Pengcheng Lv’s research while affiliated with Chinese Academy of Sciences and other places

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Publications (2)


Context-dependent Grid-like Representations of Theta Power in Human Entorhinal Cortex
  • Article

August 2024

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46 Reads

Neuroscience Bulletin

Pengcheng Lv

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Hui Zhang

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[...]

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Fig. 1. Task, behavioral results, and hypothesis. (A) Left: Object-location memory task. Right: Calculation of drop error in each trial as the Euclidean distance between the response location (green dot) and the correct object location (red dot). (B) Patients received feedback via one of five smileys that were color-coded according to the drop error. For example, light green smileys were shown for drop errors within a radius of 700 to 1500 vu. We divided the trials into three conditions: good (dark and light green), middle (yellow), and bad (dark and light red). (C) Histogram of drop errors across all trials and all patients. Red line, average chance performance across patients. (D) Change in mean drop error between the first three and last three sessions. Gray lines, data from individual patients. **P < 0.01. (E) Sampling per 30° bin of movement direction in 360° space. Error bars indicate SEM across participants. Gray dots indicate value from individual participants. (F) Left: Schematic depiction of firing fields for one grid cell. Right: Schematic depiction of a sixfold rotationally symmetric modulation of oscillatory power by movement direction.
Fig. 2. Medial prefrontal theta power exhibits sixfold modulation by movement direction. (A) Top: Grid-like representations cluster obtained in the high theta band displayed in MNI standard space. The color bar denotes cluster-corrected t values (permutation test, P < 0.01). Bottom: Depiction of all electrode contacts in vmPFC and EC (black circles) relative to two control regions (dmPFC and OFC). A, anterior; P, posterior; V, ventral; D, dorsal. (B) Raw  scores for sixfold modulation of vmPFC oscillatory power in the high theta band. Black dots, individual subjects. *P < 0.05 after Bonferroni correction for four bands. (C) Mean Z  scores across subjects with electrodes in vmPFC, separately computed for four different frequency bands: low theta (2 to 5 Hz), high theta (6 to 9 Hz), beta (12 to 30 Hz), and low gamma (30 to 60 Hz). *P < 0.05 after Bonferroni correction for four bands. (D) Theta power was higher during movements aligned with the grid axes as compared to misaligned movements. Purple, aligned; gray, misaligned. (E) Mean subject Z  scores for different symmetry patterns. *P < 0.05 after Bonferroni correction for fivefold. (F) Mean subject Z  in control regions. Error bars in (B) to (F) indicate SEM across participants. Gray dots in (B) to (F) indicate value from individual participants. (G) Distribution of mean grid orientations across subjects does not reveal a significant clustering (Rayleigh test: P = 0.88). n.s., nonsignificant.
Fig. 3. Coordinated grid-like representations between vmPFC and EC. (A) Z-scored  vmPFC->EC scores across subjects show that theta oscillations in the EC are aligned to preferred grid orientations in the vmPFC. This effect was not observed for four-, five-, seven-, or eightfold symmetry. **P < 0.01. (B) Separate depiction for all aligned (blue) and misaligned (gray) trajectories. Error bars in (A) and (B) indicate SEM across participants. Gray dots in (A) and (B) indicate value from individual participants. (C) Pair-wise z-scored  values for all electrodes in vmPFC and EC in both directions are highly correlated. Inset: Interindividual correlation over subject-wise averages of grid cell-like representations in the two analysis directions. (D) vmPFC and EC show similar grid orientations both across pairs and subjects.
Fig. 4. Theta-based interactions between vmPFC and EC carry information about grid-like representations and predict spatial navigation performance. (A) Top: Example raw trace during the retrieval phase illustrating strong theta band coherence between vmPFC and EC. Bottom: Z-scored imaginary coherence between vmPFC and EC signals. Green bar at the top denotes significant cluster after correction for multiple comparisons (**P < 0.01). Right: Z-scored imaginary coherence of vmPFC and EC at 4 to 9 Hz. Error bars indicate SEM across participants. Gray dots indicate value from individual participants. (B) Electrode-pair level (n = 114) z-scored  vmPFC->EC scores are correlated with z-scored 4 to 9 Hz imaginary coherence (LME, **P < 0.01). (C) Left: Trial-wise z-scored 4 to 9 Hz of imaginary coherence for one example vmPFC-EC pair correlated with drop error. Right: Slope of the best-fitting line of all pairs (LME, **P < 0.01). The negative slope indicates that imaginary coherence is higher in trials with better performance. (D) Mean z-scored 4 to 9 Hz imaginary coherence is significantly different between good and bad trials (LME, ***P < 0.001). Error bars in (C) and (D) indicate SEM across electrode pairs. Gray dots in (C) and (D) indicate value from each pair. (E) Angular histograms of mean vmPFC-EC phase lag (n = 114 pairs) in the theta band (Rayleigh test, ***P < 0.001). (F) Granger causality analyses show significant influence from vmPFC to EC (top) but not in the reverse direction (bottom). The gray lines denote 95% confidence intervals of the null distribution. a.u., arbitrary units.
Theta oscillations coordinate grid-like representations between ventromedial prefrontal and entorhinal cortex
  • Article
  • Full-text available

October 2021

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204 Reads

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19 Citations

Science Advances

Grid cells and theta oscillations are fundamental constituents of the brain's navigation system and have been described in the entorhinal cortex (EC). Recent fMRI studies reveal that the ventromedial prefrontal cortex (vmPFC) contains grid-like representations. However, the neural mechanisms underlying human vmPFC grid-like representations and their interactions with EC grid activity have remained unknown. We conducted intracranial elec-troencephalography (iEEG) recordings from epilepsy patients during a virtual spatial navigation task. Oscillatory theta power in the vmPFC exhibited a sixfold rotational symmetry that was coordinated with grid-like representations in the EC. We found that synchronous theta oscillations occurred between these regions that predicted navigational performance. Analysis of information transfer revealed a unidirectional signal from vmPFC to EC during memory retrieval. Together, this study provides insights into the previously unknown neural signature and functional role of grid-like representations outside the EC and their synchronization with the entorhinal grid during human spatial navigation.

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Citations (1)


... This model is backed up by a previous MEG study revealing that the vmPFC directs hippocampal activity during the initiation of AM retrieval (McCormick et al., 2020). This finding has been replicated and extended by Chen et al., 2021, showing that the vmPFC leads hippocampal involvement during scene construction and other scene-based processes (Monk et al., 2021). Moreover, the connection between the hippocampus and the visual-perceptual cortex seems equally crucial. ...

Reference:

Hippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia
Theta oscillations coordinate grid-like representations between ventromedial prefrontal and entorhinal cortex

Science Advances