Peng Hu's research while affiliated with Chinese PLA General Hospital (301 Hospital) and other places

Publications (7)

Article
Full-text available
Receptor-interacting protein 3- (RIPK3-) modulated necroptosis plays a critical role in cardiac remodelling after myocardial infarction (MI). However, the precise regulatory mechanism is not fully elucidated yet. In the present study, we showed that RIPK3 expression was upregulated in myocardial tissue after MI in a mouse model by coronary artery l...
Article
The coronavirus disease 2019 (COVID-19) triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) erupted in Hubei Province of China in December 2019 and has become a pandemic. Severe COVID-19 patients who suffer from acute respiratory distress syndrome (ARDS) and multi-organ dysfunction have high mortality. Several studies have sho...
Article
Full-text available
The COVID-19 pandemic is a significant global event in the history of infectious diseases. The SARS-CoV-2 appears to have originated from bats but is now easily transmissible among humans, primarily through droplet or direct contact. Clinical features of COVID-19 include high fever, cough, and fatigue which may progress to ARDS. Respiratory failure...
Article
Full-text available
Background: The global death toll from COVID-19 virus exceeds 21000. The risk factors for death were attributed to advanced age and co-morbidities, but haven't been accurately defined. Objectives: To report the clinical features of 85 fatal cases with COVID-19 in two hospitals in Wuhan. Method: Medical records of 85 fatal cases of COVID-19 bet...
Article
With over 1,800,000 cases and 110,000 deaths globally, COVID-19 is one of worst infectious disease outbreaks in history. The objective of this paper is to critically review the available evidence regarding the lessons learned from the Chinese experience regarding COVID-19 prevention and management. The steps that have led to a near disappearance of...

Citations

... Zhu et al. found that receptor-interacting protein 3-(RIPK3-) mediated necroptosis plays a key role in cardiac remodeling [109]. The expression level of RIPK3 was further upregulated in myocardial tissue after myocardial infarction in a mouse model of coronary artery ligation and in myocardial cells after hypoxic injury in vitro. ...
... On the other hand, one of the hallmarks of severe COVID-19 infection is cytokine release syndrome (CRS) [49]. It was determined in several studies that the levels of proinflammatory cytokines were higher in patients with COVID-19 compared to the healthy control subjects, while among the COVID-19 infected, they were significantly higher in the ICU-treated patients than in non-ICU-treated patients [50,51]. ...
... From the first reviews on COVID-19, analyses have shown pneumonia as the most frequent medical manifestation. COVID-19-related pneumonia may be subsequently accompanied with ARDS, which is currently considered a hallmark of the immune-mediated clinical effect in SARS-CoV-2, and is consistent with the extremely acute respiratory syndrome (SARS-CoV) and MERS-CoV infections as two different varieties of acute respiratory infections resulting from Coronaviruses [32]. Moreover, ARDS can be described as a generalized and uncontrolled inflammatory response, which is potentially responsible for a wide range of morbidities and mortalities amongst the infected cases. ...
... In the past centuries, the incidence of diseases has dramatically increased due to simple medical intervention. Nowadays, the intervention and prevention strategies of diseases dissemination are developing in parallel with the development of the medical sector [25]. However, several diseases such as cancer and diabetes are still continuously prevalent affecting the global quality of life [7]. ...
... Изучению развития нарушений сердечного ритма у пациентов, госпитализированных с COVID-19, посвящено много работ. Так, частота развития аритмий у госпитализированных пациентов варьировала от 8 до 17% и достигала 44-60% в отделениях интенсивной терапии [1][2][3][4][5]. В одном из крупных международных исследований с участием более 4500 пациентов частота появления аритмии составила 18%, при этом наиболее частыми их формами при COVID-19 были фибрилляция/трепетание предсердий [6]. ...
... A good COVID-19 prognosis is also linked to a high blood eosinophil count, common finding in allergic diseases in the context of a Th2 response [20]. Du Y et al., reported that eosinopenia was found in about 80% of patients died for COVID-19, considering it as a biomarker of worse prognosis and a predictor for the development of COVID-19 severity [22]. ...