Partomuan Simanjuntak's research while affiliated with Indonesian Institute of Sciences and other places

Publications (78)

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Lemongrass is a wealth of Indonesian spices that have many functional benefits. The purpose of the study was to extract lemongrass essential oil and determine the difference of the type of material, extraction method, and plant parts on the phytochemical characteristics of the extract produced. Lemongrass is extracted in fresh and dried form. The s...
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Salam (Syzygium polyanthum), stevia (Stevia rebaudiana), tea (Camellia sinensis), and yakon (Smallanthus sonchifolius) leaves act as inhibitors of the α-glucosidase enzyme. The aims of this research were to (i) determine the best combination of polyherbals that could inhibit the α-glucosidase enzyme, (ii) determine the phytochemical content of the...
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Dendrophthoe pentandra (L.) Mig) is a parasitic plant that grows on cacao trees (Theobroma cacao L). Methanol extract of D. pentandra (L.) Mig) leaves had an IC50 value of 30.31 µg/mL as antioxidant activity and the results of phytochemical screening were contained flavonoid compounds. The aim of this research is to isolate and identification of a...
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Diabetes mellitus is a degenerative disease in the form of metabolic disorders characterized by increased blood glucose levels and impaired insulin metabolism. Yakon leaves and tea leaves contain phenolic compounds which have ?-glucosidase inhibiting activity. The aims of this study was to determine the inhibitory activity of the ?-glucosidase enzy...
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Yacon (Smallanthus sonchifolius (Poepp.) H. Robinson) leaves is traditionally consumed as herbal tea in many countries including Indonesia. This plant’s antidiabetic properties have been extensively researched, but studies on the responsible active compound identification are scarce. Information on the active compounds is critical for the consisten...
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Traditionally and scientifically, research has shown that Orthosiphon aristatus and Oryza sativa L. var. glutinosa have antidiabetic activity. The combination of two medicinal plants can increase their biological activity. This study aimed to determine the antidiabetic activity of O. aristatus and O. sativa L. var. glutinosa on single and combined...
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em> Avocado ( Persea americana Mill.) is a plant widely found in tropical regions such as Indonesia. Currently, people only consume the avocado flesh and dispose of the seed. This study aimed to examine the antioxidant activity, isolate and identify the active antioxidant structure from avocado seed extracts. The trial was conducted from January to...
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Caulerpa lentillifera is one of the most potential green seaweed to explored. It is abundantly available and cultivated in several region in Indonesia. Seaweed is well-known as a low lipid content but it is arranged by polyunsaturated fatty acid. Generally, organic solvent is used for lipid extraction. In an extraction method needs pre-treatment su...
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Isolation and identification one of chemical compound mono-terpene from Keji beling plant (local name) (Strobilanthes crispa) has been done. Extraction was carried out by maceration of the keji beling leaf powder with ethanol 96%, then partitioned with water-ethyl acetate. Ethylacetate extract was isolated and purified by a cytotoxic guide fraction...
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Penyakit Alzheimer (Alzheimer Disease, AD) adalah suatu penyakit dimana terjadinya kerusakan otak yang ditandai dengan penurunan dari perhatian, memori, dan kepribadian. AD merupakan salah satu akibat dari ganguan fungsi asetilkolin. Dalam hal ini, Asetilkolinesterase (AChE) merupakan enzim yang berfungsi sebagai katalisator pada pemecahan asetilko...
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An isolation and identification of phenolic compounds from Halban Leaves (Vitex pinnata Linn), a traditional medicinal plant in Aceh, has been done. Halban leaves were extracted through methanol maceration followed by isolation. The methanol extract went into n-hexane and ethyl acetate partition consecutively resulting in 3 different fractions of e...
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Diabetes mellitus is still a serious health problem both in the world and in Indonesia. The use of plants as a source of antidiabetic medicine is still needed. Bintangur plant, Calophyllum rigidum, contains active compounds that have the potential to act as anti-diabetic drugs but have not been used optimally. The purpose of this study was to deter...
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Cinnamon (Cinnamomum spp) is one of important export commodity for Indonesia. With annual production capacity about 103.594 tons, Indonesia is one of main cinnamon’s exporter especially to United States. Recently the utilization of cinnamon is developed, where not only use as spices but also use in pharmaceutical and cosmetic industries. The develo...
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Antioxidants are compounds needed by the body to fight free radicals that can cause adverse effects on health. All parts of turmeric plant have antioxidant activity, so does the flower. It is thought that the endophytic fungi from turmeric flowers also have antioxidant activity and no studies have reported it yet. The purpose of this study was to s...
