discussion of treatment, as well as some practical suggestions for future research.


The Kiddie Formal Thought Disorder Rating Scale (K-FTDS): Clinical assessment, reliability, and validity

June 1989

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385 Reads

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113 Citations

Journal of the American Academy of Child & Adolescent Psychiatry

The Kiddie Formal Thought Disorder Story Game and the Kiddie Formal Thought Disorder Scale were administered to schizophrenic, schizotypal, and normal children, aged 5 to 13 years. The story game elicited more elaborate speech samples than did a structural clinical interview focused on psychotic symptomatology. The sum of illogical thinking and loose associations was a reliable kappa = 0.77), sensitive (79%), and specific (90%) indicator of schizophrenia in this sample. It also demonstrated significant developmental changes in the schizophrenic and normal subjects. Incoherence and poverty of content of speech were infrequently rated in both schizophrenic and normal subjects.


Citations (40)


... In contrast to the consistent findings of waves III and V in individuals with ASD, the evidence of abnormalities in wave I latency remains equivocal (Pillion et al., 2018). Some studies reported normal absolute wave I latencies (Courchesne et al., 1985;Demopoulos and Lewine, 2016;Garreau et al., 1984;Grillon et al., 1989;Known et al., 2006;Magliaro et al., 2010;Miron et al., 2016;Rosenblum et al., 1980;Santos et al., 2017;Sersen et al., 1990;Skoff et al., 1980;Tharpe et al., 2006), and others reported abnormal latencies that were prolonged (Azouz et al., 2014;Rosenhall et al., 2003;Roth et al., 2012;Tanguay et al., 1982) or shortened (Dabbous, 2012). The reason for these diverse results may be that ASD participants with a wide age range were tested (e.g., range 3-24 years; 4-21 years). ...

Reference:

Auditory brainstem responses in adults with autism spectrum disorder
Auditory brainstem evoked responses in autistic children
  • Citing Article
  • May 1982

Archives of General Psychiatry

... In early AEF research, it was found that when simple sounds were presented monaurally, responses in the hemisphere contralateral to the sound presentation were more pronounced than responses in the ipsilateral hemisphere (Tunturi 1946;Rosenzweig 1951). This increased magnitude in contralateral auditory responses has since been confirmed in a number of experimental paradigms and recording modalities (Peronnet et al. 1974;Andreassi et al. 1975;Taub et al. 1976;Wolpaw and Penry 1977;Reite et al. 1981;Pantev et al. 1986Pantev et al. , 1998Yoshiura et al. 1994;Loveless et al. 1994;Mäkelä et al. 1994;Jäncke et al. 2002;Devlin et al. 2003;Petkov et al. 2004;Parviainen et al. 2019). In addition, the contralateral response has been described as not only larger in magnitude, but also as faster than its ipsilateral equivalent (Mononen and Seitz 1977;Wolpaw and Penry 1977;Mäkelä et al. 1994;Pantev et al. 1998). ...

Hemisphere and ear asymmetry in the auditory evoked response to musical chord stimuli
  • Citing Article
  • March 2013

Physiological Psychology

... All children were of normal physical development and were in good physical health. They were all audiologically normal as assessed using brainstem auditory evoked potential (BAEP) criteria as previously detailed in Garreau et al. (1984). None had a history of endocrine or systemic disease. ...

Etude des potentiels evoques auditifs du tronc cerebral chez l'enfant normal et chez l'enfant autistique
  • Citing Article
  • June 1984

Revue d Electroenc&#xE9 phalographie et de Neurophysiologie Clinique

... children (Lelord et al., 1978;Garreau et al., 1980;Martineau et al ., 1981;Martineau et al., 1984). In one study (Garreau et al., 1980) urinary HVA excretion was correlated with the severity of autistic symptoms. ...

Relations entre les potentiels evoques auditifs (presence, amplitude) au cours du conditionnement son-lumiere et les taux de derives de la dopamine dans l'autisme de l'enfant
  • Citing Article
  • November 1984

Revue d Electroenc&#xE9 phalographie et de Neurophysiologie Clinique

... The ABR has provided the most insight into the function of brainstem centers in ASD. The majority of studies of the ABR in subjects with ASD over the past 40 years provide evidence that subjects with ASD have smaller amplitudes in waves I, II, III, IV, and V (Ornitz et al., 1972;Gillberg et al., 1983;Martineau et al., 1987Martineau et al., , 1992Klin, 1993), longer latencies between waves I-III and waves I-V (Taylor et al., 1982), and longer latencies/slower responses (Ornitz, 1969;Student and Sohmer, 1978;Rosenblum et al., 1980;Sohmer, 1982;Tanguay et al., 1982;Gillberg et al., 1983;Sersen et al., 1990;Thivierge et al., 1990;Wong and Wong, 1991;Maziade et al., 2000;Kwon et al., 2007;Roth et al., 2012;Azouz et al., 2014;Taş et al., 2017;Miron et al., 2018Miron et al., , 2021Ramezani et al., 2019;Delgado et al., 2021;reviewed in Talge et al., 2018). These longer latency and lower amplitude responses have been attributed to the immaturity of brainstem circuits (Li et al., 2020). ...

