August 2024
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46 Reads
Neuroscience Bulletin
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August 2024
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46 Reads
Neuroscience Bulletin
October 2021
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204 Reads
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19 Citations
Science Advances
Grid cells and theta oscillations are fundamental constituents of the brain's navigation system and have been described in the entorhinal cortex (EC). Recent fMRI studies reveal that the ventromedial prefrontal cortex (vmPFC) contains grid-like representations. However, the neural mechanisms underlying human vmPFC grid-like representations and their interactions with EC grid activity have remained unknown. We conducted intracranial elec-troencephalography (iEEG) recordings from epilepsy patients during a virtual spatial navigation task. Oscillatory theta power in the vmPFC exhibited a sixfold rotational symmetry that was coordinated with grid-like representations in the EC. We found that synchronous theta oscillations occurred between these regions that predicted navigational performance. Analysis of information transfer revealed a unidirectional signal from vmPFC to EC during memory retrieval. Together, this study provides insights into the previously unknown neural signature and functional role of grid-like representations outside the EC and their synchronization with the entorhinal grid during human spatial navigation.
... This model is backed up by a previous MEG study revealing that the vmPFC directs hippocampal activity during the initiation of AM retrieval (McCormick et al., 2020). This finding has been replicated and extended by Chen et al., 2021, showing that the vmPFC leads hippocampal involvement during scene construction and other scene-based processes (Monk et al., 2021). Moreover, the connection between the hippocampus and the visual-perceptual cortex seems equally crucial. ...
October 2021
Science Advances