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Nutmeg plant (Myristica fragrans Houtt) is known as one of traditional medicine. The nutmeg root has a strong potential in antioxidant and anticancer agents among other nutmeg plant parts. The n-hexane root extract has been carried out by thin-layer chromatography and obtained 8 fractions (labeled as Myristica fragrans Houtt Root: MFHR 1 − 8). Spec...
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Smallanthus sonchifolius [Poepp. & Endl.] H. Robinson (Asteraceae) also known as Yacon or insulin plant, is traditionally used for treating diabetes. Varying geographical origins and postharvest handling, however, seem to affect quantitative and qualitative metabolites in the leaves of Smallanthus sonchifolius [Poepp. & Endl.] H. Robinson (Yacon)....
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em> Indonesian medicinal plants, such as Strobilanthes crispa (L.) Blume (locally known as kecibeling), red mangrove ( Rhizophora stylosa Griff.) and star gooseberry { Sauropus androgynus (L.) Merr.} contain active compounds that act as antioxidants. The study aimed to determine the effect of extraction methods (maceration and infusion) on the anti...
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p> Yakon merupakan tanaman yang dapat digunakan untuk pengobatan dan kebutuhan pangan. Salah satu kandungan zat berkhasiat dalam daun yakon adalah asam klorogenat. Asam klorogenat diketahui memiliki aktifitas sebagai antioksidan, antikanker dan antidiabetes. Penentuan kadar asam klorogenat dalam matriks yang kompleks diperlukan metode yang selektif...
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p> Yakon merupakan tanaman yang dapat digunakan untuk pengobatan dan kebutuhan pangan. Salah satu kandungan zat berkhasiat dalam daun yakon adalah asam klorogenat. Asam klorogenat diketahui memiliki aktifitas sebagai antioksidan, antikanker dan antidiabetes. Penentuan kadar asam klorogenat dalam matriks yang kompleks diperlukan metode yang selektif...
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Mangroves have proven to possess strong bioactivities to survive their complex environmental condition. However, apart from the primary function of mangroves as an ecosystem keeper, mangroves are often overexploited for construction materials. Hence, their medicinal purposes are often overlooked, and the direct exploration of pharmacologically acti...
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Mangrove derived endophytic fungi are particular interest because they constitute the second-largest environmental group of marine fungi and are adapted to extreme conditions, which make them a rich source for novel metabolite and enzyme discovery. Especially the bioactivities of endophytic fungi from mangrove’s fruits have not been explored yet. W...
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Air pollution can increase free radicals that may worsen some diseases. Antioxidants such as phenol and flavonoid compounds are known to counteract these free radicals. Long term use of synthetic antioxidants is known to cause bad effects on the body. Therefore, the necessity to search for natural antioxidants from plants and its endophytic microbe...
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Diabetes mellitus is one of the metabolic disorders that causes an increase in blood sugar levels above normal the normal threshold. The case of diabetes is usually accompanied by an increase in free radicals in the patient’s body. In Indonesia, one of the plants traditionally used to treat high blood sugar levels and contains antioxidant compounds...
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Polyunsaturated fatty acids (PUFA) are essential nutrients that play an essential role in the functioning of the brain and cell growth. Mammals, including human, cannot synthesize PUFA. Therefore, the intake of PUFA must be obtained from dietary sources. Marine macroalgae, such as Caulerpa lentilifera , are excellent sources for high PUFA. The extr...
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Postprandial hyperglycemia is triggered by two enteric proteins (α-amylase and α-glucosidase) connected to the brush border of intestinal cells. In diabetic populations, Type 2 Diabetes Mellitus is more prevalent, and α-glucosidase inhibition is the suitable therapy for delaying glucose intake after meals. This study was designed to investigate che...
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An increase in blood glucose levels in people with diabetes can cause an increase in free radicals, which can worsen the disease. Thus, drugs that have antidiabetic and antioxidant activities are needed. The cinnamon plant is high in antioxidants and has long been used as a source for a diabetes drug. The utilization of endophytic fungi isolated fr...
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Duku’s mistletoe leaves (Dendrophtoe pentandra (L.) Miq) is a parasitic plant part with botanical insecticides quality. Preliminary test was done using phenolic extract test with FeCl 3 to know the content of the leaves’s phenolic compound and its toxicity effect. The effects of the toxicity were observed with Brine Shrimp Lethality Test (BSLT) met...
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Penelitian ini melakukan kajian terhadap toksisitas ekstrak etil asetat dari kuli biji jengkol (Archidendron jiringa) Jack. I. C. Nielsen) dengan menggunakan metode Brine Shrimp Lethality Test (BSLT). Nilai LC50 ekstrak diperoleh dari persamaan regresi linear dari log konsentrasi vs probit % mortalitas. Kulit biji jengkol dikeringkan pada temperatu...