The effect of stimulus interval on the auditory evoked response during sleep in autistic children
  • Citing Article
  • June 1972

Journal of Autism and Developmental Disorders

... Another finding in this study is that spindle EEG activity is found in autistic children but not found in the control group. It showed that sleep stages in children with ASD are not well differentiated [36]. Wakefulness and sleep in humankind, are regulated by the suprachiasmatic nucleus known as the circadian clock. ...

Rapid eye movement (REM) activity in normal and autistic children during REM sleep
  • Citing Article
  • September 1976

Journal of Autism and Developmental Disorders

... Previous studies reported increases in low-frequency BOLD activity (<0.1 Hz) from wake to light sleep (7)(8)(9), as well as increases in higher-frequency BOLD activity (>0.1 Hz) from wake to propofol anesthesia (10). Although the relationships between these BOLD spectral changes and spindle or slow wave activity were not examined, it is interesting to note that propofol anesthesia can induce slow waves similar to those of NREM sleep (11), which might underlie the observed increase in highfrequency BOLD activity; moreover, the emergence of sleep spindles during child development (12) coincides with an increase in low-frequency BOLD activity (13). These studies hinted at a possible link between BOLD frequency content and spindle or slow wave activity. ...

Evolution of sleep spindles in childhood
  • Citing Article
  • March 1975

Electroencephalography and Clinical Neurophysiology

... Researchers have reported a significantly greater attenuation of the MMN response for stimuli delivered at longer ISIs in specific clinical populations including the elderly (Gaeta et al, 1998;Woods 1992;Pekkonen et al, 1996), children with CATCH 22 syndrome learning problems (Kraus et al, 1996;Cheour et al, 1997), and those suffering from Parkinson's disease (Pekkonen et al, 1994), Alzheimer's disease (Kazmerski et al, 1997), chronic alcoholism (Ahveninen et al, 2000;Grau et al, 2001), and coma (Kane et al, 1993). Since certain neural refractory functions are also known to vary with different forms of CNS dysfunction (Shagrass et al, 1971;Alho et al, 1994;Ornitz et al, 1974;Papanicolaou et al, 1984;Shucard et al, 1984), it is possible that in some studies, the MMN response and neural refractory effects may temporally overlap. If that were the case, erroneous interpretations of the clinical significance of the altered waveform morphology could result. ...

The recovery cycle of the averaged auditory evoked response during sleep in normal children
  • Citing Article
  • September 1974

Electroencephalography and Clinical Neurophysiology

... Wenn ein Hörschaden retrocochleärer Art vorliegt, kann der Patient zumeist nicht von einem CI protieren. Die in der Cochlea entstehenden Stimulationen können dann nicht oder nur stark asynchron weitergeleitet werden (Jackson et al., 2002;Colletti et al., 2005 (Hitselberger et al., 1984), wovon die Patientin noch Jahrzehnte später protierte (House und Hitselberger, 2001 (Vincent, 2012(Vincent, , S. 1985 (Vincent, 2012(Vincent, , S. 1984 können Antwortwellen sicher nachgewiesen werden (Lehnhardt und Laszig, 2009, S. 206 (Elberling und Don, 2008;Rodrigues et al., 2013;Interacoustics, 2007, 3-27 + 3-78f (Tanguay et al., 1973). Um dies zu verhindern kann beispielsweise während der Messung gelesen oder ein stummes Video angesehen werden (Dun et al., 2015, S. 9). ...

Basic rest-activity cycle rhythms in the human auditory evoked response
  • Citing Article
  • July 1973

Electroencephalography and Clinical Neurophysiology

... This question will arise when designing a REM-probe study across the lifespan. REM sleep latency increases linearly as newborns age, reaches its maximum (around 200 minutes) at age 6-7 years 72,73 , and then gradually decreases to around 100 minutes by age 18 years 73,74 and 60 minutes by age 80 years 74 . The long REM sleep latency of children will probably require two consecutive overnight assessments for REM-probe studies, as in our REM-probe studies in adults 9 . ...

Rapid eye movement (REM) activity in normal and autistic children during REM sleep
  • Citing Article
  • October 1976

Journal of Autism and Childhood Schizophrenia