Peishan Qiu's research while affiliated with Hubei Biopesticide Engineering Research Centre and other places

Publications (12)

Article
The inactivation of tumor suppressor DOC-2/DAB2 interactive protein (DAB2IP) by epigenetic and post-transcriptional modification has been reported in multiple human malignancies. DNA methyltransferase 3A (DNMT3A) is involved in de novo establishment of DNA methylation and plays a vital role in tumorigenesis. However, whether DNMT3A can regulate col...
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Background: Ulcerative colitis (UC) is a chronic recurrent disease of unknown etiology. Recently, it has been reported that autophagy-related gene polymorphism is closely associated with increased risk of UC, and the therapeutic effect of some UC drugs is mediated by regulating autophagy pathways. This study aims to identify pivotal autophagy-relat...
Article
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Colorectal carcinoma (CRC) remains a huge challenge in clinical treatment due to tumor metastasis and recurrence. Stem cell-like colon tumor-repopulating cells (TRCs) are a subpopulation of cancer cells with highly tumorigenic and chemotherapy resistant properties. The core transcription factor c-Myc is essential for maintaining CSC phenotypes, yet...
Article
Background: Inflammatory bowel disease (IBD) is a chronic idiopathic gastrointestinal disease. Increasing evidence suggests that microRNAs (miRNAs) may participate in the pathophysiology of IBD. Methods: A miRCURY™ LNA Array and in situ hybridization were employed to screen for differentially expressed miRNAs (DEMs) in fecal specimens from 41 IB...
Article
Fatty acid transport protein 2 (FATP2) is a multifunctional protein whose specific function is determined by the type of located cell, its intracellular location, or organelle-specific interactions. In the different diseases setting, a newfound appreciation for the biological function of FATP2 has come into view. Two main functions of FATP2 are to...
Article
The main symptoms of coronavirus disease 2019 (COVID-19) are respiratory manifestations, while some confirmed patients developed gastrointestinal symptoms or even initially presented digestive symptoms. The link between pneumonia and gastrointestinal symptoms caused by severe acute respiratory symptoms coronavirus 2 focused our attention on the con...
Article
Background: Ischemic colitis (IC) was investigated to be associated with dyslipidemia and subcutaneous adipose tissue. Nonalcoholic fatty liver disease (NAFLD) is associated with ischemic diseases such as coronary heart disease, ischemic stroke. But there is a paucity of data regarding the association between NAFLD and IC. NAFLD may be associated...
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Background At present, novel coronavirus disease 2019 (COVID-19) has become a serious global public health problem. The current meta-analysis aimed to find risk factors for the COVID-19-related death, helping to enhance the efficacy and reduce the mortality of COVID-19.Methods We searched PubMed, Embase, medRxiv, and Cochrane Library for articles p...
Article
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Background: Consumption of ultra-processed foods (UPFs) plays a potential role in the development of obesity and other diet-related noncommunicable diseases (NCDs), but no studies have systematically focused on this. This study aimed to summarize the evidence for the association between UPFs consumption and health outcomes. Methods: A comprehens...
Article
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Nonalcoholic steatohepatitis (NASH), the advanced stage of nonalcoholic fatty liver disease (NAFLD), is emerging as a leading cause of progressive liver fibrosis and end-stage liver disease. Liver macrophages, mainly composed of Kupffer cells (KCs) and monocyte-derived macrophages (MoMFs), play a vital role in NASH progression and regression. Recen...
Article
Backgrounds: Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. Our study aimed to evaluate the association of liver injury and gastrointestinal symptoms (GIS) with the progression of COVID-19. Methods: A comprehensive search was performed on the PubMed to identi...
Article
Backgrounds and aims: Microsatellite instability (MSI) is one of the promising biomarkers in human colorectal cancers (CRCs), and it is influenced by an intricate gene interaction network. Hence, we aimed to identify and validate hub genes associated with MSI CRC and to illustrate its underlying mechanisms. Methods: Weighted gene co-expression n...