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Uji aktivitas antioksidan yang dilakukan terhadap ekstrak methanol dari daun benalu duku hijau (Dendrophthoe pentandara (L.) Miq) dan daun benalu duku merah (Scurrula ferruginea (Jack) Danser) dengan menggunakan metode DPPH bertujuan untuk membandingkan aktivitas antioksidan antara kedua daun benalu duku yang berbeda warna tersebut. Daun benalu duk...
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The utilization of mangrove plants as traditional medicinal ingredients has long been utilized by the community for treatment of various diseases in favour of bioactive components from its secondary metabolites. Secondary metabolites from mangroves could act as an antioxidant to prevent oxidative stress. Mangrove may contain endophytic microbes in...
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The leaves of yacon (Smallanthussonchi folius [Poepp. &Endl.] H. Robinson) or in Indonesia known as “Daun insulin” (Insulin leaf), scientifically has various medicinal properties and one of them as antidiabetic. The aim of this research is to know α-glucosidase enzyme inhibitor compound in the ethanol 96% extract of yacon leaves. Fractionation of e...
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Uji fenolik ekstrak dilakukan dengan menggunakan FeCl 3 untuk mengetahui kandungan senyawa fenolik dari daun benalu duku hijau (Dendrophthoe pentandara (L.) Miq) dan daun benalu duku merah (Scurrula ferruginea (Jack) Danser) serta efek toksisitas telah diamati dengan metode Brine Shrimp Lethality Test (BSLT). Daun benalu duku diekstrak hingga diper...
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Propinsi Aceh khususnya Kota Langsa memiliki banyak tanaman yang dapat berkhasiat sebagai obat, diantaranya adalah tanaman halban (Vitex pinnata Linn). Tujuan dari penelitian ini adalah mengetahui aktivitas antioksidan dari empat jenis fraksi yaitu fraksi metanol, etil asetat, air dan fraksi n- heksan dari daun halban (Vitex pinnata Linn) asal Aceh...
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Penelitian ini dilakukan untuk menentukan aktivitas antioksidan fenolik total dari ekstrak kulit biji jengkol. Kulit biji jengkol dalam bentuk serbuk yang sudah dikering angin anginkan selama 1x24 jam dimaserasi dengan metanol selama 1x24 jam. Ekstrak yang diperoleh dilarutkan dengan air secara berulang-ulang dan kemudian fraksi air dipartisi denga...
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Malaria is still the leading cause of death worldwide with nearly half the world's population at risk. Parasitic resistance to existing antimalarial drugs in the market makes the search for a source of new drugs from nature is very important. Therefore, the aims of this study are to determine in vitro antimalarial activity of endophytic fungi extra...
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Antioxidant Activity of Endophytic Fungi Cb.Gm.B3 Extract from Cinnamon (Cinnamomum burmanni) TwigsABSTRACTThere are many degenerative diseases that are caused by a free radical effect. Cinnamon (Cinnamomum burmanni) contains cinnamaldehyde compounds that have activity as a powerful antioxidant and fight free radicals. Endophytic fungi can be found...
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Pemanfaatan kulit biji jengkol masih sangat terbatas, bahkan sering ditemukan menjadi tumpukan sampah organik di pasar-pasar tradisional daerah Sumatera Utara. Penelitian ini bertujuan untuk menyelidiki kandungan senyawa fenolik yang terdapat pada kulit biji jengkol. Senyawa fenolik memiliki aktivitas antioksidan yang dapat mencegah beberapa jenis...
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Objective: The objective of this research is to evaluate the antioxidant and antibacterial activity of methanol, n-hexane, ethyl acetate, and flavonoid total of Dendrophthoe pentandra (L.) Miq extract.Methods: The leaf of D. pentandra (L.) Miq was gradually extracted using methanol, n-hexane, and ethyl acetate. From that extraction process, various...
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Antidiabetic and cytotoxic activity examination of ethyl acetate extract of betel leaf (Piper betle L.) has been done. The antidiabetic activity test was performed in vitro by investigating the inhibition of the extract against the activity of a-glucosidase enzyme. The IC50, of the ethyl acetate extract of betel leaves against the a-glucosidase wer...
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Objective: This study was aimed to isolate and investigate antioxidant activity of gallic acid in pods of jiringa (Archidendron jiringa [Jack] I.C. Nielsen).Methods: Pods of jiringa were extracted by maceration. Phenolic compounds were tested using FeCl3. Identification of pure compound was obtained from spectra data from nuclear magnetic resonance...
