Paul E Herbert's research while affiliated with Imperial College London and other places
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Publications (11)
Fas ligand is a well-known inducer of apoptosis in cells expressing its receptor Fas; it also prevents autoimmunity by inducing apoptosis of activated T cells. However, Fas ligand also mediates non-apoptotic functions involving inflammatory cell migration and cytokine responses. We sought here to study the role of Fas ligand in nephrotoxic nephriti...
Allograft rejection caused by antibodies in sensitised individuals remains a real problem in human allotransplantation. There would be value in a simple model of this process to evaluate the mechanisms involved in antibody-mediated damage and the development of accommodation, as well as the impact of potential interventions. We have thus developed...
The narrow therapeutic window of cyclosporine A (CsA) means its use is controlled by pharmacokinetic monitoring. However, pharmacokinetics do not always reflect the functional effects of a drug--its pharmacodynamics, such as vasoconstriction. We developed a technique for measuring renal blood flow and used a pig model to determine whether CsA-induc...
Apoptosis is a source of much research interest across many fields, including developmental biology, immunology and oncology. As the exact pathways of this process are identified, so too are potential avenues for therapeutic application. Death receptors are important in inducing apoptosis and together with their ligands have become a source of atte...
The pig is generally regarded as likely to be the preferred donor animal in xenotransplantation. Although many hurdles remain to be cleared, it would be useful to be able to manipulate porcine endothelium genetically, among other reasons, to test approaches in the modulation of inflammation. However, as a nondividing cell, it is less easy to manipu...
Transplantation remains one of the most discussed surgical specialties within the media, from both a scientific and ethical point of view. In a lifetime transplantation has moved from a speculative experiment to a relatively commonplace lifesaving set of procedures. Within medicine, transplantation offers interaction between some of the sickest pat...
Citations
... This results in proliferative glomerulonephritis with macrophage infiltration and glomerular capillary thrombosis with renal impairment and albuminuria. Mice defective in FasL are protected from nephrotoxic nephritis [11]. There are a number of potential contributors to the protection of FasL defective mice from NTN, including reduced generation of proinflammatory cytokines, effects on cell death (including apoptosis or necroptosis) and effects on the immune response. ...
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... Pigs are the large mammalian species of choice for preclinical testing of vascular surgical procedures and vasculartargeted therapies [1][2][3]. Porcine models of clinical disease are well established, including ischaemic stroke [4] and carotid atherosclerosis [5]. Pigs have significant advantages over small animal models, in terms of cardiovascular physiology, vessel dimensions and immunology [6][7][8][9]. ...
... Among the DRs, DR4 and DR5 are the functional cell surface receptors that mediate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. The merits of targeting the TRAIL pathway for cancer therapy have been thoroughly discussed in the literature, as it selectively induces apoptosis in cancer cells, sparing normal cells [10][11][12][13][14][15]. ...
... Pigs are the large mammalian species of choice for preclinical testing of vascular surgical procedures and vasculartargeted therapies [1][2][3]. Porcine models of clinical disease are well established, including ischaemic stroke [4] and carotid atherosclerosis [5]. Pigs have significant advantages over small animal models, in terms of cardiovascular physiology, vessel dimensions and immunology [6][7][8][9]. ...
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