Citations

... 34 It was found that DNMT3A could attenuate the proliferation of CRC cells by effectively downregulating the DAB2IP-activated MEK/ERK signaling pathway. 35 Li et al. 36 revealed the potential mechanism of DNMT3A effects in CRC as involving methylation of the AGR2 promoter, thereby inhibiting the oncogenic activity of AGR2 in CRC tumorigenesis and progression. ...
... These tumor cells have similar characteristics as CSCs and were also called tumor repopulating cells (TRCs) [21]. Then, we also used the 3D fibrin gel to successfully enrich the colon TRCs which were examined by colony formation, tumorigenicity, and drug resistance, and the stemness markers, such as CD133, CD44, SOX2, and OCT4, were also verified to be upregulated [22,23]. There have been reportsthat CSCs promote the malignant characteristics of HCC and clarified the importance of CSCs in treatment [24]. ...
... Apart from the downstream pathways of WWP1 in ICC, we also detected the upstream causes upregulation of WWP1 in ICC. Previous reports revealed that multiple miRNAs and transcription factors regulate the expression of WWP1, such as miR-584-5p, miR-30a-5p, miR-16-5p, KLF2/5, MYC, SOX9, and so on [16,21,[28][29][30][31]. Among these, MYC was of our interest, because MYC is proved to be a critical oncogene that drives many types of cancer tumorigenesis. ...
... In the last few years, it has been found that SLC27A2 not only affects intracellular lipid homeostasis but also plays an important role in type 2 diabetes, renal fibrogenesis, and tumor progression. [12][13][14] In a recently published study, Veglia et al. have demonstrated that SLC27A2 has immunosuppressive effects on neutrophils and promotes tumor growth. ...
... Most of the described links between pulmonary and intestinal tissue are based on the shared embryological origin in the foregut portion of the endoderm, leading to the possibility of a cross-mucosal interaction between the two organs that compose the human mucosal immune system [21,22]. Although much of this gut-lung interaction is not finally understood, both organs show a similar architecture, being composed of an extensive mucosal surface (with goblet cells and submucosal glands), containing lymphoid tissue (innate and adaptive immunity) and being covered by mucus, commensal bacteria and other antigens [16,[23][24][25]. ...
... This has created a higher preference for convenience foods that are often highly processed and contain excessive sugar, salt and saturated fat. In addition, with increased urban incomes, preferences for and consumption of animal-source and ultra-processed foods increase 76,77 . While these dietary shifts have led to lower micronutrient deficiencies among the affluent urban population, in the longer run, they have also led to a substantial rise in cardiometabolic diseases due to imbalanced and unhealthy diets and lower physical activity [78][79][80][81][82][83] . ...
... Hypertension, diabetes, and respiratory diseases were the most frequent comorbidities in severe and fatal cases. Ref. [8] founded that about 66.6% of the deaths caused by from COVID-19 were to men, with a mean age of 69.9 years. In addition, a high incidence of hypertension, diabetes, low platelet levels, and chronic cerebrovascular and cardiovascular diseases were observed among the deceased. ...
... Prog, Progression phase; Regr, Regression phase; Log2FC, log2-foldchange based on low cholesterol age-matched group. role: they can cross-communicate with neutrophils, natural killer cells, innate lymphoid cells, and lymphocytes, coordinating cell recruitment, activation, and subsequent fate of hepatic inflammation (29)(30)(31)(32). ...
... Diarrhea was the most common GI symptom in our cohort (82.7%) which was similar to findings from Wang et al. [26]. Moreover, Shousha et al. [24], an Egyptian multicentric cohort study, agreed with our results where 86.67% had diarrhea. ...
... The "WGCNA" R package was used to construct a network as previously described. 14,15 All screened DEGs were used to calculate the Pearson's correlation, and then a weighted adjacency matrix was constructed through a power function a mn = |cmn| β , where c mn represents Pearson's correlation between gene m and gene n, and a mn represents adjacency between gene m and gene n. To stress the correlations between genes and penalize weak correlations, a soft threshold β was calculated to construct a scale-free network ( Figure 1). ...