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Objective: This research was study about phytochemical active phenolic compound from pods of jiringa (Archidendron jiringa (Jack) I. C. Nielsen) and it’s antioxidant.Methods: Pods of jiringa were air dried and macerated with methanol. Extract was evaporated using rotary evaporator, and then, crude extract dissolved with water and partitioned with e...
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An iridoid compound with antioxidant activity was isolated from the water extract of leaves of Halban (Vitex pinnata Linn.). Isolation and identification processes of the compound were performed based on the bioassay-activity-guided method using the free radical scavenging method for antioxidant. The purification was done by the column chromatograp...
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Objective: This research was study about phytochemical active phenolic compound from pods of jiringa (Archidendron jiringa (Jack) I. C. Nielsen) and it’s antioxidant.Methods: Pods of jiringa were air dried and macerated with methanol. Extract was evaporated using rotary evaporator, and then, crude extract dissolved with water and partitioned with e...
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Senyawa golongan fenolik adalah senyawa aktif dari tanaman sirih yang berpotensi digunakan sebagai bahan obat alami. Penelitian ini bertujuan untuk menguji aktivitas sitotoksik senyawa golongan fenolik dari daun sirih (Piper betle L.). Aktivitas sitotoksik diuji dengan mengukur nilai LC50 menggunakan metode Brine Shrimp Lethality Test (BSLT). Ekstr...
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This study was started by extraction of Eucalyptus deglupta Blume. Using organic solvent (n-hexane, ethyl acetate, ethanol and water) followed by phytochemical screening and toxicity test using Brine Shrimp Lethality Test (BSLT) method. Isolation and identification of chemical compounds contained in the fraction were done by column chromatography a...
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Abstrak Alzheimer Disease (AD) adalah jenis penyakit yang umum dari dimensia yang menggambarkan kondisi ketika sel-sel saraf (neuron) di otak mati dan tidak lagi berfungsi normal. Kematian dan kerusakan neuron menyebabkan perubahan memori, perilaku dan kemampuan berpikir jernih.Penhambatan asetilkolinesetrase (AChE) dapat dinaikkan jumlah neurotran...
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Turmeric (Curcuma longa L.) is a medicinal plant that is commonly used as spice and preservative. Many types of endophytic fungi have been reported as being associated with medicinal plants and able to synthesize secondary metabolites. In this study, endophytic fungi were isolated from all plant parts of turmeric plants, including the root, rhizome...
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Malaria infection is still a public health problem, especially in developing countries, including Indonesia. Malaria infection is usually accompanied by increased free radicals in the body of the patient. This situation will cause decreasing the immune system of the patient. Explorating of new drugs that have antimalarial and also antioxidant activ...
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Ranti hitam plant (Solanum blumei Nees ex Blume), Solanaceae family is found in Karo and Dairi, traditionally used as a medicinal plant. The results of phytochemical analysis of extract of S. blumei Nees ex Blume shows that secondary metabolites alkaloids, flavonoids, tannins and saponin are more numerous in the ethanol extract of the leaves than t...
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Tanaman ranti hitam (Solanum blumei Nees ex Blumei), famili Solanaceae, ditemukan di daerah Dairi dan Karo, secara tradisional digunakan sebagai tanaman obat. Pengujian aktivitas antikanker dari ekstrak etanol buah ranti hitam terhadap sel leukemia L1210 telah dilakukan dengan metode hemositometri setelah diinkubasi 48 jam pada suhu 37°C di dalam i...
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Objective: Colletotrichium capsici endophytic fungi isolated from Jamblang plant (Eugenia cumini L). The secondary metabolites of this plant has the potent antibacterial efficacy as well as diarrheal and anti-diabetic. This research focussed on isolation of the endophytic microbes from branches of Jamblang plants and their secondary metabolites.Met...
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Kunyit or turmeric plant (Curcuma longa L.) is a native Southeast Asia plant that has been widely used as herbal medicine. In our previous research we isolated and screened 44 of endophytic fungi of turmeric plant from Sukabumi and Cibinong to determine their antioxidant activity. There were 4 samples isolated from Sukabumi with antioxidant activit...
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Two flavonoids were isolated from leaves of Benalu Jeruk (Scurrula fusca G. Don) by extracting the leaves powder with methanol. The methanol extract was partitioned with ethyl acetate. The ethyl acetate extract was then partitioned further with mixture of methanol and nhexane. The methanolic layer was separated and hydrolyzed with 2 N HCl to give f...
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A flavonoid compound i.e. 3,5,7,4′-tetrahydroxy-dihydroflavonol or dihydrocaempferol which has contents an antioxidant activity with IC50 value about 9.75 ppm were successfully isolated and identified. The structures of the obtained compound are identified using spectral data analysis such as ultra-violet, infrared, 1D NMR (1H NMR, 13C NMR), 2D NMR...